Integrative modeling of transcriptional regulation in response to antirheumatic therapy (2009)
Hecker, Michael, Goertsches, Robert, Engelmann, Robby, Thiesen, Hans-Juergen, Guthke, Reinhard
Abstract Background The investigation of gene regulatory networks is an important issue in molecular systems biology and significant progress has been made by combining different types of biological...
Adapted Boolean network models for extracellular matrix formation (2009)
Wollbold, Johannes, Huber, René, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, Kinne, Raimund W, ...
Abstract Background Due to the rapid data accumulation on pathogenesis and progression of chronic inflammation, there is an increasing demand for approaches to analyse the underlying regulatory...
Huber, René, Hummert, Christian, Gausmann, Ulrike, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, ...
Abstract Introduction Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating...
Constructing a Knowledge Base for Gene Regulatory Dynamics by Formal Concept Analysis Methods (2008)
Wollbold, Johannes, Guthke, Reinhard, Ganter, Bernhard
Our aim is to build a set of rules, such that reasoning over temporal dependencies within gene regulatory networks is possible. The underlying transitions may be obtained by discretizing observed...
Koczan, Dirk, Drynda, Susanne, Hecker, Michael, Drynda, Andreas, Guthke, Reinhard, Kekow, Joern, ...
Abstract Introduction About 30% of rheumatoid arthritis patients fail to respond adequately to TNFα-blocking therapy. There is a medical and socioeconomic need to identify molecular markers for an...
BIOINFORMATICS Convergence of the Proteomic Pattern in Cancer (2008)
Ute Müller, Günther Ernst, Christian Melle, Reinhard Guthke
Motivation: On the histological level the differentiation of normal epithelial tissues is well known and also the phenomenon of dedifferentiation which occurs the more the cells develop towards...
Pfaff, Michael, Woetzel, Dirk, Driesch, Dominik, Toepfer, Susanne, Huber, René, Pohlers, Dirk, ...
Zum Vol. I von: Computer science meets automation: 52. IWK, Internationales Wissenschaftliches Kolloquium ; proceedings ; 10 - 13 September 2007 Zum Vol. II von: Computer science meets automation:...
A 2-compartment model of glutamine and ammonia metabolism in liver tissue (2007)
Toepfer, Susanne, Zellmer, Sebastian, Driesch, Dominik, Woetzel, Dirk, Guthke, Reinhard, Gebhardt, Rolf, ...
Zum Vol. I von: Computer science meets automation: 52. IWK, Internationales Wissenschaftliches Kolloquium ; proceedings ; 10 - 13 September 2007 Zum Vol. II von: Computer science meets automation:...
Albrecht, Daniela, Kniemeyer, Olaf, Brakhage, Axel A., Berth, Matthias, Guthke, Reinhard
A data warehouse for the integrated storage and visualisation of genome and experimental transcriptome and proteome data of human-pathogenic fungi was established. It provides tools for uploading...
Dürrschmid, Karin, Schmidt-Heck, Wolfgang, Hrebicek, Thomas, Reischer, Helga, Auer, Norbert, Margreiter, Gerd, ...
No abstract available.
BIOINFORMATICS DISCOVERY NOTE Systems biology (2006)
Ute Müller, Günther Ernst, Christian Melle, Reinhard Guthke, Von Eggeling
Convergence of the proteomic pattern in cancer
Convergence of the proteomic pattern in cancer (2006)
Müller, Ute, Ernst, Günther, Melle, Christian, Guthke, Reinhard, Von Eggeling, Ferdinand
Motivation: On the histological level the differentiation of normal epithelial tissues is well known. The phenomenon of dedifferentiation, which occurs as cells develop towards malignancy is also...
Guthke, Reinhard, Möller, Ulrich, Hoffmann, Martin, Thies, Frank, Töpfer, Susanne
Motivation: The immune response to bacterial infection represents a complex network of dynamic gene and protein interactions. We present an optimized reverse engineering strategy aimed at a...
Reinhard Guthke, Ulrich Möller, Martin Hoffmann, Frank Thies, Susanne Töpfer
* To whom correspondence should be addressed.
Guthke, Reinhard, Möller, Ulrich, Hoffmann, Martin, Thies, Frank, Töpfer, Susanne
Motivation: The immune response to bacterial infection represents a complex network of dynamic gene and protein interactions. We present an optimized reverse engineering strategy aimed at a...
Guthke, Reinhard, Möller, Ulrich, Hoffmann, Martin, Thies, Frank, Töpfer, Susanne
Motivation: The immune response to bacterial infection represents a complex network of dynamic gene and protein interactions. We present an optimized reverse engineering strategy aimed at a...
Gene expression data mining for functional genomics (2000)
Reinhard Guthke, Wolfgang Schmidt-heck, Daniel Hahn, Michael Pfaff
escherichia coli Abstract: Methods for supervised and unsupervised clustering and machine learning were studied in order to automatically model relationships between gene expression data and gene...
A genetic-algorithm-based approach to optimization of bioprocesses described by fuzzy rules. (1997)
Angelov, Plamen, Guthke, Reinhard
A new approach to optimization of bioprocesses described by fuzzy rules is introduced in the paper. It is based on genetic algorithms (GA) and allows to determine optimal values or profiles of...
Dürrschmid, Karin, Schmidt-Heck, Wolfgang, Hrebicek, Thomas, Reischer, Helga, Auer, Norbert, Margreiter, Gerd, ...
Koczan, Dirk, Drynda, Susanne, Hecker, Michael, Drynda, Andreas, Guthke, Reinhard, Kekow, Joern, ...
Huber, René, Hummert, Christian, Gausmann, Ulrike, Pohlers, Dirk, Koczan, Dirk, Guthke, Reinhard, ...