APPENDIX Commissioned Papers References COMMISSIONED PAPERS (2008)
W. M. Beeson, Kenny S Crump, Virgil W. Hays, J. C. Headley, Richard P. Novick
Chapters III and IV, which summarize the evidence on the benefits ancl risks of the use of drugs in livestock feeding, were based on reviews commissioned by the office of Technology
Ruzhong Jin, Xiaomei Zhou, Richard P. Novick
Staphylococcus aureus plasmid pT181 replicates via a rolling circle mechanism. The synthesis of the pT181 initiator protein (RepC) is regulated by antisense RNAs, and RepC is inactivated after usage...
Yao, Jun, Zhong, Jin, Fang, Yuan, Geisinger, Edward, Novick, Richard P., Lambowitz, Alan M.
We show that a targetron based on the Lactococcus lactis Ll.LtrB group II intron can be used for efficient chromosomal gene disruption in the human pathogen Staphylococcus aureus. Targetrons...
Yao, Jun, Zhong, Jin, Fang, Yuan, Geisinger, Edward, Novick, Richard P., Lambowitz, Alan M.
We show that a targetron based on the Lactococcus lactis Ll.LtrB group II intron can be used for efficient chromosomal gene disruption in the human pathogen Staphylococcus aureus. Targetrons...
Yao, Jun, Zhong, Jin, Fang, Yuan, Geisinger, Edward, Novick, Richard P., Lambowitz, Alan M.
We show that a targetron based on the Lactococcus lactis Ll.LtrB group II intron can be used for efficient chromosomal gene disruption in the human pathogen Staphylococcus aureus. Targetrons...
Wirth,Thierry, Wang,Xiaoyan, Linz,Bodo, Novick,Richard P., Lum,J. Koji, Blaser,Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Nucleotide sequence: the {beta}-hemolysin gene of Staphylococcus aureus (1989)
Projan, Steven J., Kornblum, John, Kreiswirth, Barry, Moghazeh, Soraya L., Eisner, William, Novick, Richard P.
Nucleotide sequence of pS194, a streptomycin-resistance plasmid from Staphylococcus aureus (1988)
Projan, Steven J., Moghazeh, Soraya, Novick, Richard P.
pS194 is a naturally occurring Staphylococcus aureus plasmid encoding streptomycin resistance. The plasmid has a copy number of about 25 per cell, and belongs to the inc5 incompatibility group. The...
Intermediates in plasmid pT181 DNA replication (1988)
Majumder, Sadhan, Novick, Richard P.
Staphylococcus aureus plasmid pT181 is thought to replicate via an asymmetric rolling-circle mechanism. By studying pulse labeled replicative intermediates, here we report that pT181 replication...
Levy, Stuart B, Novick, Richard P
Incluye bibliografía e indice
MLS-resistance determinants in Staphylococcus aureus and their molecular evolution (1985)
Novick, Richard P., Murphy, Ellen
This paper describes the genetic phenomenology of resistance to macrolide- lincosamide-streptogramin B antibiotics (MLSr) in Staphylococcus aureus and attempts to place this phenomenology in a broad...
Penicillinase Plasmid DNA from Staphylococcus aureus (1969)
Rush, Mark G., Gordon, C. N., Novick, Richard P., Warner, Robert C.
A penicillinase plasmid from Staphylococcus aureus and three of its derivatives, all previously identified as extrachromosomal genetic elements, have been isolated in high yield as circular duplex...
Mayville, Patricia, Ji, Guangyong, Beavis, Ronald, Yang, Hongmei, Goger, Michael, Novick, Richard P., ...
The synthesis of virulence factors and other extracellular proteins responsible for pathogenicity in Staphylococcus aureus is under the control of the agr locus. A secreted agr-encoded peptide, AgrD,...
Lyon, Gholson J., Mayville, Patricia, Muir, Tom W., Novick, Richard P.
Two-component signaling systems involving receptor-histidine kinases are ubiquitous in bacteria and have been found in yeast and plants. These systems provide the major means by which bacteria...
Biochemical and Biological Properties of Staphylococcal Enterotoxin K
Orwin, Paul M., Leung, Donald Y. M., Donahue, Heather L., Novick, Richard P., Schlievert, Patrick M.
