The image in the painting La Bonne Aventure is not a nose (Fig. 1). It is a portrayal by the surrealist René Magritte of his own brain’s representation of the external world. It is a vignette that...
Expression of Candidate Pheromone Receptor Genes in Vomeronasal Neurons (1998)
Dulac, Catherine, Axel, Richard
In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VON). Pheromones activate the...
Expression of odorant receptor genes in the catfish olfactory epithelium (1993)
Ngai, John, Chess, Andrew, Dowling, Michael M., Axel, Richard
A self-reactive T cell population that is not subject to negative selection (1992)
Robey, Ellen A., Ramsdell, Fred, Gordon, Jon W., Mamalaki, Clio, Kioussis, Dimitris, Youn, Hyun J., ...
In male mice expressing a transgenic αβ TCR which recognizes a male antigen (HY), T cells which do not express normal levels of CD8 escape thymic deletion and appear in the periphery. These consist...
Molecular cloning and nucleotide sequence of the streptavidin gene (1986)
Argarana, Carlos E., Kuntz, Irwin D., Birken, Steven, Axel, Richard, Cantor, Charles R.
Using synthetic oligonucleotides as probes we have cloned the streptavidin gene from a genomic library of Streptomyces avidinii. Nucleotide sequence analysis indicated that a 2 Kb DNA-fragment...
Eucaryotic gene regulation / edited by Richard Axel, Tom Maniatis, C. Fred Fox (1979)
Axel, Richard, Maniatis, Tom, Fox, C. Fred
"Proceedings of symposium held in Keysto Keistone, Colo., Mar. 4-9, 1979"
Nucleosomes in metaphase chromosomes (1976)
Wigler, Michael H., Axel, Richard
Previous studies of the structure of metaphase chromosomes have relied heavily on electron micrography and have revealed the existence of a 10-nm unit fiber that is thought to generate the native...
Yang, Jing-Hua, Sklar, Pamela, Axel, Richard, Maniatis, Tom
The glutamate receptor subunit B (GluR-B) pre-mRNA is edited at two adenosine residues, resulting in amino acid changes that alter the electrophysiologic properties of the glutamate receptor....
Bulger, Michael, Von Doorninck, J. Hikke, Saitoh, Noriko, Telling, Agnes, Farrell, Catherine, Bender, M. A., ...
In mouse and human, the β-globin genes reside in a linear array that is associated with a positive regulatory element located 5′ to the genes known as the locus control region (LCR). The sequences...
Genomic analysis of orthologous mouse and human olfactory receptor loci
Lane, Robert P., Cutforth, Tyler, Young, Janet, Athanasiou, Maria, Friedman, Cynthia, Rowen, Lee, ...
Olfactory receptor (OR) genes represent ≈1% of genomic coding sequence in mammals, and these genes are clustered on multiple chromosomes in both the mouse and human genomes. We have taken a...
Lane, Robert P., Cutforth, Tyler, Axel, Richard, Hood, Leroy, Trask, Barbara J.
We have analyzed the organization and sequence of 73 V1R genes encoding putative pheromone receptors to identify regulatory features and characterize the evolutionary history of the V1R family. The...
Altered sexual and social behaviors in trp2 mutant mice
Leypold, Bradley G., Yu, C. Ron, Leinders-Zufall, Trese, Kim, Michelle M., Zufall, Frank, Axel, Richard
We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the...
Stability of Ribosomes and Ribosomal Ribonucleic Acid from Bacillus stearothermophilus1
Friedman, S. Marvin, Axel, Richard, Weinstein, I. Bernard
After heating at 65 C, ribosomes isolated from Bacillus stearothermophilus were strikingly more heat-stable than comparable preparations from Escherichia coli when tested for ability to support...
Pellicer, Angel, Wagner, Erwin F., Kareh, Adele El, Dewey, Michael J., Reuser, Arnold J., Silverstein, Saul, ...
Teratocarcinoma (TCC) stem cells provide unique prospects for the introduction of specific genes into mice, by virtue of their dual capacity for propagation in vitro and for normal differentiation in...
Intragenic DNA spacers interrupt the ovalbumin gene
Weinstock, Ruth, Sweet, Raymond, Weiss, Michael, Cedar, Howard, Axel, Richard
We have performed restriction endonuclease mapping to examine the linear organization of the ovalbumin gene in chromosomal DNA. Treatment of genomic DNA with restriction endonucleases that do not...
