Young, Samuel M., Samulski, Richard Jude
Adeno-associated virus (AAV) is the only known eukaryotic virus capable of targeted integration in human cells. An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the...
Xiao, Xiao, Li, Juan, Samulski, Richard Jude
Recently, efficient and long-term in vivo gene transfer by recombinant adeno-associated virus type 2 (rAAV) vectors has been demonstrated in a variety of tissues. Further improvement in vector titer...
Gavin, Denise K., Young, Samuel M., Xiao, Weidong, Temple, Brenda, Abernathy, Corinne R., Pereira, Daniel J., ...
Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination
Young, Samuel M., McCarty, Douglas M., Degtyareva, Natalya, Samulski, Richard Jude
Adeno-associated virus type 2 (AAV) is the only known eucaryotic virus capable of targeted integration in human cells. AAV integrates preferentially into human chromosome (ch) 19q13.3qter. The...
Gavin, Denise K., Young, Samuel M., Xiao, Weidong, Temple, Brenda, Abernathy, Corinne R., Pereira, Daniel J., ...
The adeno-associated virus type 2 (AAV) replication (Rep) proteins Rep78 and 68 (Rep78/68) exhibit a number of biochemical activities required for AAV replication, including specific binding to a...
Haberman, Rebecca P., McCown, Thomas J., Samulski, Richard Jude
Adeno-associated virus (AAV) type 2 vectors transfer stable, long-term gene expression to diverse cell types in vivo. Many gene therapy applications require the control of long-term transgene...
Summerford, Candace, Samulski, Richard Jude
The human parvovirus adeno-associated virus (AAV) infects a broad range of cell types, including human, nonhuman primate, canine, murine, and avian. Although little is known about the initial events...
Adeno-associated virus vectors: potential applications for cancer gene therapy
Li, Chengwen, Bowles, Dawn E, Van Dyke, Terry, Samulski, Richard Jude
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success in animal models. The primary hurdle of fully exploiting the arsenal of molecular targets and...
Young, Samuel M., Samulski, Richard Jude
Adeno-associated virus (AAV) is the only known eukaryotic virus capable of targeted integration in human cells. An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the...
Xiao, Xiao, Li, Juan, Samulski, Richard Jude
Recently, efficient and long-term in vivo gene transfer by recombinant adeno-associated virus type 2 (rAAV) vectors has been demonstrated in a variety of tissues. Further improvement in vector titer...
Gavin, Denise K., Young, Samuel M., Xiao, Weidong, Temple, Brenda, Abernathy, Corinne R., Pereira, Daniel J., ...
Roles of Adeno-Associated Virus Rep Protein and Human Chromosome 19 in Site-Specific Recombination
Young, Samuel M., McCarty, Douglas M., Degtyareva, Natalya, Samulski, Richard Jude
Adeno-associated virus type 2 (AAV) is the only known eucaryotic virus capable of targeted integration in human cells. AAV integrates preferentially into human chromosome (ch) 19q13.3qter. The...
Gavin, Denise K., Young, Samuel M., Xiao, Weidong, Temple, Brenda, Abernathy, Corinne R., Pereira, Daniel J., ...
The adeno-associated virus type 2 (AAV) replication (Rep) proteins Rep78 and 68 (Rep78/68) exhibit a number of biochemical activities required for AAV replication, including specific binding to a...
Haberman, Rebecca P., McCown, Thomas J., Samulski, Richard Jude
Adeno-associated virus (AAV) type 2 vectors transfer stable, long-term gene expression to diverse cell types in vivo. Many gene therapy applications require the control of long-term transgene...
Summerford, Candace, Samulski, Richard Jude
The human parvovirus adeno-associated virus (AAV) infects a broad range of cell types, including human, nonhuman primate, canine, murine, and avian. Although little is known about the initial events...
Wu, Zhijian, Miller, Edward, Agbandje-McKenna, Mavis, Samulski, Richard Jude
Recombinant adeno-associated viruses (AAVs) are promising vectors in the field of gene therapy. Different AAV serotypes display distinct tissue tropism, believed to be related to the distribution of...
Wang, Jinhui, Xie, Jing, Lu, Hui, Chen, Lingxia, Hauck, Bernd, Samulski, Richard Jude, ...
Previous studies have documented that 0.1≈1% of input recombinant adeno-associated virus (rAAV) vectors could be stabilized and lead to transgene expression. To characterize the steps involving...