Richard L. Ferrero

Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli (2009)

Badea, Luminita, Beatson, Scott A, Kaparakis, Maria, Ferrero, Richard L, Hartland, Elizabeth L

Abstract Background Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) pathogen that possesses a type III secretion system (T3SS) encoded within the locus of enterocyte...

Exposure to Metronidazole In Vivo Readily Induces Resistance in Helicobacter pylori and Reduces the Efficacy of Eradication Therapy in Mice

Jenks, Peter J., Labigne, Agnes, Ferrero, Richard L.

The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure...

Evaluation of Nitrofurantoin Combination Therapy of Metronidazole-Sensitive and -Resistant Helicobacter pylori Infections in Mice

Jenks, Peter J., Ferrero, Richard L., Tankovic, Jacques, Thiberge, Jean-Michel, Labigne, Agnès

The main objectives of this study were to determine whether the nitroreductase enzyme encoded by the rdxA gene of Helicobacter pylori was responsible for reductive activation of nitrofurantoin and...

Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice

Radcliff, Fiona J., Ferrero, Richard L.

The effect of low-dose antigen exposure on the development of immunity to Helicobacter pylori infection was studied in outbred mice. Animals that were primed with a subinfectious number of H. pylori...

Helicobacter pylori rocF Is Required for Arginase Activity and Acid Protection In Vitro but Is Not Essential for Colonization of Mice or for Urease Activity

McGee, David J., Radcliff, Fiona J., Mendz, George L., Ferrero, Richard L., Mobley, Harry L. T.

Arginase of the Helicobacter pylori urea cycle hydrolyzes l-arginine to l-ornithine and urea. H. pylori urease hydrolyzes urea to carbon dioxide and ammonium, which neutralizes acid. Both enzymes are...

Immune Responses of Specific-Pathogen-Free Mice to Chronic Helicobacter pylori (Strain SS1) Infection

Ferrero, Richard L., Thiberge, Jean-Michel, Huerre, Michel, Labigne, Agnès

A model permitting the establishment of persistent Helicobacter pylori infection in mice was recently described. To evaluate murine immune responses to H. pylori infection, specific-pathogen-free...

Exposure to Metronidazole In Vivo Readily Induces Resistance in Helicobacter pylori and Reduces the Efficacy of Eradication Therapy in Mice

Jenks, Peter J., Labigne, Agnes, Ferrero, Richard L.

The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure...

Evaluation of Nitrofurantoin Combination Therapy of Metronidazole-Sensitive and -Resistant Helicobacter pylori Infections in Mice

Jenks, Peter J., Ferrero, Richard L., Tankovic, Jacques, Thiberge, Jean-Michel, Labigne, Agnès

The main objectives of this study were to determine whether the nitroreductase enzyme encoded by the rdxA gene of Helicobacter pylori was responsible for reductive activation of nitrofurantoin and...

Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice

Radcliff, Fiona J., Ferrero, Richard L.

The effect of low-dose antigen exposure on the development of immunity to Helicobacter pylori infection was studied in outbred mice. Animals that were primed with a subinfectious number of H. pylori...

Helicobacter pylori rocF Is Required for Arginase Activity and Acid Protection In Vitro but Is Not Essential for Colonization of Mice or for Urease Activity

McGee, David J., Radcliff, Fiona J., Mendz, George L., Ferrero, Richard L., Mobley, Harry L. T.

Arginase of the Helicobacter pylori urea cycle hydrolyzes l-arginine to l-ornithine and urea. H. pylori urease hydrolyzes urea to carbon dioxide and ammonium, which neutralizes acid. Both enzymes are...

Immune Responses of Specific-Pathogen-Free Mice to Chronic Helicobacter pylori (Strain SS1) Infection

Ferrero, Richard L., Thiberge, Jean-Michel, Huerre, Michel, Labigne, Agnès

A model permitting the establishment of persistent Helicobacter pylori infection in mice was recently described. To evaluate murine immune responses to H. pylori infection, specific-pathogen-free...

NF-κB Activation during Acute Helicobacter pylori Infection in Mice▿

Ferrero, Richard L., Avé, Patrick, Ndiaye, Delphine, Bambou, Jean-Christophe, Huerre, Michel R., Philpott, Dana J., ...

Nuclear factor κB (NF-κB) plays a key regulatory role in host cell responses to Helicobacter pylori infection in humans. Although mice are routinely used as a model to study H. pylori pathogenesis,...

A Commensal Helicobacter sp. of the Rodent Intestinal Flora Activates TLR2 and NOD1 Responses in Epithelial Cells

Chaouche-Drider, Nadia, Kaparakis, Maria, Karrar, Abdulgader, Fernandez, Maria-Isabel, Carneiro, Letitia A. M., Viala, Jérôme, ...

Helicobacter spp. represent a proportionately small but significant component of the normal intestinal microflora of animal hosts. Several of these intestinal Helicobacter spp. are known to induce...

The β1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells*S⃞

Snider, Jared L., Allison, Cody, Bellaire, Bryan H., Ferrero, Richard L., Cardelli, James A.

The Helicobacter pylori CagA protein is translocated into gastric epithelial cells through a type IV secretion system (TFSS), and published studies suggest CagA is critical for H. pylori-associated...