Sangeetha Somayajula, Richard M. Leahy
We propose a mutual information based prior for incorporating information from co-registered anatomical images into PET image reconstruction. The prior uses mutual information between feature vectors...
MULTI-MODALITY TOMOGRAPHIC IMAGE RECONSTRUCTION USING MESH MODELING 1 (2008)
Jovan G. Brankov, Yongyi Yang, Richard M. Leahy, Miles N. Wernick
In this paper we investigate a mesh-modeling approach for multi-modality image reconstruction. In the proposed approach a mesh model uses information obtained from an anatomical MR image to aid in...
A. Joshi, David W. Shattuck, Paul M. Thompson, Richard M. Leahy
We present a cortical surface registration method that simultaneously aligns sulcal landmarks and parameterizes two cortical surfaces. The approach is based on coregistration of cortical surface...
Modeling versus Accuracy in EEG and MEG Data (2008)
John C. Mosher, Richard M. Leahy, Ming-xiong Huang, Michael E. Spencer, Mosher J. C
this paper that highlight some of the problems of forward modeling, then discuss the impacts these results have on the inverse problem. We begin by assuming a perfect head model, that of the sphere,...
ENSEMBLE DE-NOISING OF SPATIO-TEMPORAL EEG AND MEG DATA (2007)
Stephan Wei, Richard M. Leahy, John C. Mosher, Robert W. Stewart
We present a de-noising method for spatio-temporal EEG / MEG data that incorporates prestimulus and spatial information to estimate the noise and signal energies and select a robust denoising...
Ensemble De-Noising Of Spatio-Temporal EEG And MEG Data (2007)
Stephan Weiss, Richard M. Leahy, John C. Mosher, Robert W. Stewart
We present a de-noising method for spatio-temporal EEG/ MEG data that incorporates prestimulus and spatial information to estimate the noise and signal energies and select a robust denoising...
Fully 3D Bayesian Image Reconstruction for the ECAT EXACT HR+ (2007)
Jinyi Qi, Richard M. Leahy, Chinghan Hsu, Thomas H. Farquhar, Student Member, Student Member, ...
A fully 3D Bayesian method is described for high resolution reconstruction of images from the Siemens/CTI ECAT EXACT HR+ whole body positron emission tomography (PET) scanner. To maximize resolution...
Fast computation of the covariance of MAP reconstructions of PET images (2007)
Pet Images, Jinyi Qi, Richard M. Leahy
We develop an approximate theoretical formula for fast computation of the covariance of PET images reconstructed using maximum a posteriori (MAP) estimation. The results assume a Poisson likelihood...
Fully 3D Bayesian Image Reconstruction for the ECAT EXACT HR+ (2007)
Jinyi Qi, Richard M. Leahy, Chinghan Hsu, Thomas H. Farquhar, Student Member, Student Member, ...
A fully 3D Bayesian method is described for high resolution reconstruction of images from the Siemens/CTI ECAT EXACT HR+ whole body positron emission tomography (PET) scanner. To maximize resolution...
Jinyi Qi, Simon R. Cherry, Arion Chatziioannou, Richard M. Leahy, Richard M. Leahy
x Corresponding author:
Fennema-Notestine, Christine, Ozyurt, I Burak, Clark, Camellia P, Morris, Shaunna, Bischoff-Grethe, Amanda, Bondi, Mark W, ...
Performance of automated methods to isolate brain from nonbrain tissues in magnetic resonance (MR) structural images may be influenced by MR signal inhomogeneities, type of MR image set, regional...
Cortical surface parameterization by p-harmonic energy minimization (2004)
Anand A. Joshi, David W. Shattuck, Paul M. Thompson, Richard M. Leahy
Cortical surface parameterization has several applications in visualization and analysis of the brain surface. Here we propose a scheme for parameterizing the surface of the cerebral cortex. The...
Statistical Surface-Based Morphometry Using A Non-Parametric Approach (2004)
Dimitrios Pantazis, Richard M. Leahy, Thomas E. Nichols, Martin Styner
We present a novel method of statistical surface-based morphometry based on the use of non-parametric permutation tests. In order to evaluate morphological differences of brain structures, we compare...
Temporally Invariant Uniform Spatial Resolution (2003)
We investigate methods for obtaining uniform spatial resolution over the entire scan duration for penalized ML dynamic PET image reconstructions. We approximate the true continuous time...
Statistical Analysis of Multiplex Brain Gene Expression Images (2002)
Ossadtchi, Alex, Khan, Arshad H., Leahy, Richard M., Smith, Desmond J., Cherry, Simon R., Nichols, Thomas E., ...
Analysis of variance (ANOVA) was employed to investigate 9,000 gene expression patterns from brains of both normal mice and mice with a pharmacological model of Parkinson's disease (PD). The data set...
Spatiotemporal reconstruction of list-mode PET data (2002)
Thomas E. Nichols, Jinyi Qi, Evren Asma, Student Member, Richard M. Leahy, Senior Member
Abstract—We describe a method for computing a continuous time estimate of tracer density using list-mode positron emission tomography data. The rate function in each voxel is modeled as an...
Brainsuite: An automated cortical surface identification tool (2002)
David W. Shattuck, Richard M. Leahy
We describe a new magnetic resonance (MR) image analysis tool that produces cortical surface representations with spherical topology from MR images of the human brain. The tool provides a sequence of...
Brown, Vanessa M., Ossadtchi, Alex, Khan, Arshad H., Yee, Simon, Lacan, Goran, Melega, William P., ...
