Scientific Commons: Reinhold Welker

Bedeutung des Nef Proteins für die Infektiosität des Humanen Immundefizienzvirus (HIV) / (1997)

Heidelberg, Univ., Diss., 1997 (Nicht für den Austausch).

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

Schubert, Ulrich, Ott, David E., Chertova, Elena N., Welker, Reinhold, Tessmer, Uwe, Princiotta, Michael F., ...

Retrovirus assembly and maturation involve folding and transport of viral proteins to the virus assembly site followed by subsequent proteolytic cleavage of the Gag polyprotein within the nascent...

Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity

Welker, Reinhold, Harris, Mark, Cardel, Bettina, Kräusslich, Hans-Georg

The nef gene of primate immunodeficiency viruses is essential for high-titer virus replication and AIDS pathogenesis in vivo. In tissue culture, Nef is not required for human immunodeficiency virus...

Biochemical and Structural Analysis of Isolated Mature Cores of Human Immunodeficiency Virus Type 1

Welker, Reinhold, Hohenberg, Heinrich, Tessmer, Uwe, Huckhagel, Carola, Kräusslich, Hans-Georg

Mature human immunodeficiency virus type 1 (HIV-1) particles contain a cone-shaped core structure consisting of the internal ribonucleoprotein complex encased in a proteinaceous shell derived from...

Organization of Immature Human Immunodeficiency Virus Type 1

Wilk, Thomas, Gross, Ingolf, Gowen, Brent E., Rutten, Twan, De Haas, Felix, Welker, Reinhold, ...

Immature retrovirus particles contain radially arranged Gag polyproteins in which the N termini lie at the membrane and the C termini extend toward the particle's center. We related image features to...

A New RNA Element Located in the Coding Region of a Murine Endogenous Retrovirus Can Functionally Replace the Rev/Rev-Responsive Element System in Human Immunodeficiency Virus Type 1 Gag Expression

Wodrich, Harald, Bohne, Jens, Gumz, Ellen, Welker, Reinhold, Kräusslich, Hans-Georg

Nuclear export of incompletely spliced RNAs is a prerequisite for retroviral replication. Complex retroviruses like human immunodeficiency virus (HIV) encode a viral transport factor (Rev), which...

Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

Hildinger, Markus, Dittmar, Matthias T., Schult-Dietrich, Patricia, Fehse, Boris, Schnierle, Barbara S., Thaler, Sonja, ...

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of...

Structural organization of authentic, mature HIV-1 virions and cores

Briggs, John A.G., Wilk, Thomas, Welker, Reinhold, Kräusslich, Hans-Georg, Fuller, Stephen D.

Mature, infectious HIV-1 particles contain a characteristic cone-shaped core that encases the viral RNA and replication proteins. The architectures of mature virions and isolated cores were studied...