Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus (2008)
Foy, Michael R., Akopian, Garnik, Thompson, Richard F.
Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with...
Decremental effects of context exposure following delay eyeblink conditioning in rabbits (2006)
Poulos, Andrew M, Pakaprot, Narawut, Mahdi, Benjamin, Kehoe, E James, Thompson, Richard F
The conditioning context arises from the relatively static features of the training environment. In rabbit eyeblink conditioning, procedures that retard acquisition (conditioned stimulus [CS]...
Neural Substrates of Eyeblink Conditioning: Acquisition and Retention (2003)
Christian, Kimberly M., Thompson, Richard F.
Classical conditioning of the eyeblink reflex to a neutral stimulus that predicts an aversive stimulus is a basic form of associative learning. Acquisition and retention of this learned response...
Effects of Paired and Unpaired Eye-Blink Conditioning on Purkinje Cell Morphology (1999)
Anderson, Brenda J., Relucio, Karen, Haglund, Karl, Logan, Christy, Knowlton, Barbara, Thompson, Judith, ...
Theoretical and Experimental Analysis of the Neural Bases for Learning and Memory. (1998)
Thompson, Richard F., Solomon, Herbert
Our ONR supported empirical work during the past five years has focused on identification of the essential i.e., the necessary and sufficient, neural memory trace circuitry and the essential memory...
A Biological Neural Network Analysis of Learning and Memory. (1998)
The basic goal of our research program is to localize and analyze processes and mechanisms of memory formation, storage and retrieval in the mammalian brain. We focus on associative learning and...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency (1998)
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the alpha -subunit of the heterotrimeric guanine nucleotide binding protein Gq (Galpha q) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the alpha-subunit of the heterotrimeric guanine nucleotide binding protein G(q) (G alpha(q)) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
This research supported by the Office of Naval Research was focussed on how memories for the learning of skilled sensory-motor behaviors are learned, where they are stored in the brain and how these...
Maren, Stephen, Tocco, Georges, Chavanne, Frederic, Baudry, Michel, Thompson, Richard F., Mitchell, Denis
Previous work from our laboratory indicated that emergence neophobia is highly correlated with perforant path long-term potentiation (LTP) in rats. In the present study, we examined the relationship...
Maren, Stephen, DeCola, Joseph P., Swain, Rodney A., Fanselow, Michael S., Thompson, Richard F.
The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and...
Maren, Stephen, Tocco, Georges, Standley, Steven, Baudry, Michel, Thompson, Richard F.
Several lines of evidence indicate that LTP in the hippocampus is associated with a change in the properties of postsynaptic glutamate receptors. In the present study, we used quantitative...
Maren, Stephen, Patel, Ketan, Thompson, Richard F., Mitchell, Denis
Emergence neophobia was assessed in an emergence apparatus that provided a choice between novel and familiar alternatives. Two weeks following emergence testing the threshold to induce perforant path...
Maren, Stephen, Baudry, Michel, Thompson, Richard F.
The effects of the novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, CGP 39551 [the carboxyethylester of CGP 37849; DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid], on...
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus (1992)
Tocco, Georges, Maren, Stephen, Shors, Tracey J., Baudry, Michel, Thompson, Richard F.
The location and nature of the changes underlying long-term potentiation (LTP) remain controversial issues. In this study, we tested the possibility that changes in binding properties of the...
Schreiber, Steven S., Maren, Stephen, Tocco, Georges, Shors, Tracey J., Thompson, Richard F.
In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos...
Differential effects of ketamine and MK-801 on the induction of long-term potentiation (1991)
Maren, Stephen, Baudry, Michel, Thompson, Richard F.
Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel....
Basic Behavioral Sciences (1988)
Holzman, Philip S., Bivens, Lyle W., Bower, Gordon H., Campos, Joseph J., Carpenter, Patricia, Ekman, Paul, ...
Psicología : guía de estudio / Gardner Lindzey, Calvin S. Hall, Richard F. Thompson (1978)
Lindzey, Gardner, Hall, Calvin S, Thompson, Richard F
Traducción de: Study guide for psychology
Introducción a la psicología fisiológica (1977)
Traducción de: Introduction to physiological psychology
Introducción a la psicología fisiológica / R.F. Thompson; tr. por: Rodrigo Naranjo Vallejo. (1977)
Traducción de: Introduction to physiological psychology
Fundamentos de psicología fisiológica (1973)
Traducción de: Foundations of Physiological Psychology
Fundamentos de psicología fisiológica / R.F. Thompson ; tr. por Augusto Fernández Guardiola. (1973)
Traducción de: Foundations of Physiological Psychology
Fundamentos de psicología fisiológica / Richard F. Thompson (1973)
Traducción de: Foundations of physiological psychology
Thesis--University of Virginia, 1972.
Psicología fisiológica / introducciones de Richard F. Thompson (1971)
Traducción del inglés
Typescript.
Bi, Ruifen, Broutman, Greg, Foy, Mike R., Thompson, Richard F., Baudry, Michel
Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. The present study indicates that estrogen is neuroprotective...
Chen, Lu, Bao, Shaowen, Qiao, Xiaoxi, Thompson, Richard F.
