Rick Gussio

A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease (2007)

Burnett, James C., Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G., Ruthel, Gordon, Hermone, Ann R., ...

We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including...

Conformational Sampling of the Botulinum Neurotoxin Serotype a Light Chain: Implications for Inhibitor Binding (2005)

Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...

Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...

Novel Small Molecule Inhibitors of Botulinum Neurotoxin a Metalloprotease Activity (2003)

Burnett, James C., Schmidt, James J., Stafford, Robert G., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., ...

Botulinum neurotoxins (BoNTs) are among the most lethal biological substances to have been weaponized and are listed as biodefense category A agents. Currently, no small molecule (non-peptidic)...

Mol Pharmacol 61:720–728, 2002 Printed in U.S.A. Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors. (2001)

John S. Lazo, Kaoru Nemoto, Katharine E. Pestell, Kathleen Cooley, Eileen C. Southwick, Douglas A. Mitchell, ...

Small molecules provide powerful tools to interrogate biological pathways but many important pathway participants remain refractory to inhibitors. For example, Cdc25 dual-specificity phosphatases...

Conformational Sampling of the Botulinum Neurotoxin Serotype A Light Chain: Implications for Inhibitor Binding (1998)

Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...

Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...

An All-Atom Model of the Pore-Like Structure of Hexameric VP40 from Ebola: Structural Insights into the Monomer-Hexamer Transition (1998)

Nguyen, Tam L., Schoehn, Guy, Weissenhorn, Winfried, Hermone, Ann R., Burnett, James C., Panchal, Rekha G., ...

The matrix protein VP40 is an indispensable component of viral assembly and budding by the Ebola virus. VP40 is a monomer in solution, but can fold into hexameric and octameric states, two oligomeric...

Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade (1998)

Halverson, Kelly M., Panchal, Rekha G., Nguyen, Tam L., Gussio, Rick, Little, Stephen F., Misakian, Martin, ...

Bacillus anthracis secretes three proteins (protective antigen, PA; lethal factor, LF; and edema factor, EF) that are the basis for anthrax infection. We present electrophysiological measurements...

A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Giannakakou, Paraskevi, Gussio, Rick, Nogales, Eva, Downing, Kenneth H., Zaharevitz, Daniel, Bollbuck, Birgit, ...

The epothilones are naturally occurring antimitotic drugs that share with the taxanes a similar mechanism of action without apparent structural similarity. Although photoaffinity labeling and...

A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Giannakakou, Paraskevi, Gussio, Rick, Nogales, Eva, Downing, Kenneth H., Zaharevitz, Daniel, Bollbuck, Birgit, ...

The epothilones are naturally occurring antimitotic drugs that share with the taxanes a similar mechanism of action without apparent structural similarity. Although photoaffinity labeling and...

Sizing the Bacillus anthracis PA63 Channel with Nonelectrolyte Poly(Ethylene Glycols)

Nablo, Brian J., Halverson, Kelly M., Robertson, Joseph W. F., Nguyen, Tam L., Panchal, Rekha G., Gussio, Rick, ...

Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA63). Based on the ability of...