Staphylococcus aureus is an important human pathogen which is implicated in a wide variety of diseases. Major determinants of the virulence of this organism include extracellular virulence factors....
Herbert, Silvia, Barry, Peter, Novick, Richard P.
It has long been known that certain antibiotics, at subinhibitory concentrations, differentially inhibit the synthesis of α-hemolysin and other staphylococcal virulence factors. In this report, we...
Glycerol Monolaurate Inhibits Induction of Vancomycin Resistance in Enterococcus faecalis
Ruzin, Alexey, Novick, Richard P.
Glycerol monolaurate (GML) is a surfactant that has been found to inhibit the post-exponential phase activation of virulence factor production and the induction of β-lactamase in Staphylococcus...
Ruzin, Alexey, Novick, Richard P.
Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal...
Global repression of exotoxin synthesis by staphylococcal superantigens
Vojtov, Nikola, Ross, Hope F., Novick, Richard P.
Virulent Staphylococcus aureus strains typically produce and secrete large quantities of many extracellular proteins involved in pathogenesis. Such strains cause the classical staphylococcal...
Sakoulas, George, Eliopoulos, George M., Moellering, Robert C., Wennersten, Christine, Venkataraman, Lata, Novick, Richard P., ...
The majority of infections with glycopeptide intermediate-level resistant Staphylococcus aureus (GISA) originate in biomedical devices, suggesting a possible increased ability of these strains to...
Romero-Gallo, Judith, Pérez-Pérez, Guillermo I., Novick, Richard P., Kamath, Patrick, Norbu, Tsering, Blaser, Martin J.
Although Helicobacter pylori is a cosmopolitan colonizer of the human stomach, the responses among persons in remote populations from whom H. pylori was cultured have not been studied. We report on...
High Genetic Variability of the agr Locus in Staphylococcus Species
Dufour, Philippe, Jarraud, Sophie, Vandenesch, Francois, Greenland, Timothy, Novick, Richard P., Bes, Michele, ...
The agr quorum-sensing and signal transduction system was initially described in Staphylococcus aureus, where four distinct allelic variants have been sequenced. Western blotting suggests the...
PENICILLINASE PLASMID DNA FROM Staphylococcus aureus*
Rush, Mark G., Gordon, C. N., Novick, Richard P., Warner, Robert C.
A penicillinase plasmid from Staphylococcus aureus and three of its derivatives, all previously identified as extrachromosomal genetic elements, have been isolated in high yield as circular duplex...
Plasmid-Specific Transformation in Staphylococcus aureus
Lindberg, Martin, Novick, Richard P.
Transformation of Staphylococcus aureus cells with circular duplex deoxyribonucleic acid prepared from plasmid-carrying strains by alkali denaturation and selective renaturation or by dye-buoyant...
Naturally Occurring Penicillinase Plasmids in Staphylococcus aureus
Peyru, Graciela, Wexler, Laura Fooner, Novick, Richard P.
A series of plasmids harbored by naturally occurring penicillin-resistant strains of Staphylococcus aureus were surveyed with a view toward exploring the variability in plasmid-linked marker...
Genetic Studies on Plasmid-Linked Cadmium Resistance in Staphylococcus aureus
Smith, Katherine, Novick, Richard P.
The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI524, PI258, and PII147, of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis....
Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus
Novick, Richard P., Roth, Christine
The penicillinase plasmids, a series of extrachromosomal resistance factors in Staphylococcus aureus, were found to carry determinants of resistance to a series of inorganic ions as well as...
Novick, Richard P., Richmond, Mark H.
Novick, Richard P. (The Rockefeller Institute, New York, N.Y.), and Mark H. Richmond. Nature and interactions of the genetic elements governing penicillinase synthesis in Staphylococcus aureus. J....
Wirth, Thierry, Wang, Xiaoyan, Linz, Bodo, Novick, Richard P., Lum, J. Koji, Blaser, Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Novel Cassette-Based Shuttle Vector System for Gram-Positive Bacteria
Charpentier, Emmanuelle, Anton, Ana I., Barry, Peter, Alfonso, Berenice, Fang, Yuan, Novick, Richard P.
