Scientific Commons: Richard A. Bowen

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia (2009)

England, Kathleen, Am Ende, Christopher, Lu, Hao, Sullivan, Todd J., Marlenee, Nicole L., Bowen, Richard A., ...

Objectives The National Institute of Allergy and Infectious Disease classifies Francisella tularensis as a Category A priority pathogen. Despite the availability of drugs for treating tularaemia, the...

A single positively selected West Nile viral mutation confers increased virogenesis in American crows (2007)

Brault, Aaron C., Huang, Claire Y-H, Langevin, Stanley A., Kinney, Richard M., Bowen, Richard A., Ramey, Wanichaya N., ...

West Nile virus ( WNV), first recognized in North America in 1999, has been responsible for the largest arboviral epiornitic and epidemic of human encephalitis in recorded history. Despite the well-...

DNA VACCINATION OF THE AMERICAN CROW (CORVUS BRACHYRHYNCHOS) PROVIDES PARTIAL PROTECTION AGAINST LETHAL CHALLENGE WITH WEST NILE VIRUS (2007)

Michel L. Bunning, Patricia E. Fox, Richard A. Bowen, Nicholas Komar, Tully J. Speaker, ...

Experimental West Nile Virus Infection in Eastern Screech Owls (Megascops asio) (2006)

Nicole M. Nemeth, D. Caldwell Hahn, Daniel H. Gould, Richard A. Bowen

WEST NILE VIRUS SEROSURVEILLANCE IN IOWA WHITE-TAILED DEER (1 999-2003) (2005)

Santatella, Julian, McLean, Robert, Hall, Jeffrey S., Gill, James S., Bowen, Richard A., Hadow, Harlo H., ...

Sera from white-tailed deer (Odocoileus virginianus) were collected in Iowa during the winter months (1999-2003), 2 years before and after West Nile virus (WNV) was first reported in Iowa (2001), and...

Expression of Human MxA Protein in Mosquito Cells Interferes with LaCrosse Virus Replication

Miura, Tanya A., Carlson, Jonathan O., Beaty, Barry J., Bowen, Richard A., Olson, Ken E.

Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes....

Epitope-Blocking Enzyme-Linked Immunosorbent Assays for the Detection of Serum Antibodies to West Nile Virus in Multiple Avian Species

Blitvich, Bradley J., Marlenee, Nicole L., Hall, Roy A., Calisher, Charles H., Bowen, Richard A., Roehrig, John T., ...

We report the development of epitope-blocking enzyme-linked immunosorbent assays (ELISAs) for the rapid detection of serum antibodies to West Nile virus (WNV) in taxonomically diverse North American...

Epitope-Blocking Enzyme-Linked Immunosorbent Assays for Detection of West Nile Virus Antibodies in Domestic Mammals

Blitvich, Bradley J., Bowen, Richard A., Marlenee, Nicole L., Hall, Roy A., Bunning, Michel L., Beaty, Barry J.

We evaluated the ability of epitope-blocking enzyme-linked immunosorbent assays (ELISAs) to detect West Nile virus (WNV) antibodies in domestic mammals. Sera were collected from experimentally...

Differential Virulence of West Nile Strains for American Crows

Brault, Aaron C., Langevin, Stanley A., Bowen, Richard A., Panella, Nicholas A., Biggerstaff, Brad J., Miller, Barry R., ...

Crow deaths were observed after West Nile virus (WNV) was introduced into North America, and this phenomenon has subsequently been used to monitor the spread of the virus. To investigate potential...

Envelope Glycoprotein Mutations Mediate Equine Amplification and Virulence of Epizootic Venezuelan Equine Encephalitis Virus

Greene, Ivorlyne P., Paessler, Slobodan, Austgen, Laura, Anishchenko, Michael, Brault, Aaron C., Bowen, Richard A., ...

Epidemics of Venezuelan equine encephalitis (VEE) result from high-titer equine viremia of IAB and IC subtype viruses that mediate increased mosquito transmission and spillover to humans. Previous...

Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation

Anishchenko, Michael, Bowen, Richard A., Paessler, Slobodan, Austgen, Laura, Greene, Ivorlyne P., Weaver, Scott C.

RNA viruses are notorious for their genetic plasticity and propensity to exploit new host-range opportunities, which can lead to the emergence of human disease epidemics such as severe acute...