OBSERVATIONS ON MODE OF ACTION OF ENDOTOXIN IN CHICK EMBRYOS (2006)
The preu uonfirmed the previous observation of Smith and Thomas that the chick embryo becomes refractory to intravenously administered endotoxin during the period frum the 11th to the 15th day of...
Cholera Toxin B Subunit Activates Arachidonic Acid Metabolism
Peterson, Johnny W., Finkelstein, Richard A., Cantu, Juan, Gessell, Deborah L., Chopra, Ashok K.
Cholera toxin (CT) increases intestinal secretion of water and electrolytes and modulates the mucosal immune response by stimulating cellular synthesis of arachidonic acid (AA) metabolites (e.g.,...
Environmental Signals Controlling Production of Hemagglutinin/Protease in Vibrio cholerae
Benitez, Jorge A., Silva, Anisia J., Finkelstein, Richard A.
Vibrio cholerae hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor...
Kossaczka, Zuzana, Shiloach, Joseph, Johnson, Virginia, Taylor, David N., Finkelstein, Richard A., Robbins, John B., ...
Epidemiologic and experimental data provide evidence that a critical level of serum immunoglobulin G (IgG) antibodies to the surface polysaccharide of Vibrio cholerae O1 (lipopolysaccharide) and of...
Jouravleva, Elena A., McDonald, Gregory A., Marsh, Jane W., Taylor, Ronald K., Boesman-Finkelstein, Mary, Finkelstein, Richard A.
We previously isolated from a 1994 isolate of Vibrio cholerae O139 a filamentous lysogenic bacteriophage, choleraphage 493, which inhibits pre-O139 but not post-O139 El Tor biotype V. cholerae...
Payne, Shelley M., Finkelstein, Richard A.
Exceptional strains of gonococci that grow on Congo red agar were found to be penicillin-resistant non-penicillinase producers.
Colonial Recognition, a “New” Approach for Rapid Diagnostic Enteric Bacteriology
Finkelstein, Richard A., Punyashthiti, Kannikar
The morphology, on MacConkey's agar, of colonies of the bacteria commonly found in enteric specimens is sufficiently characteristic and distinctive, when observed with transmitted oblique...
Ion transport during cholera-induced ileal secretion in the dog
Moore, William L., Bieberdorf, Fred A., Morawski, Stephen G., Finkelstein, Richard A., Fordtran, John S.
To assess the ion transport mechanism by which cholera causes the small bowel to secrete, ion transport rates and electrical potential difference (PD) were determined simultaneously in the normal and...
Virulence of Escherichia coli Strains for Chick Embryos1
Powell, Calvin J., Finkelstein, Richard A.
Powell, Calvin J., Jr. (Walter Reed Army Institute of Research, Washington, D.C.), and Richard A. Finkelstein. Virulence of Escherichia coli strains for chick embryos. J. Bacteriol. 91:1410–1417....
Siderophore Production by Pathogenic Neisseria spp
Yancey, Robert J., Finkelstein, Richard A.
Previous studies have established the importance of iron acquisition to the growth and virulence of Neisseria meningitidis and Neisseria gonorrhoeae. Although preliminary evidence that the Neisseria...
Finkelstein, Richard A., Boesman-Finkelstein, Mary, Holt, Peter
Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut...
Studies on Toxinogenesis in Vibrio cholerae II. An In Vitro Test for Enterotoxin Production
Vasil, Michael L., Holmes, Randall K., Finkelstein, Richard A.
An Elek test for enterotoxin-producing strains of Vibrio cholerae is described. Thirty-five out of 37 strains of classical V. cholerae produced positive reactions, but only 1 of 69 E1 Tor vibrio...
In Vitro Detection of Antibody to Cholera Enterotoxin in Cholera Patients and Laboratory Animals
Finkelstein, Richard A., Peterson, Johnny W.
Two new in vitro microtests for anticholeragen (cholera exo-enterotoxin) antibodies are described and compared. In both tests, choleragen and choleragenoid, antigenically identical purified moieties...
Rabbits immunized with purified antigens, choleragen and choleragenoid (cholera exo-enterotoxin and natural toxoid), were found to resist intra-intestinal challenge with a variety of strains of...
Finkelstein, Richard A., Hollingsworth, Russell C.
The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin...