Our understanding of staphylococcal pathogenesis depends on reliable genetic tools for gene expression analysis and tracing of bacteria. Here, we have developed and evaluated a series of novel...
Wright, Jesse S., Lyon, Gholson J., George, Elizabeth A., Muir, Tom W., Novick, Richard P.
Two-component systems represent the most widely used signaling paradigm in living organisms. Encoding the prototypical two-component system in Gram-positive bacteria, the staphylococcal agr...
Effect of Mild Acid on Gene Expression in Staphylococcus aureus
Weinrick, Brian, Dunman, Paul M., McAleese, Fionnuala, Murphy, Ellen, Projan, Steven J., Fang, Yuan, ...
During staphylococcal growth in glucose-supplemented medium, the pH of a culture starting near neutrality typically decreases by about 2 units due to the fermentation of glucose. Many species can...
Transient interference with staphylococcal quorum sensing blocks abscess formation
Wright, Jesse S., Jin, Rhuzong, Novick, Richard P.
The staphylococcal virulon is controlled largely by the agr locus, a global accessory gene regulator that is autoinduced by a self-coded peptide (AIP) and is therefore a quorum sensor. The agr locus...
Ji, Guangyong, Pei, Wuhong, Zhang, Linsheng, Qiu, Rongde, Lin, Jianqun, Benito, Yvonne, ...
The agr system is a global regulator of accessory functions in staphylococci, including genes encoding exoproteins involved in virulence. The agr locus contains a two-component signal transduction...
The agr Radiation: an Early Event in the Evolution of Staphylococci†
Wright, Jesse S., Traber, Katrina E., Corrigan, Rebecca, Benson, Sarah A., Musser, James M., Novick, Richard P.
agr is a global regulatory system in the staphylococci, operating by a classical two-component signaling module and controlling the expression of most of the genes encoding extracellular virulence...
Sakoulas, George, Eliopoulos, George M., Fowler, Vance G., Moellering, Robert C., Novick, Richard P., Lucindo, Natalie, ...
Loss of agr function, vancomycin exposure, and abnormal autolysis have been linked with both development of the GISA phenotype and low-level resistance in vitro to thrombin-induced platelet...
Maiques, Elisa, Úbeda, Carles, Campoy, Susana, Salvador, Noelia, Lasa, Íñigo, Novick, Richard P., ...
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency...
Mayville, Patricia, Ji, Guangyong, Beavis, Ronald, Yang, Hongmei, Goger, Michael, Novick, Richard P., ...
The synthesis of virulence factors and other extracellular proteins responsible for pathogenicity in Staphylococcus aureus is under the control of the agr locus. A secreted agr-encoded peptide, AgrD,...
Lyon, Gholson J., Mayville, Patricia, Muir, Tom W., Novick, Richard P.
Two-component signaling systems involving receptor-histidine kinases are ubiquitous in bacteria and have been found in yeast and plants. These systems provide the major means by which bacteria...
Biochemical and Biological Properties of Staphylococcal Enterotoxin K
Orwin, Paul M., Leung, Donald Y. M., Donahue, Heather L., Novick, Richard P., Schlievert, Patrick M.
Staphylococcus aureus is an important human pathogen which is implicated in a wide variety of diseases. Major determinants of the virulence of this organism include extracellular virulence factors....
Herbert, Silvia, Barry, Peter, Novick, Richard P.
It has long been known that certain antibiotics, at subinhibitory concentrations, differentially inhibit the synthesis of α-hemolysin and other staphylococcal virulence factors. In this report, we...
Glycerol Monolaurate Inhibits Induction of Vancomycin Resistance in Enterococcus faecalis
Ruzin, Alexey, Novick, Richard P.
Glycerol monolaurate (GML) is a surfactant that has been found to inhibit the post-exponential phase activation of virulence factor production and the induction of β-lactamase in Staphylococcus...
Ruzin, Alexey, Novick, Richard P.
Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal...
Global repression of exotoxin synthesis by staphylococcal superantigens
Vojtov, Nikola, Ross, Hope F., Novick, Richard P.
