Richard A. Klinghoffer

Retention of PDGFR-{beta} function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase C{gamma} signaling pathways (2000)

Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion (1999)

Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...

Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading

Cary, Leslie A., Klinghoffer, Richard A., Sachsenmaier, Christoph, Cooper, Jonathan A.

Src family kinases (SFKs) are crucial for signaling through a variety of cell surface receptors, including integrins. There is evidence that integrin activation induces focal adhesion kinase (FAK)...

Retention of PDGFR-β function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways

Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...

Signal transduction by the platelet-derived growth-factor receptor β (PDGFR-β) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC). However, the importance of...

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...

Eph receptor tyrosine kinases and their corresponding surface-bound ligands, the ephrins, provide cues to the migration of cells and growth cones during embryonic development. Here we show that...

Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms

Hamilton, T. Guy, Klinghoffer, Richard A., Corrin, Philip D., Soriano, Philippe

Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined by RTK...

Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading

Cary, Leslie A., Klinghoffer, Richard A., Sachsenmaier, Christoph, Cooper, Jonathan A.

Src family kinases (SFKs) are crucial for signaling through a variety of cell surface receptors, including integrins. There is evidence that integrin activation induces focal adhesion kinase (FAK)...

Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms

Hamilton, T. Guy, Klinghoffer, Richard A., Corrin, Philip D., Soriano, Philippe

Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined by RTK...

Retention of PDGFR-β function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways

Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...

Signal transduction by the platelet-derived growth-factor receptor β (PDGFR-β) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC). However, the importance of...

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...

Eph receptor tyrosine kinases and their corresponding surface-bound ligands, the ephrins, provide cues to the migration of cells and growth cones during embryonic development. Here we show that...

A Lentivirus-Mediated Genetic Screen Identifies Dihydrofolate Reductase (DHFR) as a Modulator of β-Catenin/GSK3 Signaling

Klinghoffer, Richard A., Frazier, Jason, Annis, James, Berndt, Jason D., Roberts, Brian S., Arthur, William T., ...

The multi-protein β-catenin destruction complex tightly regulates β-catenin protein levels by shuttling β-catenin to the proteasome. Glycogen synthase kinase 3β (GSK3β), a key serine/threonine...