Stuttgart, Univ., Diss., 1999.
Bordallo, Javier, Plemper, Richard K., Finger, Andreas, Wolf, Dieter H.
We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3–1 mutant defective in the degradation of a...
Characterization of a Region of the Measles Virus Hemagglutinin Sufficient for Its Dimerization
Plemper, Richard K., Hammond, Anthea L., Cattaneo, Roberto
Attachment of measles virus (MV) to its cellular receptor is mediated by the viral envelope glycoprotein hemagglutinin (H). H exists at the viral surface as a disulfide-linked dimer which may...
Hammond, Anthea L., Plemper, Richard K., Zhang, Jie, Schneider, Urs, Russell, Stephen J., Cattaneo, Roberto
To redirect the tropism of the vaccine strain of measles virus (MV), Edmonston B, to a targeted cell population, we displayed on the viral hemagglutinin (H) a single-chain antibody (scAb) specific...
Strength of Envelope Protein Interaction Modulates Cytopathicity of Measles Virus
Plemper, Richard K., Hammond, Anthea L., Gerlier, Denis, Fielding, Adele K., Cattaneo, Roberto
To understand the molecular determinants of measles virus (MV) cytopathicity, we have characterized mutant viruses exhibiting a more-extensive cell-to-cell fusion while maintaining efficient...
Plemper, Richard K., Compans, Richard W.
The fusion (F) glycoproteins of measles virus strains Edmonston (MV-Edm) and wtF (MV-wtF) confer distinct cytopathic effects and strengths of hemagglutinin (H) interaction on a recombinant MV-Edm...
A target site for template-based design of measles virus entry inhibitors
Plemper, Richard K., Erlandson, Karl J., Lakdawala, Ami S., Sun, Aiming, Prussia, Andrew, Boonsombat, Jutatip, ...
Measles virus (MV) constitutes a principal cause of worldwide mortality, accounting for almost 1 million deaths annually. Although a live-attenuated vaccine protects against MV, vaccination...
Atypical Fusion Peptide of Nelson Bay Virus Fusion-Associated Small Transmembrane Protein
Cheng, LiTing T., Plemper, Richard K., Compans, Richard W.
A 10-kDa nonstructural transmembrane protein (p10) encoded by a reovirus, Nelson Bay virus, has been shown to induce syncytium formation (34). Sequence analysis and structural studies identified p10...
Design of a Small-Molecule Entry Inhibitor with Activity against Primary Measles Virus Strains
Plemper, Richard K., Doyle, Joshua, Sun, Aiming, Prussia, Andrew, Cheng, Li-Ting, Rota, Paul A., ...
The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in...
Doyle, Joshua, Prussia, Andrew, White, Laura K., Sun, Aiming, Liotta, Dennis C., Snyder, James P., ...
Most viral glycoproteins mediating membrane fusion adopt a metastable native conformation and undergo major conformational changes during fusion. We previously described a panel of compounds that...
Bordallo, Javier, Plemper, Richard K., Finger, Andreas, Wolf, Dieter H.
We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3–1 mutant defective in the degradation of a...
Characterization of a Region of the Measles Virus Hemagglutinin Sufficient for Its Dimerization
Plemper, Richard K., Hammond, Anthea L., Cattaneo, Roberto
Attachment of measles virus (MV) to its cellular receptor is mediated by the viral envelope glycoprotein hemagglutinin (H). H exists at the viral surface as a disulfide-linked dimer which may...
Hammond, Anthea L., Plemper, Richard K., Zhang, Jie, Schneider, Urs, Russell, Stephen J., Cattaneo, Roberto
To redirect the tropism of the vaccine strain of measles virus (MV), Edmonston B, to a targeted cell population, we displayed on the viral hemagglutinin (H) a single-chain antibody (scAb) specific...
Strength of Envelope Protein Interaction Modulates Cytopathicity of Measles Virus
Plemper, Richard K., Hammond, Anthea L., Gerlier, Denis, Fielding, Adele K., Cattaneo, Roberto
To understand the molecular determinants of measles virus (MV) cytopathicity, we have characterized mutant viruses exhibiting a more-extensive cell-to-cell fusion while maintaining efficient...
Plemper, Richard K., Compans, Richard W.
The fusion (F) glycoproteins of measles virus strains Edmonston (MV-Edm) and wtF (MV-wtF) confer distinct cytopathic effects and strengths of hemagglutinin (H) interaction on a recombinant MV-Edm...
A target site for template-based design of measles virus entry inhibitors
Plemper, Richard K., Erlandson, Karl J., Lakdawala, Ami S., Sun, Aiming, Prussia, Andrew, Boonsombat, Jutatip, ...
Measles virus (MV) constitutes a principal cause of worldwide mortality, accounting for almost 1 million deaths annually. Although a live-attenuated vaccine protects against MV, vaccination...
Atypical Fusion Peptide of Nelson Bay Virus Fusion-Associated Small Transmembrane Protein
Cheng, LiTing T., Plemper, Richard K., Compans, Richard W.
A 10-kDa nonstructural transmembrane protein (p10) encoded by a reovirus, Nelson Bay virus, has been shown to induce syncytium formation (34). Sequence analysis and structural studies identified p10...
Design of a Small-Molecule Entry Inhibitor with Activity against Primary Measles Virus Strains
Plemper, Richard K., Doyle, Joshua, Sun, Aiming, Prussia, Andrew, Cheng, Li-Ting, Rota, Paul A., ...
The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in...
Doyle, Joshua, Prussia, Andrew, White, Laura K., Sun, Aiming, Liotta, Dennis C., Snyder, James P., ...
Most viral glycoproteins mediating membrane fusion adopt a metastable native conformation and undergo major conformational changes during fusion. We previously described a panel of compounds that...
Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity▿ †
White, Laura K., Yoon, Jeong-Joong, Lee, Jin K., Sun, Aiming, Du, Yuhong, Fu, Haian, ...
Paramyxoviruses comprise several major human pathogens. Although a live-attenuated vaccine protects against measles virus (MV), a member of the paramyxovirus family, the virus remains a principal...
Lee, Jin K., Prussia, Andrew, Snyder, James P., Plemper, Richard K.
In search of target sites for the development of paramyxovirus inhibitors, we have engineered disulfide bridges to introduce covalent links into the prefusion F protein trimer of measles virus....
Functional Interaction between Paramyxovirus Fusion and Attachment Proteins*S⃞
Lee, Jin K., Prussia, Andrew, Paal, Tanja, White, Laura K., Snyder, James P., Plemper, Richard K.
Paramyxovirinae envelope glycoproteins constitute a premier model to dissect how specific and dynamic interactions in multisubunit membrane protein complexes can control deep-seated conformational...