Renée X. de Menezes

Can subtle changes in gene expression be consistently detected with different microarray platforms? (2008)

Pedotti, Paola, 't Hoen, Peter AC, Vreugdenhil, Erno, Schenk, Geert J, Vossen, Rolf HAM, Ariyurek, Yavuz, ...

Abstract Background The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the...

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms (2008)

Ariyurek, Yavuz, Thygesen, Helene H., Vreugdenhil, Erno, De Menezes, Renée X., ...

The hippocampal expression profiles of wild-type mice and mice transgenic for δC-doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology and five different microarray...

Dissecting systems-wide data using mixture models: application to identify affected cellular processes (2005)

Svensson, J Peter, De Menezes, Renée X, Turesson, Ingela, Giphart-Gassler, Micheline, Vrieling, Harry

Abstract Background Functional analysis of data from genome-scale experiments, such as microarrays, requires an extensive selection of differentially expressed genes. Under many conditions, the...

Quantile smoothing of array CGH data (2005)

Eilers, Paul H. C., De Menezes, Renée X.

Motivation: Plots of array Comparative Genomic Hybridization (CGH) data often show special patterns: stretches of constant level (copy number) with sharp jumps between them. There can also be much...

Gene expression variation between mouse inbred strains (2004)

Turk, Rolf, 't Hoen, Peter AC, Sterrenburg, Ellen, De Menezes, Renée X, De Meijer, Emile J, Boer, Judith M, ...

Abstract Background In this study, we investigated the effect of genetic background on expression profiles. We analysed the transcriptome of mouse hindlimb muscle of five frequently used mouse inbred...

Quantile smoothing of array CGH data (2004)

Eilers, Paul H. C., De Menezes, Renée X.

Motivation: Plots of array Comparative Genomic Hybridization (CGH) data often show special patterns: stretches of constant level (copy number) with sharp jumps between them. There also can be much...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH (2004)

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs (2004)

Turk, Rolf, Boer, Judith M., Sterrenburg, Ellen, De Menezes, Renée X., ...

In two‐colour microarrays, the ratio of signal intensities of two co‐hybridized samples is used as a relative measure of gene expression. Ratio‐based analysis becomes complicated and...

Quantile smoothing of array CGH data (2004)

Eilers, Paul H. C., De Menezes, Renée X.

Motivation: Plots of array Comparative Genomic Hybridization (CGH) data often show special patterns: stretches of constant level (copy number) with sharp jumps between them. There also can be much...

Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs

Turk, Rolf, Boer, Judith M., Sterrenburg, Ellen, De Menezes, Renée X., ...

In two-colour microarrays, the ratio of signal intensities of two co-hybridized samples is used as a relative measure of gene expression. Ratio-based analysis becomes complicated and inefficient in...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs

Turk, Rolf, Boer, Judith M., Sterrenburg, Ellen, De Menezes, Renée X., ...

In two-colour microarrays, the ratio of signal intensities of two co-hybridized samples is used as a relative measure of gene expression. Ratio-based analysis becomes complicated and inefficient in...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia

Holleman, Amy, Den Boer, Monique L., De Menezes, Renée X., Cheok, Meyling H., Cheng, Cheng, Kazemier, Karin M., ...

Childhood acute lymphoblastic leukemia (ALL) consists of various subtypes that respond differently to cytotoxic drugs and therefore have a markedly different clinical outcome. We used microarrays to...

Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis

Gaspar, Claudia, Cardoso, Joana, Franken, Patrick, Molenaar, Lia, Morreau, Hans, Möslein, Gabriela, ...

Expression profiling is a well established tool for the genome-wide analysis of human cancers. However, the high sensitivity of this approach combined with the well known cellular and molecular...

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms

Ariyurek, Yavuz, Thygesen, Helene H., Vreugdenhil, Erno, De Menezes, Renée X., ...

The hippocampal expression profiles of wild-type mice and mice transgenic for δC-doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology and five different microarray...