Genes transcribed at diverse rates have a similar conformation in chromatin
Garel, Annie, Zolan, Miriam, Axel, Richard
We have analyzed the DNA generated upon treatment of oviduct nuclei with pancreatic DNase I (deoxyribonucleate 3′-oligonucleotidohydrolase; EC 3.1.4.6), with cDNA copies of specific mRNA sequences...
Synthesis of Globin Ribonucleic Acid from Duck-Reticulocyte Chromatin In Vitro
Axel, Richard, Cedar, Howard, Felsenfeld, Gary
The proteins of chromatin serve to restrict the transcription of DNA. The relevance of these findings to the control of gene expression is contingent upon the demonstration that this restriction is...
Yang, Jing-Hua, Sklar, Pamela, Axel, Richard, Maniatis, Tom
The glutamate receptor subunit B (GluR-B) pre-mRNA is edited at two adenosine residues, resulting in amino acid changes that alter the electrophysiologic properties of the glutamate receptor....
Bulger, Michael, Von Doorninck, J. Hikke, Saitoh, Noriko, Telling, Agnes, Farrell, Catherine, Bender, M. A., ...
In mouse and human, the β-globin genes reside in a linear array that is associated with a positive regulatory element located 5′ to the genes known as the locus control region (LCR). The sequences...
Genomic analysis of orthologous mouse and human olfactory receptor loci
Lane, Robert P., Cutforth, Tyler, Young, Janet, Athanasiou, Maria, Friedman, Cynthia, Rowen, Lee, ...
Olfactory receptor (OR) genes represent ≈1% of genomic coding sequence in mammals, and these genes are clustered on multiple chromosomes in both the mouse and human genomes. We have taken a...
Lane, Robert P., Cutforth, Tyler, Axel, Richard, Hood, Leroy, Trask, Barbara J.
We have analyzed the organization and sequence of 73 V1R genes encoding putative pheromone receptors to identify regulatory features and characterize the evolutionary history of the V1R family. The...
Altered sexual and social behaviors in trp2 mutant mice
Leypold, Bradley G., Yu, C. Ron, Leinders-Zufall, Trese, Kim, Michelle M., Zufall, Frank, Axel, Richard
We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the...
Stability of Ribosomes and Ribosomal Ribonucleic Acid from Bacillus stearothermophilus1
Friedman, S. Marvin, Axel, Richard, Weinstein, I. Bernard
After heating at 65 C, ribosomes isolated from Bacillus stearothermophilus were strikingly more heat-stable than comparable preparations from Escherichia coli when tested for ability to support...
Pellicer, Angel, Wagner, Erwin F., Kareh, Adele El, Dewey, Michael J., Reuser, Arnold J., Silverstein, Saul, ...
Teratocarcinoma (TCC) stem cells provide unique prospects for the introduction of specific genes into mice, by virtue of their dual capacity for propagation in vitro and for normal differentiation in...
Intragenic DNA spacers interrupt the ovalbumin gene
Weinstock, Ruth, Sweet, Raymond, Weiss, Michael, Cedar, Howard, Axel, Richard
We have performed restriction endonuclease mapping to examine the linear organization of the ovalbumin gene in chromosomal DNA. Treatment of genomic DNA with restriction endonucleases that do not...
Genes transcribed at diverse rates have a similar conformation in chromatin
Garel, Annie, Zolan, Miriam, Axel, Richard
We have analyzed the DNA generated upon treatment of oviduct nuclei with pancreatic DNase I (deoxyribonucleate 3′-oligonucleotidohydrolase; EC 3.1.4.6), with cDNA copies of specific mRNA sequences...
Synthesis of Globin Ribonucleic Acid from Duck-Reticulocyte Chromatin In Vitro
Axel, Richard, Cedar, Howard, Felsenfeld, Gary
The proteins of chromatin serve to restrict the transcription of DNA. The relevance of these findings to the control of gene expression is contingent upon the demonstration that this restriction is...
Mancia, Filippo, Brenner-Morton, Susan, Siegel, Risa, Assur, Zahra, Sun, Yonghua, Schieren, Ira, ...
mAbs that are sensitive to protein conformation can be helpful in studies of protein structure and function; in particular, mAb fragments are useful reagents in membrane protein crystallization. We...
The genetic design of signaling cascades to record receptor activation
Barnea, Gilad, Strapps, Walter, Herrada, Gilles, Berman, Yemiliya, Ong, Jane, Kloss, Brian, ...
We have developed an experimental strategy to monitor protein interactions in a cell with a high degree of selectivity and sensitivity. A transcription factor is tethered to a membrane-bound receptor...