Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, ...
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in...
Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. (2007)
Smith, Ruben, Klein, Pontus, Koc-Schmitz, Yeliz, Waldvogel, Henry J, Faull, Richard L M, Brundin, Patrik, ...
Abstract is not available
Striosomes and mood dysfunction in Huntington's disease (2007)
Tippett, Lynette J., Waldvogel, Henry J., Thomas, Sally J., Hogg, Virginia M., Roon-Mom, Willeke Van, Synek, Beth J., ...
Variable phenotype is common in neurological disorders with single-gene inheritance patterns. In Huntington's disease, mood and cognitive symptoms are variably co-expressed with motor symptoms. There...
Regional and cellular gene expression changes in human Huntington's disease brain (2006)
Hodges, Angela Kaye, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes , Gareth, ...
Regional and cellular gene expression changes in human Huntington's disease brain (2006)
Hodges, Angela Kaye, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes , Gareth, ...
Cholinergic neuronal defect without cell loss in Huntington's disease. (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Abstract is not available
Cholinergic neuronal defect without cell loss in Huntington's disease (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...
Regional and cellular gene expression changes in human Huntington's disease brain (2006)
Hodges, Angela, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes, Gareth, ...
Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been...
Striosomes and mood dysfunction in Huntington's disease (2006)
Tippett, Lynette J., Waldvogel, Henry J., Thomas, Sally J., Hogg, Virginia M., Synek, Beth J., ...
Variable phenotype is common in neurological disorders with single-gene inheritance patterns. In Huntington's disease, mood and cognitive symptoms are variably co-expressed with motor symptoms. There...
Striosomes and mood dysfunction in Huntington's disease (2006)
Tippett, Lynette J., Waldvogel, Henry J., Thomas, Sally J., Hogg, Virginia M., Synek, Beth J., ...
Variable phenotype is common in neurological disorders with single-gene inheritance patterns. In Huntington's disease, mood and cognitive symptoms are variably co-expressed with motor symptoms. There...
Striosomes and mood dysfunction in Huntington's disease (2006)
Tippett, Lynette J., Waldvogel, Henry J., Thomas, Sally J., Hogg, Virginia M., Synek, Beth J., ...
Variable phenotype is common in neurological disorders with single-gene inheritance patterns. In Huntington's disease, mood and cognitive symptoms are variably co-expressed with motor symptoms. There...
Regional and cellular gene expression changes in human Huntington's disease brain (2006)
Hodges, Angela, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes, Gareth, ...
Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been...
Cholinergic neuronal defect without cell loss in Huntington's disease (2006)
Smith, Ruben, Chung, Hinfan, Rundquist, Sara, Colgan, Lesley, Englund, Elisabet, ...
Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG-repeat expansion in the huntingtin (IT15) gene. The striatum is one of the regions most affected by neurodegeneration,...
Molecular investigation of TBP allele length: a SCA17 cellular model and population study (2003)
Reid, Suzanne J., Rees, Mark I., Jones, A. Lesley, MacDonald, Marcy E., Sutherland, Greg Trevor, ...
Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). The normal repeat range...
Molecular investigation of TBP allele length: a SCA17 cellular model and population study (2003)
Reid, Suzanne J., Rees, Mark I., Jones, A. Lesley, MacDonald, Marcy E., Sutherland, Greg Trevor, ...
Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). The normal repeat range...
Molecular investigation of TBP allele length: a SCA17 cellular model and population study (2003)
Reid, Suzanne J., Rees, Mark I., Jones, A. Lesley, MacDonald, Marcy E., Sutherland, Greg Trevor, ...
Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). The normal repeat range...
Molecular investigation of TBP allele length: a SCA17 cellular model and population study (2003)
Reid, Suzanne J., Rees, Mark I., Jones, A. Lesley, MacDonald, Marcy E., Sutherland, Greg Trevor, ...
Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). The normal repeat range...
Mimmack, Michael L., Ryan, Margaret, Baba, Hajime, Navarro-Ruiz, Juani, Iritani, Shuji, Faull, Richard L. M., ...
We screened a custom-made candidate gene cDNA array comprising 300 genes. Genes chosen have either been implicated in schizophrenia, make conceptual sense in the light of the current understanding of...
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, Maurice A., Penney, Ellen B., Pearson, Andree G., Butterworth, Niqi J., Dragunow, Michael, ...
Neurogenesis has recently been observed in the adult human brain, suggesting the possibility of endogenous neural repair. However, the augmentation of neurogenesis in the adult human brain in...
Mimmack, Michael L., Ryan, Margaret, Baba, Hajime, Navarro-Ruiz, Juani, Iritani, Shuji, Faull, Richard L. M., ...
We screened a custom-made candidate gene cDNA array comprising 300 genes. Genes chosen have either been implicated in schizophrenia, make conceptual sense in the light of the current understanding of...
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, Maurice A., Penney, Ellen B., Pearson, Andree G., Butterworth, Niqi J., Dragunow, Michael, ...
Neurogenesis has recently been observed in the adult human brain, suggesting the possibility of endogenous neural repair. However, the augmentation of neurogenesis in the adult human brain in...
DNA instability in postmitotic neurons
Gonitel, Roman, Moffitt, Hilary, Sathasivam, Kirupa, Woodman, Ben, Detloff, Peter J., Faull, Richard L. M., ...
Huntington's disease (HD) is caused by a CAG repeat expansion that is unstable upon germ-line transmission and exhibits mosaicism in somatic tissues. We show that region-specific CAG repeat mosaicism...
Baer, Kristin, Waldvogel, Henry J., Faull, Richard L. M., Rees, Mark I.
Inhibitory neurotransmitter receptors for glycine (GlyR) are heteropentameric chloride ion channels that are comprised of four functional subunits, alpha1–3 and beta and that facilitate...