Monospecific Equine Antiserum Against Cholera Exo-Enterotoxin
An antiserum specific for Vibrio cholerae exo-enterotoxin was produced by immunization of a horse with purified choleragenoid, a natural cholera toxoid. The serum has a high titer against the toxin...
Enteropathogencity of Escherichia coli I. Evaluation of Mouse Intestinal Loops
Punyashthiti, Kannikar, Finkelstein, Richard A.
A ligated mouse intestinal loop assay has been introduced to evaluate the enteropathogenicity of strains of Escherichia coli. When inoculated as whole cultures, 19 (34%) of 55 strains isolated from...
Finkelstein, Richard A., LaRue, Michael K., LoSpalluto, Joseph J.
Initial studies, by using polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), led to the attractive hypothesis that the cholera exo-enterotoxin (choleragen) consisted...
Clements, John D., Finkelstein, Richard A.
Heat-labile enterotoxin from Escherichia coli is immunologically related to both subunits, A and B, of cholera enterotoxin as demonstrated by neutralization and immunodiffusion.
Bumgarner, Linda R., Finkelstein, Richard A.
The virulence of gonococcal strains and colony types was evaluated in embryonated hen eggs of various ages inoculated by different routes. Striking differences in virulence of colony types were...
McCombie, Roberta L., Finkelstein, Richard A., Woods, Donald E.
A collection of 207 historically relevant Burkholderia pseudomallei isolates was analyzed by multilocus sequence typing (MLST). The strain collection contains environmental isolates obtained from a...
Cholera Toxin B Subunit Activates Arachidonic Acid Metabolism
Peterson, Johnny W., Finkelstein, Richard A., Cantu, Juan, Gessell, Deborah L., Chopra, Ashok K.
Cholera toxin (CT) increases intestinal secretion of water and electrolytes and modulates the mucosal immune response by stimulating cellular synthesis of arachidonic acid (AA) metabolites (e.g.,...
Environmental Signals Controlling Production of Hemagglutinin/Protease in Vibrio cholerae
Benitez, Jorge A., Silva, Anisia J., Finkelstein, Richard A.
Vibrio cholerae hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor...
Kossaczka, Zuzana, Shiloach, Joseph, Johnson, Virginia, Taylor, David N., Finkelstein, Richard A., Robbins, John B., ...
Epidemiologic and experimental data provide evidence that a critical level of serum immunoglobulin G (IgG) antibodies to the surface polysaccharide of Vibrio cholerae O1 (lipopolysaccharide) and of...
Jouravleva, Elena A., McDonald, Gregory A., Marsh, Jane W., Taylor, Ronald K., Boesman-Finkelstein, Mary, Finkelstein, Richard A.
We previously isolated from a 1994 isolate of Vibrio cholerae O139 a filamentous lysogenic bacteriophage, choleraphage 493, which inhibits pre-O139 but not post-O139 El Tor biotype V. cholerae...
Payne, Shelley M., Finkelstein, Richard A.
Exceptional strains of gonococci that grow on Congo red agar were found to be penicillin-resistant non-penicillinase producers.
Colonial Recognition, a “New” Approach for Rapid Diagnostic Enteric Bacteriology
Finkelstein, Richard A., Punyashthiti, Kannikar
The morphology, on MacConkey's agar, of colonies of the bacteria commonly found in enteric specimens is sufficiently characteristic and distinctive, when observed with transmitted oblique...
Ion transport during cholera-induced ileal secretion in the dog
Moore, William L., Bieberdorf, Fred A., Morawski, Stephen G., Finkelstein, Richard A., Fordtran, John S.
To assess the ion transport mechanism by which cholera causes the small bowel to secrete, ion transport rates and electrical potential difference (PD) were determined simultaneously in the normal and...
Virulence of Escherichia coli Strains for Chick Embryos1
Powell, Calvin J., Finkelstein, Richard A.
Powell, Calvin J., Jr. (Walter Reed Army Institute of Research, Washington, D.C.), and Richard A. Finkelstein. Virulence of Escherichia coli strains for chick embryos. J. Bacteriol. 91:1410–1417....
Siderophore Production by Pathogenic Neisseria spp
Yancey, Robert J., Finkelstein, Richard A.
