Scientific Commons: Richard L. Chang

Tumorigenicity of racemic and optically pure bay region diol epoxides and other derivatives of the nitrogen heterocycle dibenz[a,h]acridine on mouse skin (2001)

Kumar, Subodh, Chang, Richard L., Wood, Alexander W., Xie, Jian Guo, Huang, Mou Tuan, Cui, Xiao Xing, ...

CD-1 female mice were initiated with a single topical application of 500 nmol dibenz[a,h]acridine (DB[a,h]Acr), its racemic trans-1,2-, 3,4-, 8,9- and 10,11-dihydrodiols, racemic...

Tumorigenicity of four optically active bay-region 3,4-diol 1,2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice (2000)

Chang, Richard L., Wood, Alexander W., Kumar, Subodh, Lehr, Roland E., Shirai, Naohiro, Jerina, Donald M., ...

The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1,2-epoxides as well as other bay-region epoxides...

Characterization of the mutational profile of (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells (1999)

Schiltz, Maria, Cui, Xiao Xing, Lu, Yao-Ping, Yagi, Haruhiko, Jerina, Donald M., Zdzienicka, Malgorzata Z., ...

Earlier studies have shown that the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-BPDE] at the hypoxanthine...

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene (1999)

Wei, Shu-Jing Caroline, Chang, Richard L., Merkler, Kathleen A., Gwynne, Mark, Cui, Xiao Xing, Murthy, Bindu, ...

Female CD-1 mice were treated topically with a low (25–50 nmol) or high (800 nmol) dose of benzo[a]pyrene (BP) or acetone vehicle, followed by 5 nmol 12-O-tetradecanoylphorbol 13-acetate...

Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotion (1995)

Huang, Mou-Tuan, Ma, Wei, Lu, Yao-Ping, Chang, Richard L., Fisher, Carolyn, Manchand, Percy S., ...

Commercial grade curcumin (∼77% curcumin, 17% demethoxycurcumin and 3% bisdemethoxycurcumin) is widely used as a yellow coloring agent and spice in foods. In the present study...

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis (1994)

Lu, Yao-ping, Chang, Richard L., Lou, You-rong, Huang, Mou-Tuan, Newmark, Harold L., Reuhl, Kenneth R., ...

Expression of c-jun was observed in normally Proliferating JB6 cells but not in confluent cells. Reduction of the serum concentration from 5% to 2% in the cell culture medium caused JB6 cells to...

Bacterial and mammalian cell mutagenicity of four optically active bay-region 10,11-diol-8,9-epoxides of the nitrogen heterocycle dibenz (a,h) acridine (1993)

Chang, Richard L., Battista, Silvia, Wong, Ching-Quo, Kumar, Subodh, Kole, Panna L., Sikka, Harish C., ...

The mutagenk activities of the enantiomers of the diastereo-meric pair of bay-region 10, 11-diol-8, 9-epoxides of dibenz-[a,h]acridine (DB[a,h]ACR) were evaluated in histidine-dependent strains of...

Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3, 3'-di-O-methylellagic acid in mice (1986)

Smart, Robert C., Huang, Mou-Tuan, Chang, Richard L., Sayer, Jane M., Jerina, Donald M., Conney, Allan H.

The effect of ellagic acid and some of its more lipophilk derivatives on the mutagenicity of (� )-7β, 8α-di-hydroxy-9α 10α-epoxy-7, 8, 910-etrahydrobenz[a]pyrene was examined in Salmonella...

Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice (1986)

Smart, Robert C., Huang, Mou-Tuan, Chang, Richard L., Sayer, Jane M., Jerina, Donald M., Wood, Alexander W., ...

The effect of ellagic acid and its more lipophilic derivative, 3-O-decylellagic acid, on the amount of DNA-bound adducts in the epidermis or lung of CD-I mice treated with [3H]benzo-[a]pyrene...

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives (1985)

Huang, Mou-Tuan, Chang, Richard L., Wood, Alexander W., Newmark, Harold L., Sayer, Jane M., Yagi, Haruhiko, ...

Tannic acid and several hydroxylated anthraquinone and cinnamic acid derivatives inhibited the mutagenic activity of (±)-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P...

Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and ({+/-})-7{beta}, 8{alpha}-dihydroxy-9{alpha}, 10{alpha}-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse (1985)

Chang, Richard L., Huang, Mou-Tuan, Wood, Alexander W., Wong, Ching-Quo, Newmark, Harold L., Yagi, Haruhiko, ...

Ellagic acid, quercetin and robinetin were tested for their ability to antagonize the tumor-initiating activity of benzo[a]pyrene (B[a]P) and (±)-7β, 8α-dihydroxy-9α,...

Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: Preliminary studies on therapeutic efficacy and toxicity

Han, Zheng Tao, Zhu, Xiao Xiu, Yang, Ru Yu, Sun, Jun Zhong, Tian, Guo Fang, Liu, Xin Jian, ...

Studies by several investigators have shown that 12–0-tetradecanoylphorbol-13-acetate (TPA) is an extraordinarily potent stimulator of differentiation of cultured human promyelocytic leukemia cells...

12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs

Han, Zheng Tao, Tong, Yun Ke, He, Lin Min, Zhang, Yang, Sun, Jun Zhong, Wang, Tian Yi, ...

Fifty-two patients with solid tumors had depressed white blood cell and neutrophil counts because of prior treatment with cytotoxic cancer chemotherapeutic drugs. These patients were given one or...

Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid

Wood, Alexander W., Huang, Mou-Tuan, Chang, Richard L., Newmark, Harold L., Lehr, Roland E., Yagi, Haruhiko, ...

Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (±)-7β,8α-dihydroxy-9α,...

Mutagenicity and cytotoxicity of benz[a]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides

Wood, Alexander W., Chang, Richard L., Levin, Wayne, Lehr, Roland E., Schaefer-Ridder, Maria, Karle, Jean M., ...

Three diastereomeric pairs of diol epoxides, two tetrahydro-epoxides, and the K-region oxide of the polycyclic aromatic hydrocarbon benz[a]anthracene were evaluated for mutagenic activity in strain...