Burnett, James C., Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G., Ruthel, Gordon, Hermone, Ann R., ...
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including...
Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...
Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...
Novel Small Molecule Inhibitors of Botulinum Neurotoxin a Metalloprotease Activity (2003)
Burnett, James C., Schmidt, James J., Stafford, Robert G., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., ...
Botulinum neurotoxins (BoNTs) are among the most lethal biological substances to have been weaponized and are listed as biodefense category A agents. Currently, no small molecule (non-peptidic)...
Molecular Mechanisms of Filovirus Cellular Trafficking (1998)
Aman, M. J., Bosio, Catharine M., Panchal, Rekha G., Burnett, James C., Schmaljohn, Alan
The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with the phylogenetically or...
Panchal, Rekha G., Halverson, Kelly M., Ribot, Wilson, Lane, Douglas, Kenny, Tara
Anthrax protective antigen (PA, 83 kDa), a pore-forming protein upon protease activation to 63 kDa (PA63), translocates lethal factor (LF) and edema factor (EF) from endosomes into the cytosol of the...
Dendritic Cells Endocytose Bacillus Anthracis Spores: Implications for Anthrax Pathogenesis (1998)
Brittingham, Katherine C., Ruthel, Gordon, Panchal, Rekha G., Fuller, Claudette L., Ribot, Wilson J.
Phagocytosis of inhaled Bacillus anthracis spores and subsequent trafficking to lymph nodes are decisive events in the progression of inhaled anthrax because they initiate germination and...
Analysis of Ebola Virus and VLP Release Using an Immunocapture Assay (1998)
Kallstrom, George, Warfield, Kelly L., Swenson, Dana L., Mort, Shannon, Panchal, Rekha G., Ruthel, Gordon, ...
Ebola virus (EBOV), an emerging pathogen, is the causative agent of a rapidly progressive hemorrhagic fever with high mortality rates. There are currently no approved vaccines or treatments available...
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...
Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...
Nguyen, Tam L., Schoehn, Guy, Weissenhorn, Winfried, Hermone, Ann R., Burnett, James C., Panchal, Rekha G., ...
The matrix protein VP40 is an indispensable component of viral assembly and budding by the Ebola virus. VP40 is a monomer in solution, but can fold into hexameric and octameric states, two oligomeric...
Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade (1998)
Halverson, Kelly M., Panchal, Rekha G., Nguyen, Tam L., Gussio, Rick, Little, Stephen F., Misakian, Martin, ...
Bacillus anthracis secretes three proteins (protective antigen, PA; lethal factor, LF; and edema factor, EF) that are the basis for anthrax infection. We present electrophysiological measurements...
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Panchal, Rekha G., Ruthel, Gordon, Kenny, Tara A., Kallstrom, George H., Lane, Douglas, Badie, Shirin S., ...
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified protein...
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Panchal, Rekha G., Ruthel, Gordon, Kenny, Tara A., Kallstrom, George H., Lane, Douglas, Badie, Shirin S., ...
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified protein...
Ribot, Wilson J., Panchal, Rekha G., Brittingham, Katherine C., Ruthel, Gordon, Kenny, Tara A., Lane, Douglas, ...
Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and...
Sizing the Bacillus anthracis PA63 Channel with Nonelectrolyte Poly(Ethylene Glycols)
Nablo, Brian J., Halverson, Kelly M., Robertson, Joseph W. F., Nguyen, Tam L., Panchal, Rekha G., Gussio, Rick, ...
Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA63). Based on the ability of...
Shanks, John, Burtnick, Mary N., Brett, Paul J., Waag, David M., Spurgers, Kevin B., Ribot, Wilson J., ...
Burkholderia mallei, a category B biothreat agent, is a facultative intracellular pathogen that causes the zoonotic disease glanders. The B. mallei VirAG two-component regulatory system activates the...