Rikard Holmdahl

The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis (2009)

Ahlqvist, Emma, Hultqvist, Malin, Holmdahl, Rikard

Abstract For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also...

Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes (2009)

Lindvall, Therese, Karlsson, Jenny, Holmdahl, Rikard, Andersson, Åsa

Abstract Introduction In a cross between two mouse strains, the susceptible B10.RIII (H-2 r ) and resistant RIIIS/J (H-2 r ) strains, a locus on mouse chromosome 5 ( Eae39 ) was previously shown to...

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock (2009)

Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blázquez, Gloria, ...

The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular,...

Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis (2008)

Geng, Hui, Carlsen, Stefan, Nandakumar, Kutty, Holmdahl, Rikard, Aspberg, Anders, Oldberg, Åke, ...

Abstract Introduction Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a...

Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2fragments (2008)

Liljander, Maria, Andersson, Åsa, Holmdahl, Rikard, Mattsson, Ragnar

Abstract Introduction Collagen-induced arthritis (CIA) in mice is a commonly used experimental model for rheumatoid arthritis (RA). We have previously identified a significant quantitative trait...

The influence of the NOD Nss1/Idd5loci on sialadenitis and gene expression in salivary glands of congenic mice (2007)

Hjelmervik, Trond, Lindqvist, Anna-Karin, Petersen, Kjell, Johannesson, Martina, Stavrum, Anne-Kristin, Johansson, Åsa, ...

Abstract The nonobese diabetic (NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control...

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4gene, supporting a role for the NADPH-oxidase complex in autoimmunity (2007)

Olsson, Lina M, Lindqvist, Anna-Karin, Källberg, Henrik, Padyukov, Leonid, Burkhardt, Harald, Alfredsson, Lars, ...

Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been...

Arthritis suppression by NADPH activation operates through an interferon-β pathway (2007)

Olofsson, Peter, Nerstedt, Annika, Hultqvist, Malin, Nilsson, Elisabeth C, Andersson, Sofia, Bergelin, Anna, ...

Abstract Background A polymorphism in the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCF1), has previously been...

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis (2007)

Nandakumar, Kutty, Holmdahl, Rikard

Abstract During the development of rheumatoid arthritis (RA) autoantibodies to IgG-Fc, citrullinated proteins, collagen type II (CII), glucose 6 phosphoisomerase (G6PI) and some other self-antigens...

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. (2007)

Nandakumar, Kutty, Holmdahl, Rikard

Abstract is not available

Type II collagen without adjuvant induces eosinophilic arthritis. (2007)

Bockermann, Robert, Holmdahl, Rikard

Abstract is not available

Aire-ing self antigen variability and tolerance. (2007)

Holmdahl, Rikard

Abstract is not available

Fragmentation of two quantitative trait Loci controlling collagen-induced arthritis reveals a new set of interacting subloci. (2007)

Ahlqvist, Emma, Bockermann, Robert, Holmdahl, Rikard

Abstract is not available

Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity. (2007)

Holmdahl, Rikard

Abstract is not available

Quantitative Structure-Activity Relationship of Peptides Binding to the Class II Major Histocompatibility Complex Molecule A(q) Associated with Autoimmune Arthritis. (2007)

Holm, Lotta, Frech, Kristina, Dzhambazov, Balik, Holmdahl, Rikard, Kihlberg, Jan, Linusson, Anna

Abstract is not available

Monoclonal Antibody Production Using a New Supermacroporous Cryogel Bioreactor. (2007)

Nilsang, Suthasinee, Nandakumar, Kutty, Galaev, Igor, Rakshit, Sudip, Holmdahl, Rikard, Mattiasson, Bo, ...

Abstract is not available

Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice. (2007)

Hultqvist, Malin, Backlund, Johan, Bauer, Kristin, Gelderman, Kyra A, Holmdahl, Rikard

Abstract is not available

Rheumatoid Arthritis: The Role of Reactive Oxygen Species in Disease Development and Therapeutic Strategies. (2007)

Gelderman, Kyra A, Hultqvist, Malin, Olsson, Lina M, Bauer, Kristin, Pizzolla, Angela, Olofsson, