The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi (2009)
Minning, Todd A, Weatherly, D Brent, Atwood, James, Orlando, Ron, Tarleton, Rick L
Abstract Background Chronic chagasic cardiomyopathy is a debilitating and frequently fatal outcome of human infection with the protozoan parasite, Trypanosoma cruzi . Microarray analysis of gene...
Chromosome level assembly of the hybrid Trypanosoma cruzigenome (2009)
Weatherly, D Brent, Boehlke, Courtney, Tarleton, Rick L
Abstract Background In contrast to the essentially fully assembled genome sequences of the kinetoplastid pathogens Leishmania major and Trypanosoma brucei the assembly of the Trypanosoma cruzi genome...
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi (2009)
Xu, Dan, Pérez Brandán, Cecilia, Basombrío, Miguel, Tarleton, Rick L
Abstract Background Trypanosoma cruzi , a kinetoplastid protozoan parasite that causes Chagas disease, infects approximately 15 million people in Central and South America. In contrast to the...
Evaluación inmunológica del tratamiento con benznidazol en la enfermedad de Chagas crónica (2008)
Graciela L. Bertocchi, María G. Álvarez, Damián Pérez, Alejandro Armenti, Rodolfo J. Viotti, Bruno Lococo, ...
Para determinar el efecto del tratamiento con benznidazol sobre las células T de memoria específica para Trypanosoma cruzi, se seleccionaron 47 pacientes con tres reacciones serológicas positivas...
The Challenges of Chagas Disease— Grim Outlook or Glimmer of Hope? (2007)
Rick L. Tarleton, Richard Reithinger, Julio A. Urbina, Uriel Kitron, Ricardo E. Gürtler
Graham, Robert, Sharma, Mohit K, Ternan, Nigel G, Weatherly, D Brent, Tarleton, Rick L, McMullan, Geoff
Abstract Background The α-Proteobacteria are capable of interaction with eukaryotic cells, with some members, such as Ochrobactrum anthropi , capable of acting as human pathogens. O. anthropi has...
Diana L. Martin, D. Brent Weatherly, Susana A. Laucella, Melissa A. Cabinian, Matthew T. Crim, Susan Sullivan, ...
CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of...
Albareda, María Cecilia, Laucella, Susana Adriana, Alvarez, María Gabriela, Armenti, Alejandro Hector, Bertochi, Graciela, Tarleton, Rick L., ...
We present a cross-sectional analysis of the maturation and migratory properties of the memory CD8+ T cell compartment, in relation to the severity of heart disease in individuals with chronic...
TcruziDB: an integrated Trypanosoma cruzi genome resource (2004)
Luchtan, Michael, Warade, Chetna, Weatherly, D. Brent, Degrave, Wim M., Tarleton, Rick L., Kissinger, Jessica C.
TcruziDB (http://TcruziDB.org) is an integrated genome database for the parasitic organism Trypanosoma cruzi, the causative agent of Chagas’ disease. The database currently incorporates all...
Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL (1998)
Low, Hoi Pang, Santos, Maria A. M., Wizel, Benjamin, Tarleton, Rick L.
Amastigotes of Trypanosoma cruzi express surface proteins that, when released into the host cell cytoplasm, are processed and presented on the surface of infected cells in the context of MHC class I...
Low, Hoi Pang, Tarleton, Rick L.
Amastigote surface proteins of Trypanosoma cruzi are likely targets of both humoral and cell-mediated immune responses, however, few such molecules have been well studied. In this study, we have used...
Wizel, Benjamin, Garg, Nisha, Tarleton, Rick L.
DNA vaccination was evaluated with the experimental murine model of Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1...
Garg, Nisha, Tarleton, Rick L.
Immunity to Trypanosoma cruzi requires elicitation of humoral and cell-mediated immune responses to extracellular trypomastigotes and intracellular amastigotes. In this study, the effectiveness of...
TcruziDB: an integrated Trypanosoma cruzi genome resource
Luchtan, Michael, Warade, Chetna, Weatherly, D. Brent, Degrave, Wim M., Tarleton, Rick L., Kissinger, Jessica C.
TcruziDB (http://TcruziDB.org) is an integrated genome database for the parasitic organism Trypanosoma cruzi, the causative agent of Chagas’ disease. The database currently incorporates all...
Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice
Cummings, Kara L., Tarleton, Rick L.
Immune control of many intracellular pathogens, including Trypanosoma cruzi, is reported to be dependent on the production of nitric oxide. In this study, we show that mice deficient in inducible...
Martin, Diana L, Weatherly, D. Brent, Laucella, Susana A, Cabinian, Melissa A, Crim, Matthew T, Sullivan, Susan, ...
CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of...
Wizel, Benjamin, Garg, Nisha, Tarleton, Rick L.
DNA vaccination was evaluated with the experimental murine model of Trypanosoma cruzi infection as a means to induce antiparasite protective immunity, and the trypomastigote surface antigen 1...
Garg, Nisha, Tarleton, Rick L.
Immunity to Trypanosoma cruzi requires elicitation of humoral and cell-mediated immune responses to extracellular trypomastigotes and intracellular amastigotes. In this study, the effectiveness of...
TcruziDB: an integrated Trypanosoma cruzi genome resource
Luchtan, Michael, Warade, Chetna, Weatherly, D. Brent, Degrave, Wim M., Tarleton, Rick L., Kissinger, Jessica C.
TcruziDB (http://TcruziDB.org) is an integrated genome database for the parasitic organism Trypanosoma cruzi, the causative agent of Chagas’ disease. The database currently incorporates all...
Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice
Cummings, Kara L., Tarleton, Rick L.
Immune control of many intracellular pathogens, including Trypanosoma cruzi, is reported to be dependent on the production of nitric oxide. In this study, we show that mice deficient in inducible...
Martin, Diana L, Weatherly, D. Brent, Laucella, Susana A, Cabinian, Melissa A, Crim, Matthew T, Sullivan, Susan, ...
CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of...
The Challenges of Chagas Disease— Grim Outlook or Glimmer of Hope
Tarleton, Rick L, Reithinger, Richard, Urbina, Julio A, Kitron, Uriel, Gürtler, Ricardo E
The authors discuss the key challenges that undermine the control of Chagas disease and that must be urgently addressed to ensure long-term, sustainable control.
Graham, Robert Leslie James, Sharma, Mohit K, Ternan, Nigel G, Weatherly, D Brent, Tarleton, Rick L, McMullan, Geoff
A semi-quantitative gel-based analysis identifies distinct proteomic profiles associated with specific growth points for the nosocomial pathogen Ochrobactrum anthropi.
Alvarez, María G., Postan, Miriam, Weatherly, D. Brent, Albareda, María C., Sidney, John, Sette, Alessandro, ...
At present, 16–20 million people in Central and South America are infected with Trypanosoma cruzi, the causative agent of Chagas disease in humans. The primary clinical consequence of the infection...
High Throughput Selection of Effective Serodiagnostics for Trypanosoma cruzi infection
Cooley, Gretchen, Etheridge, R. Drew, Boehlke, Courtney, Bundy, Becky, Weatherly, D. Brent, Minning, Todd, ...
The diagnosis of Trypanosoma cruzi infection (the cause of human Chagas disease) is difficult because the symptoms of the infection are often absent or non-specific, and because the parasites...