on Aging By implementing (2008)
this Checklist, web designers can help open the Internet to great numbers of people over 60 who want to know more about their health and aging.
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence (2008)
Nakamura, Asako J, Chiang, Y Jeffrey, Hathcock, Karen S, Horikawa, Izumi, Sedelnikova, Olga A, Hodes, Richard J, ...
Abstract Background Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including...
Transcriptome Analysis of Mouse Stem Cells and Early Embryos (2003)
Alexei A. Sharov, Yulan Piao, Ryo Matoba, Dawood B. Dudekula, Yong Qian, Vincent VanBuren, ...
250,000 EST sequences from oocytes, blastocysts, and embryonic and adult stem cells contribute to the annotation of the mouse genome and suggest genes that contribute to the unique features of these...
Transcriptome Analysis of Mouse Stem Cells and Early Embryos (2003)
Alexei A. Sharov, Yulan Piao, Ryo Matoba, Dawood B. Dudekula, Yong Qian, Vincent VanBuren, ...
Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...
CD44 isoform expression mediated by alternative splicing: tissue-specific regulation in mice (1994)
Hirano, Hiroyuki, Screaton, Gran R., Bell, Martyn V., Jackson, David G., Bell, John J., Hodes, Richard J.
CD44 is a widely distributed cell surface glycoproteln which shows heterogeneity in molecular expression as a result of post-translatlonal modification as well as alternative splicing of CD44 mRNA....
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, Lingxiang, Hathcock, Karen S., Hande, Prakash, Lansdorp, Peter M., Seldin, Michael F., Hodes, Richard J.
Little is known about the mechanisms that regulate species-specific telomere length, particularly in mammalian species. The genetic regulation of telomere length was therefore investigated by using...
Liu, Kebin, Schoonmaker, Michele M., Levine, Bruce L., June, Carl H., Hodes, Richard J., Weng, Nan-ping
Human telomerase consists of two essential components, telomerase RNA template (hTER) and telomerase reverse transcriptase (hTERT), and functions to synthesize telomere repeats that serve to protect...
Telomere lengthening and telomerase activation during human B cell differentiation
Weng, Nan-ping, Granger, Lawrence, Hodes, Richard J.
The function of the immune system is highly dependent on cellular differentiation and clonal expansion of antigen-specific lymphocytes. However, little is known about mechanisms that may have evolved...
Haploinsufficiency of mTR results in defects in telomere elongation
Hathcock, Karen S., Hemann, Michael T., Opperman, Kay Keyer, Strong, Margaret A., Greider, Carol W., Hodes, Richard J.
Telomeres are usually maintained about an equilibrium length, and the set point for this equilibrium differs between species and between strains of a given species. To examine the requirement for...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Transcriptome Analysis of Mouse Stem Cells and Early Embryos
Sharov, Alexei A, Piao, Yulan, Matoba, Ryo, Dudekula, Dawood B, Qian, Yong, VanBuren, Vincent, ...
Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...
Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Williams, Joy A., Hathcock, Karen S., Klug, David, Harada, Yohsuke, Choudhury, Baishakhi, Allison, James P., ...
Expression of CD28 is highly regulated during thymic development, with CD28 levels extremely low on immature thymocytes but increasing dramatically as CD4−CD8− cells initiate expression of TCRβ....
Zhou, Juhua, Shen, Xinglei, Hodes, Richard J., Rosenberg, Steven A., Robbins, Paul F.
Recent studies have indicated that adoptive immunotherapy with autologous anti-tumor tumor-infiltrating lymphocytes (TILs) following non-myeloablative chemotherapy mediates tumor regression in...
Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice
Chiang, Y. Jeffrey, Nguyen, My-Linh, Gurunathan, Sujatha, Kaminker, Patrick, Tessarollo, Lino, Campisi, Judith, ...
Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in...
Response to: “Rescuing the NIH before it is too late”
Alexander, Duane F., Alving, Barbara M., Battey, James F., Berg, Jeremy M., Collins, Francis S., Fauci, Anthony S., ...
We, the directors of the 27 NIH institutes and centers, wanted to respond to the points made by Andrew Marks in his recent editorial. While we appreciate that the scientific community has concerns,...
Horikawa, Izumi, Chiang, Y. Jeffrey, Patterson, Tricia, Feigenbaum, Lionel, Leem, Sun-Hee, Michishita, Eriko, ...
In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, Lingxiang, Hathcock, Karen S., Hande, Prakash, Lansdorp, Peter M., Seldin, Michael F., Hodes, Richard J.
Little is known about the mechanisms that regulate species-specific telomere length, particularly in mammalian species. The genetic regulation of telomere length was therefore investigated by using...
