Rico Laage

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis (2008)

Pitzer, Claudia, Krüger, Carola, Plaas, Christian, Kirsch, Friederike, Dittgen, Tanjew, Müller, Ralph, ...

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in progressive loss of motoneurons, motor weakness and death within 1–5 years after disease onset....

The hematopoietic factor GM-CSF (Granulocyte-macrophage colony-stimulating factor) promotes neuronal differentiation of adult neural stem cells in vitro (2007)

Krüger, Carola, Laage, Rico, Pitzer, Claudia, Schäbitz, Wolf-Rüdiger, Schneider, Armin

Abstract Background Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from...

An extended window of opportunity for G-CSF treatment in cerebral ischemia (2006)

Schneider, Armin, Wysocki, Rainer, Pitzer, Claudia, Krüger, Carola, Laage, Rico, Schwab, Stefan, ...

Abstract Background Granulocyte-colony stimulating factor (G-CSF) is known as a powerful regulator of white blood cell proliferation and differentiation in mammals. We, and others, have shown that...

BMC Biology BioMed Central (2006)

Armin Schneider, Rainer Wysocki, Claudia Pitzer, Carola Krüger, Rico Laage, Stefan Schwab, ...

Research article An extended window of opportunity for G-CSF treatment in cerebral ischemia

The N-terminal Domain of the t-SNARE Vam3p Coordinates Priming and Docking in Yeast Vacuole Fusion

Laage, Rico, Ungermann, Christian

Homotypic fusion of yeast vacuoles requires a regulated sequence of events. During priming, Sec18p disassembles cis-SNARE complexes. The HOPS complex, which is initially associated with the cis-SNARE...

Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion

Veit, Michael, Laage, Rico, Dietrich, Lars, Wang, Li, Ungermann, Christian

Activated fatty acids stimulate budding and fusion in several cell-free assays for vesicular transport. This stimulation is thought to be due to protein palmitoylation, but relevant substrates have...

The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis

Schneider, Armin, Krüger, Carola, Steigleder, Tobias, Weber, Daniela, Pitzer, Claudia, Laage, Rico, ...

G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation of neutrophilic granulocytes. Here, we show that G-CSF...

The N-terminal Domain of the t-SNARE Vam3p Coordinates Priming and Docking in Yeast Vacuole Fusion

Laage, Rico, Ungermann, Christian

Homotypic fusion of yeast vacuoles requires a regulated sequence of events. During priming, Sec18p disassembles cis-SNARE complexes. The HOPS complex, which is initially associated with the cis-SNARE...

Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion

Veit, Michael, Laage, Rico, Dietrich, Lars, Wang, Li, Ungermann, Christian

Activated fatty acids stimulate budding and fusion in several cell-free assays for vesicular transport. This stimulation is thought to be due to protein palmitoylation, but relevant substrates have...

The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis

Schneider, Armin, Krüger, Carola, Steigleder, Tobias, Weber, Daniela, Pitzer, Claudia, Laage, Rico, ...

G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation of neutrophilic granulocytes. Here, we show that G-CSF...

A cycle of Vam7p release from and PtdIns 3-P–dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion

Boeddinghaus, Christine, Merz, Alexey J., Laage, Rico, Ungermann, Christian

Vacuole fusion requires a coordinated cascade of priming, docking, and fusion. SNARE proteins have been implicated in the fusion itself, although their precise role in the cascade remains unclear. We...