The waggler, a neurological mutant mouse with a disrupted putative neuronal Ca2+ channel γ subunit, exhibits a cerebellar granule cell-specific brain-derived neurotrophic factor deficit, severe...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway
Bi, Ruifen, Foy, Michael R., Vouimba, Rose-Marie, Thompson, Richard F., Baudry, Michel
Hippocampal synaptic structure and function exhibit marked variations during the estrus cycle of female rats. Estradiol activates the mitogen-activated protein (MAP) kinase pathway in numerous cell...
Cerebellar cortical inhibition and classical eyeblink conditioning
Bao, Shaowen, Chen, Lu, Kim, Jeansok J., Thompson, Richard F.
The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance...
Liu, Ruolan, Liu, Ingrid Y., Bi, Xiaoning, Thompson, Richard F., Doctrow, Susan R., Malfroy, Bernard, ...
Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain...
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
In addition to their trophic functions, neurotrophins are also implicated in synaptic modulation and learning and memory. Although gene knockout techniques have been used widely in studying the roles...
Effects of Paired and Unpaired Eye-Blink Conditioning on Purkinje Cell Morphology
Anderson, Brenda J., Relucio, Karen, Haglund, Karl, Logan, Christy, Knowlton, Barbara, Thompson, Judith, ...
This experiment addressed (1) the importance of conjunctive stimulus presentation for morphological plasticity of cerebellar Purkinje cells and inhibitory interneurons and (2) whether plasticity is...
Transgenic Brain-Derived Neurotrophic Factor Modulates a Developing Cerebellar Inhibitory Synapse
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Thompson, Richard F.
Brain-derived neurotrophic factor (BDNF) has been shown to promote synapse formation and maturation in neurons of many brain regions, including inhibitory synapses. In the cerebellum, the Golgi...
Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice
Park, Jin-Sung, Onodera, Takashi, Nishimura, Shin-ichi, Thompson, Richard F., Itohara, Shigeyoshi
The anterior interpositus nucleus (AIN) is the proposed site of memory formation of eyeblink conditioning. A large part of the underlying molecular events, however, remain unknown. To elucidate the...
Bi, Ruifen, Broutman, Greg, Foy, Mike R., Thompson, Richard F., Baudry, Michel
Estrogen replacement therapy in women is associated with improvement of cognitive deficits and reduced incidence of Alzheimer's disease. The present study indicates that estrogen is neuroprotective...
Chen, Lu, Bao, Shaowen, Qiao, Xiaoxi, Thompson, Richard F.
The waggler, a neurological mutant mouse with a disrupted putative neuronal Ca2+ channel γ subunit, exhibits a cerebellar granule cell-specific brain-derived neurotrophic factor deficit, severe...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway
Bi, Ruifen, Foy, Michael R., Vouimba, Rose-Marie, Thompson, Richard F., Baudry, Michel
Hippocampal synaptic structure and function exhibit marked variations during the estrus cycle of female rats. Estradiol activates the mitogen-activated protein (MAP) kinase pathway in numerous cell...
Cerebellar cortical inhibition and classical eyeblink conditioning
Bao, Shaowen, Chen, Lu, Kim, Jeansok J., Thompson, Richard F.
The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance...
Liu, Ruolan, Liu, Ingrid Y., Bi, Xiaoning, Thompson, Richard F., Doctrow, Susan R., Malfroy, Bernard, ...
Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain...
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
In addition to their trophic functions, neurotrophins are also implicated in synaptic modulation and learning and memory. Although gene knockout techniques have been used widely in studying the roles...
Effects of Paired and Unpaired Eye-Blink Conditioning on Purkinje Cell Morphology
Anderson, Brenda J., Relucio, Karen, Haglund, Karl, Logan, Christy, Knowlton, Barbara, Thompson, Judith, ...
This experiment addressed (1) the importance of conjunctive stimulus presentation for morphological plasticity of cerebellar Purkinje cells and inhibitory interneurons and (2) whether plasticity is...
Transgenic Brain-Derived Neurotrophic Factor Modulates a Developing Cerebellar Inhibitory Synapse
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Thompson, Richard F.
Brain-derived neurotrophic factor (BDNF) has been shown to promote synapse formation and maturation in neurons of many brain regions, including inhibitory synapses. In the cerebellum, the Golgi...
Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice
Park, Jin-Sung, Onodera, Takashi, Nishimura, Shin-ichi, Thompson, Richard F., Itohara, Shigeyoshi
The anterior interpositus nucleus (AIN) is the proposed site of memory formation of eyeblink conditioning. A large part of the underlying molecular events, however, remain unknown. To elucidate the...
Weeks, Andrew C.W., Connor, Steve, Hinchcliff, Richard, LeBoutillier, Janelle C., Thompson, Richard F., Petit, Ted L.
Eye-blink conditioning involves the pairing of a conditioned stimulus (usually a tone) to an unconditioned stimulus (air puff), and it is well established that an intact cerebellum and interpositus...
Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus
Foy, Michael R., Akopian, Garnik, Thompson, Richard F.
Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with...