Liu, Kebin, Schoonmaker, Michele M., Levine, Bruce L., June, Carl H., Hodes, Richard J., Weng, Nan-ping
Human telomerase consists of two essential components, telomerase RNA template (hTER) and telomerase reverse transcriptase (hTERT), and functions to synthesize telomere repeats that serve to protect...
Telomere lengthening and telomerase activation during human B cell differentiation
Weng, Nan-ping, Granger, Lawrence, Hodes, Richard J.
The function of the immune system is highly dependent on cellular differentiation and clonal expansion of antigen-specific lymphocytes. However, little is known about mechanisms that may have evolved...
Haploinsufficiency of mTR results in defects in telomere elongation
Hathcock, Karen S., Hemann, Michael T., Opperman, Kay Keyer, Strong, Margaret A., Greider, Carol W., Hodes, Richard J.
Telomeres are usually maintained about an equilibrium length, and the set point for this equilibrium differs between species and between strains of a given species. To examine the requirement for...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Transcriptome Analysis of Mouse Stem Cells and Early Embryos
Sharov, Alexei A, Piao, Yulan, Matoba, Ryo, Dudekula, Dawood B, Qian, Yong, VanBuren, Vincent, ...
Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a...
Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Horikawa, Izumi, Chiang, Y. Jeffrey, Patterson, Tricia, Feigenbaum, Lionel, Leem, Sun-Hee, Michishita, Eriko, ...
In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire...
Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice
Chiang, Y. Jeffrey, Nguyen, My-Linh, Gurunathan, Sujatha, Kaminker, Patrick, Tessarollo, Lino, Campisi, Judith, ...
Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in...
Response to: “Rescuing the NIH before it is too late”
Alexander, Duane F., Alving, Barbara M., Battey, James F., Berg, Jeremy M., Collins, Francis S., Fauci, Anthony S., ...
We, the directors of the 27 NIH institutes and centers, wanted to respond to the points made by Andrew Marks in his recent editorial. While we appreciate that the scientific community has concerns,...
Vacchio, Melanie S., Olaru, Alexandru, Livak, Ferenc, Hodes, Richard J.
The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in...
Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
Lumsden, Joanne M., McCarty, Thomas, Petiniot, Lisa K., Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A., ...
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein...
Chiang, Y. Jeffrey, Sommers, Connie L., Jordan, Martha S., Gu, Hua, Samelson, Lawrence E., Koretzky, Gary A., ...
c-Cbl is an adaptor protein that negatively regulates signal transduction events involved in thymic-positive selection. To further characterize the function of c-Cbl in T cell development, we...
CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
Vacchio, Melanie S., Hodes, Richard J.
Whereas ligation of CD28 is known to provide a critical costimulatory signal for activation of CD4 T cells, the requirement for CD28 as a costimulatory signal during activation of CD8 cells is less...
Hodes, Richard J., Handwerger, Barry S., Terry, William D.
Two subpopulations separated from normal spleen have been shown to synergize as responding cells in the in vitro induction of specific cell-mediated cytotoxicity during the mixed lymphocyte culture...
Palmer, Larry D., Weng, Nan-ping, Levine, Bruce L., June, Carl H., Lane, H. Clifford, Hodes, Richard J.
To address the possible role of replicative senescence in human immunodeficiency virus (HIV) infection, telomere length, telomerase activity, and in vitro replicative capacity were assessed in...
Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1
Yang, Liang Peng, Riley, James L., Carroll, Richard G., June, Carl H., Hoxie, James, Patterson, Bruce K., ...
CD8+ T lymphocytes confer significant but ultimately insufficient protection against HIV infection. Here we report that activated neonatal CD8+ T cells can be productively infected in vitro by...
Tankyrase 1 and Tankyrase 2 Are Essential but Redundant for Mouse Embryonic Development
Chiang, Y. Jeffrey, Hsiao, Susan J., Yver, Dena, Cushman, Samuel W., Tessarollo, Lino, Smith, Susan, ...
Tankyrases are proteins with poly(ADP-ribose) polymerase activity. Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length,...
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
Nakamura, Asako J, Chiang, Y Jeffrey, Hathcock, Karen S, Horikawa, Izumi, Sedelnikova, Olga A, Hodes, Richard J, ...
Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation*S⃞
Chiang, Y. Jeffrey, Jordan, Martha S., Horai, Reiko, Schwartzberg, Pamela L., Koretzky, Gary A., Hodes, Richard J.
A signaling pathway involving ZAP-70, LAT, and SLP76 has been regarded as essential for receptor-driven T cell development and activation. Consistent with this model, mice deficient in SLP76 have a...