Richard C. M. Siow

Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease (2008)

Rodford, Joanne L., Torrens, Christopher, Siow, Richard C.M., Mann, Giovanni E., Hanson, Mark A., Clough, Geraldine F.

Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...

Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression (2007)

Mann, Giovanni E., Rowlands, David J., Li, Francois Y.L., De Winter, Patricia, Siow, Richard C.M.

The endothelium plays a key role in the maintenance of vascular homeostasis, and increased oxidative stress in vascular disease leads to reduced nitric oxide bioavailability and impaired...

Adventitial growth factor signalling and vascular remodelling: Potential of perivascular gene transfer from the outside-in (2007)

Siow, Richard C.M., Churchman, Adrian T.

The adventitial segment of the vessel wall has received limited attention compared the endothelium, media and neointima in processes involved in vascular remodelling during atherogenesis, coronary...

In utero protein restriction leads to a down-regulation of antioxidant gene expression in adult male offspring (2006)

Rodford, Joanne, Li, Francois Y., Siow, Richard C.M., Hanson, Mark A., Mann, Giovanni E., Clough, Geraldine F.

In rats, restriction of dietary protein during pregnancy leads to raised blood pressure, impaired vasodilatation (Brawley et al. 2003) and increased oxidative damage (increased protein carbonyl...

Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries (2003)

Siow, Richard C.M, Mallawaarachchi, Chandike M, Weissberg, Peter L

Objectives: Migration of adventitial fibroblasts, in addition to smooth muscle cell proliferation, plays a role in neointima formation following vascular injury. Previous studies have not directly...

Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? (1999)

Siow, Richard C.M., Sato, Hideyo, Mann, Giovanni E.

Atherosclerosis is a major contributor to cardiovascular disease, and genetic disorders of lipoprotein metabolism are recognized risk factors in atherogenesis. The gaseous monoxides nitric oxide (NO)...

Mechanisms underlying β2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells

Queen, Lindsay R, Ji, Yong, Xu, Biao, Young, Lora, Yao, Kang, Wyatt, Amanda W, ...

Endothelial β2-adrenoceptor (β2AR) stimulation increases nitric oxide (NO) generation, but the underlying cellular mechanisms are unclear. We examined the role of l-arginine transport and of...

Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease

Rodford, Joanne L, Torrens, Christopher, Siow, Richard C M, Mann, Giovanni E, Hanson, Mark A, Clough, Geraldine F

Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...