Virulent Staphylococcus aureus strains typically produce and secrete large quantities of many extracellular proteins involved in pathogenesis. Such strains cause the classical staphylococcal...
Sakoulas, George, Eliopoulos, George M., Moellering, Robert C., Wennersten, Christine, Venkataraman, Lata, Novick, Richard P., ...
The majority of infections with glycopeptide intermediate-level resistant Staphylococcus aureus (GISA) originate in biomedical devices, suggesting a possible increased ability of these strains to...
Romero-Gallo, Judith, Pérez-Pérez, Guillermo I., Novick, Richard P., Kamath, Patrick, Norbu, Tsering, Blaser, Martin J.
Although Helicobacter pylori is a cosmopolitan colonizer of the human stomach, the responses among persons in remote populations from whom H. pylori was cultured have not been studied. We report on...
High Genetic Variability of the agr Locus in Staphylococcus Species
Dufour, Philippe, Jarraud, Sophie, Vandenesch, Francois, Greenland, Timothy, Novick, Richard P., Bes, Michele, ...
The agr quorum-sensing and signal transduction system was initially described in Staphylococcus aureus, where four distinct allelic variants have been sequenced. Western blotting suggests the...
PENICILLINASE PLASMID DNA FROM Staphylococcus aureus*
Rush, Mark G., Gordon, C. N., Novick, Richard P., Warner, Robert C.
A penicillinase plasmid from Staphylococcus aureus and three of its derivatives, all previously identified as extrachromosomal genetic elements, have been isolated in high yield as circular duplex...
Plasmid-Specific Transformation in Staphylococcus aureus
Lindberg, Martin, Novick, Richard P.
Transformation of Staphylococcus aureus cells with circular duplex deoxyribonucleic acid prepared from plasmid-carrying strains by alkali denaturation and selective renaturation or by dye-buoyant...
Naturally Occurring Penicillinase Plasmids in Staphylococcus aureus
Peyru, Graciela, Wexler, Laura Fooner, Novick, Richard P.
A series of plasmids harbored by naturally occurring penicillin-resistant strains of Staphylococcus aureus were surveyed with a view toward exploring the variability in plasmid-linked marker...
Genetic Studies on Plasmid-Linked Cadmium Resistance in Staphylococcus aureus
Smith, Katherine, Novick, Richard P.
The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI524, PI258, and PII147, of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis....
Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus
Novick, Richard P., Roth, Christine
The penicillinase plasmids, a series of extrachromosomal resistance factors in Staphylococcus aureus, were found to carry determinants of resistance to a series of inorganic ions as well as...
Novick, Richard P., Richmond, Mark H.
Novick, Richard P. (The Rockefeller Institute, New York, N.Y.), and Mark H. Richmond. Nature and interactions of the genetic elements governing penicillinase synthesis in Staphylococcus aureus. J....
Wirth, Thierry, Wang, Xiaoyan, Linz, Bodo, Novick, Richard P., Lum, J. Koji, Blaser, Martin, ...
The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative...
Novel Cassette-Based Shuttle Vector System for Gram-Positive Bacteria
Charpentier, Emmanuelle, Anton, Ana I., Barry, Peter, Alfonso, Berenice, Fang, Yuan, Novick, Richard P.
Our understanding of staphylococcal pathogenesis depends on reliable genetic tools for gene expression analysis and tracing of bacteria. Here, we have developed and evaluated a series of novel...
Wright, Jesse S., Lyon, Gholson J., George, Elizabeth A., Muir, Tom W., Novick, Richard P.
Two-component systems represent the most widely used signaling paradigm in living organisms. Encoding the prototypical two-component system in Gram-positive bacteria, the staphylococcal agr...
Effect of Mild Acid on Gene Expression in Staphylococcus aureus
Weinrick, Brian, Dunman, Paul M., McAleese, Fionnuala, Murphy, Ellen, Projan, Steven J., Fang, Yuan, ...
During staphylococcal growth in glucose-supplemented medium, the pH of a culture starting near neutrality typically decreases by about 2 units due to the fermentation of glucose. Many species can...
