Roland Krüger, Reinhart Heinrich
We present a framework for model reduction of signal transduction networks. The methods are explained by considering a recent model for Wnt/β-catenin signalling which plays an important regulatory...
A theory of optimal differential gene expression (2004)
Liebermeister,Wolfram, Klipp,Edda, Schuster,Stefan, Heinrich,Reinhart
We investigate a model of optimal regulation, intended to describe large-scale differential gene expression. Relations between the optimal expression patterns and the function of genes are deduced...
A theory of optimal differential gene expression (2004)
Liebermeister, Wolfram, Klipp, Edda, Schuster, Stefan, Heinrich, Reinhart
We investigate a model of optimal regulation, intended to describe large-scale differential gene expression. Relations between the optimal expression patterns and the function of genes are deduced...
Jorrit J. Hornberg, Frank J. Bruggeman, Bernd Binder, Christian R. Geest, Jan Lankelma, Reinhart Heinrich, ...
Principles behind the multifarious control of signal transduction
Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling is important in both oncogenesis and development. Mathematical modeling predicts several unusual features of the Wnt pathway, some of which are tested experimentally.
Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Ethan Lee, Adrian Salic, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator b-catenin. Recent studies have...
Klipp,Edda, Heinrich,Reinhart, Holzhütter,Hermann-Georg
A computational approach is used to analyse temporal gene expression in the context of metabolic regulation. It is based on the assumption that cells developed optimal adaptation strategies to...
Klipp, Edda, Heinrich, Reinhart, Holzhütter, Hermann-Georg
A computational approach is used to analyse temporal gene expression in the context of metabolic regulation. It is based on the assumption that cells developed optimal adaptation strategies to...
Mathematical models of protein kinase signal transduction (2002)
Reinhart Heinrich, Benjamin G. Neel, Tom A. Rapoport
distinct ways to elicit either a sustained or a transient response, which can have dramatically different consequences (Marshall, 1995)? These and other questions Department of Biophysics can be...
Christophe H. Schilling, Stefan Schuster, Bernhard O. Palsson, Reinhart Heinrich
This article reviews the relatively short history of metabolic pathway analysis. Computer-aided algorithms for the synthesis of metabolic pathways are discussed. Important algebraic concepts used in...
Kernstrukturen und Peierlspotentiale von Versetzungen in kubisch-raumzentrierten Gittern. (1971)
Heinrich, Reinhart., Schellenberger, Wolfgang.
Dresden, T. U., F. f. Naturwiss. u. Math., Diss., 1971 (Nicht f. d. Austausch).
GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model
Höfer, Thomas, Nathansen, Holger, Löhning, Max, Radbruch, Andreas, Heinrich, Reinhart
Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2, can be induced by antigen and polarizing...
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model
Höfer, Thomas, Nathansen, Holger, Löhning, Max, Radbruch, Andreas, Heinrich, Reinhart
Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2, can be induced by antigen and polarizing...
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Generation of nonidentical compartments in vesicular transport systems
Heinrich, Reinhart, Rapoport, Tom A.
How can organelles communicate by bidirectional vesicle transport and yet maintain different protein compositions? We show by mathematical modeling that a minimal system, in which the basic variables...
Protein phosphatase 1 regulates assembly and function of the β-catenin degradation complex
Luo, Wen, Peterson, Annita, Garcia, Benjamin A, Coombs, Gary, Kofahl, Bente, Heinrich, Reinhart, ...
The Wnt/β-catenin signaling pathway is critical in both cellular proliferation and organismal development. However, how the β-catenin degradation complex is inhibited upon Wnt activation remains...