Gerlach, Lars-Ole, Hatse, Sigrid, Skerlj, Renato T, Bridger, Gary J, ...
AMD3465 is a novel, nonpeptide CXCR4 antagonist and a potent inhibitor of HIV cell entry in that one of the four-nitrogen cyclam rings of the symmetrical, prototype bicyclam antagonist AMD3100 has...
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor (2005)
Rosenkilde, Mette M, Schwartz, Thue W, Hernandez-Abad, Pedro E, ...
The chemokine receptors CCR5 and CXCR4 function as coreceptors for human immunodeficiency virus (HIV) and are attractive targets for the development of anti-HIV drugs. The most potent CXCR4...
Bridger, Gary J, Skerlj, Renato T, ...
The chemokine receptor CXCR4 is the main coreceptor used by T-tropic X4 HIV-1 strains to infect its target T cells. It has been proven that the CXCR4 expression level in T cells is strongly...
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity (2002)
Berlin, Aaron, Skerlj, Renato T, Bridger, Gary J
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...
AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity
Lukacs, Nicholas W., Berlin, Aaron, Schols, Dominique, Skerlj, Renato T., Bridger, Gary J.
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...