Transient interference with staphylococcal quorum sensing blocks abscess formation
Wright, Jesse S., Jin, Rhuzong, Novick, Richard P.
The staphylococcal virulon is controlled largely by the agr locus, a global accessory gene regulator that is autoinduced by a self-coded peptide (AIP) and is therefore a quorum sensor. The agr locus...
Ji, Guangyong, Pei, Wuhong, Zhang, Linsheng, Qiu, Rongde, Lin, Jianqun, Benito, Yvonne, ...
The agr system is a global regulator of accessory functions in staphylococci, including genes encoding exoproteins involved in virulence. The agr locus contains a two-component signal transduction...
Sakoulas, George, Eliopoulos, George M., Fowler, Vance G., Moellering, Robert C., Novick, Richard P., Lucindo, Natalie, ...
Loss of agr function, vancomycin exposure, and abnormal autolysis have been linked with both development of the GISA phenotype and low-level resistance in vitro to thrombin-induced platelet...
The agr Radiation: an Early Event in the Evolution of Staphylococci†
Wright, Jesse S., Traber, Katrina E., Corrigan, Rebecca, Benson, Sarah A., Musser, James M., Novick, Richard P.
agr is a global regulatory system in the staphylococci, operating by a classical two-component signaling module and controlling the expression of most of the genes encoding extracellular virulence...
Maiques, Elisa, Úbeda, Carles, Campoy, Susana, Salvador, Noelia, Lasa, Íñigo, Novick, Richard P., ...
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency...
Yao, Jun, Zhong, Jin, Fang, Yuan, Geisinger, Edward, Novick, Richard P., Lambowitz, Alan M.
We show that a targetron based on the Lactococcus lactis Ll.LtrB group II intron can be used for efficient chromosomal gene disruption in the human pathogen Staphylococcus aureus. Targetrons...
Role of Staphylococcal Phage and SaPI Integrase in Intra- and Interspecies SaPI Transfer▿
Maiques, Elisa, Úbeda, Carles, Tormo, María Ángeles, Ferrer, María Desamparados, Lasa, Íñigo, Novick, Richard P., ...
SaPIbov2 is a member of the SaPI family of staphylococcal pathogenicity islands and is very closely related to SaPIbov1. Typically, certain temperate phages can induce excision and replication of one...
Adhikari, Rajan P., Arvidson, Staffan, Novick, Richard P.
TraP is a triply phosphorylated staphylococcal protein that has been hypothesized to be the mediator of a second Staphylococcus aureus quorum-sensing system, “SQS1,” that controls expression of...
A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid
Úbeda, Carles, Barry, Peter, Penadés, José R., Novick, Richard P.
The SaPIs are 14- to 17-kb mobile pathogenicity islands in staphylococci that carry genes for superantigen toxins and other virulence factors and are responsible for the toxic shock syndrome and...
IN VIVO TRANSMISSION OF DRUG RESISTANCE FACTORS BETWEEN STRAINS OF STAPHYLOCOCCUS AUREUS
Novick, Richard P., Morse, Stephen I.
1. Multiply resistant strains of Staphylococcus aureus often harbor one or more extrachromosomal drug resistant factors as well as temperate prophages capable of mediating generalized transduction....
Tormo, María Ángeles, Ferrer, María Desamparados, Maiques, Elisa, Úbeda, Carles, Selva, Laura, Lasa, Íñigo, ...
Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently...
Geisinger, Edward, George, Elizabeth A., Muir, Tom W., Novick, Richard P.
Activation of the agr system, a major regulator of staphylococcal virulence, is initiated by the binding of a specific autoinducing peptide (AIP) to the extracellular domain of AgrC, a classical...
agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides
Geisinger, Edward, Muir, Tom W., Novick, Richard P.
Through the agr quorum-sensing system, staphylococci secrete unique autoinducing peptides (AIPs) and detect their concentration via the AgrC transmembrane receptor, coordinating local bacterial...
Killing niche competitors by remote-control bacteriophage induction
Selva, Laura, Viana, David, Regev-Yochay, Gili, Trzcinski, Krzysztof, Corpa, Juan Manuel, Lasa, íñigo, ...
A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of...