High-Throughput Imaging of Brain Gene Expression (2002)
Brown, Vanessa M., Ossadtchi, Alex, Khan, Arshad H., Cherry, Simon R., Leahy, Richard M., Smith, Desmond J.
Brown, Vanessa M., Ossadtchi, Alex, Khan, Arshad H., Yee, Simon, Lacan, Goran, Melega, William P., ...
Magnetic resonance image tissue classification using a partial volume model (2001)
David W. Shattuck, Stephanie R. S, Kirt A. Schaper, David A. Rottenberg, Richard M. Leahy
We describe a sequence of low-level operations to isolate and classify brain tissue within T1-weighted magnetic resonance images (MRI). Our method first removes nonbrain tissue using a combination of...
Statistical Approaches in Quantitative Positron Emission Tomography (1999)
Jinyi Qi, Richard M. Leahy, Richard M. Leahy
Positron emission tomography is a medical imaging modality for producing 3D images of the spatial distribution of biochemical tracers within the human body. The images are reconstructed from data...
We examine the spatial resolution and variance properties of PET images reconstructed using maximum a posteriori (MAP) or penalized-likelihood methods. Resolution is characterized by the contrast...
High resolution 3D Bayesian image reconstruction for microPET (1998)
Jinyi Qi, Richard M Leahy, Simon R Cherry, Arion Chatziioannou
Abstract. A Bayesian method is described for reconstruction of high-resolution 3D images from the microPET small-animal scanner. Resolution recovery is achieved by explicitly modelling the depth...
An Ensemble De-Noising Method for Spatio-Temporal EEG/MEG Data (1998)
Stephan Weiss, Richard M. Leahy, John C. Mosher, Robert W. Stewart
. EEG/MEG are important tools for non-invasive medical diagnosis and basic studies of the brain and its functioning, but often applications are limited due to a very low SNR in the data. Here, we...
A study of dipole localization accuracy for MEG and EEG using a human skull phantom (1998)
R. M. Leahy, J. C. Mosher, M. E. Spencer, M. X. Huang, J. D. Lewine, Richard M. Leahy, ...
Objective: to investigate the accuracy of forward and inverse techniques for EEG and MEG dipole localization. Design and Methods: a human skull phantom was constructed with brain, skull and scalp...
Fully 3D Bayesian Image Reconstruction for the ECAT EXACT HR+ (1998)
Jinyi Qi Student, Jinyi Qi, Richard M. Leahy, Chinghan Hsu, Thomas H. Farquhar, Student Member, ...
A fully 3D Bayesian method is described for high resolution reconstruction of images from the Siemens/CTI ECAT EXACT HR+ whole body positron emission tomography (PET) scanner. To maximize resolution...
Recursive MUSIC: A Framework for EEG and MEG Source Localization (1998)
For Eeg, Meg Source Localization, John C. Mosher, John C. Mosher, Richard M. Leahy, Richard M. Leahy
This technical report has been revised and submitted for review and possible publication in a journal. Because changes may be made before publication, this document is made available with the...
Matrix Kernels for the Forward Problem in EEG and MEG (1997)
In Eeg, Richard M. Leahy, Paul S. Lewis, John C. Mosher, John C. Mosher
This technical report has been submitted for review and possible publication in a journal. Because changes may be made before publication, this document is made available with the understanding that...
EEG and MEG Source Localization using Recursively Applied (RAP) MUSIC (1996)
John C. Mosher, Richard M. Leahy
The multiple signal characterization (MUSIC) algorithm locates multiple asynchronous dipolar sources from electroencephalography (EEG) and magnetoencephalography (MEG) data. A signal subspace is...
Erkan U. Mumcuoglu, Richard M. Leahy, Simon R. Cherry, Ed Hoffman
Accurate modeling of the data formation and detection process in PET is essential for optimizing resolution. Here we develop a model in which the following factors are explicitly included: depth...
Multiplex Three-Dimensional Brain Gene Expression Mapping in a Mouse Model of Parkinson's Disease
Brown, Vanessa M., Ossadtchi, Alex, Khan, Arshad H., Yee, Simon, Lacan, Goran, Melega, William P., ...
To facilitate high-throughput 3D imaging of brain gene expression, a new method called voxelation has been developed. Spatially registered voxels (cubes) are analyzed, resulting in multiple...
Multiplex Three-Dimensional Brain Gene Expression Mapping in a Mouse Model of Parkinson's Disease
Brown, Vanessa M., Ossadtchi, Alex, Khan, Arshad H., Yee, Simon, Lacan, Goran, Melega, William P., ...
To facilitate high-throughput 3D imaging of brain gene expression, a new method called voxelation has been developed. Spatially registered voxels (cubes) are analyzed, resulting in multiple...
Coherent neural representation of hand speed in humans revealed by MEG imaging
Jerbi, Karim, Lachaux, Jean-Philippe, N′Diaye, Karim, Pantazis, Dimitrios, Leahy, Richard M., Garnero, Line, ...
The spiking activity of single neurons in the primate motor cortex is correlated with various limb movement parameters, including velocity. Recent findings obtained using local field potentials...
Ahn, Sangtae, Wang, Richard T., Park, Christopher C., Lin, Andy, Leahy, Richard M., Lange, Kenneth, ...
Meiotic mapping of quantitative trait loci regulating expression (eQTLs) has allowed the construction of gene networks. However, the limited mapping resolution of these studies has meant that...