Previous studies have established the importance of iron acquisition to the growth and virulence of Neisseria meningitidis and Neisseria gonorrhoeae. Although preliminary evidence that the Neisseria...
Finkelstein, Richard A., Boesman-Finkelstein, Mary, Holt, Peter
Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut...
Studies on Toxinogenesis in Vibrio cholerae II. An In Vitro Test for Enterotoxin Production
Vasil, Michael L., Holmes, Randall K., Finkelstein, Richard A.
An Elek test for enterotoxin-producing strains of Vibrio cholerae is described. Thirty-five out of 37 strains of classical V. cholerae produced positive reactions, but only 1 of 69 E1 Tor vibrio...
In Vitro Detection of Antibody to Cholera Enterotoxin in Cholera Patients and Laboratory Animals
Finkelstein, Richard A., Peterson, Johnny W.
Two new in vitro microtests for anticholeragen (cholera exo-enterotoxin) antibodies are described and compared. In both tests, choleragen and choleragenoid, antigenically identical purified moieties...
Rabbits immunized with purified antigens, choleragen and choleragenoid (cholera exo-enterotoxin and natural toxoid), were found to resist intra-intestinal challenge with a variety of strains of...
Finkelstein, Richard A., Hollingsworth, Russell C.
The recently introduced choleragen-induced rat foot edema model has been employed as a bioassay for evaluating the immunogenicity of three purified preparations containing cholera exo-enterotoxin...
Monospecific Equine Antiserum Against Cholera Exo-Enterotoxin
An antiserum specific for Vibrio cholerae exo-enterotoxin was produced by immunization of a horse with purified choleragenoid, a natural cholera toxoid. The serum has a high titer against the toxin...
Enteropathogencity of Escherichia coli I. Evaluation of Mouse Intestinal Loops
Punyashthiti, Kannikar, Finkelstein, Richard A.
A ligated mouse intestinal loop assay has been introduced to evaluate the enteropathogenicity of strains of Escherichia coli. When inoculated as whole cultures, 19 (34%) of 55 strains isolated from...
Finkelstein, Richard A., LaRue, Michael K., LoSpalluto, Joseph J.
Initial studies, by using polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), led to the attractive hypothesis that the cholera exo-enterotoxin (choleragen) consisted...
Clements, John D., Finkelstein, Richard A.
Heat-labile enterotoxin from Escherichia coli is immunologically related to both subunits, A and B, of cholera enterotoxin as demonstrated by neutralization and immunodiffusion.
Bumgarner, Linda R., Finkelstein, Richard A.
The virulence of gonococcal strains and colony types was evaluated in embryonated hen eggs of various ages inoculated by different routes. Striking differences in virulence of colony types were...
McCombie, Roberta L., Finkelstein, Richard A., Woods, Donald E.
A collection of 207 historically relevant Burkholderia pseudomallei isolates was analyzed by multilocus sequence typing (MLST). The strain collection contains environmental isolates obtained from a...
NON-SPECIFIC RESISTANCE TO EXPERIMENTAL CHOLERA IN EMBRYONATED EGGS
Finkelstein, Richard A., Ransom, John P.
It has been confirmed that 11- and 13-day-old chick embryos are susceptible to lethal infection with minute inocula of V. cholerae, while 15-day-old embryos are relatively resistant. Twenty strains...
PATHOGENESIS OF EXPERIMENTAL CHOLERA : PREPARATION AND ISOLATION OF CHOLERAGEN AND CHOLERAGENOID
Finkelstein, Richard A., LoSpalluto, Joseph J.
Choleragen, a diarrheagenic protein enterotoxin elaborated by Vibrio cholerae, has been isolated from the supernate of fermenter cultures by steps involving ammonium sulfate precipitation, DEAE...
A test of antigenicity for the selection of strains for inclusion in cholera vaccines
Finkelstein, Richard A., Pongpairojana, Smarn
The antigenicity of a large number of cholera vibrio strains was compared, in groups of rabbits, by evaluating the serological responses to single limited doses of vaccines prepared from the strains....
Comparison of methods for the rapid recognition of cholera vibrios
Finkelstein, Richard A., Gomez, Cecilia Z.
A comparison was made of three methods of bacteriological diagnosis during the outbreak of cholera due to Vibrio El Tor in the Republic of the Philippines in the last quarter of 1961. Although the...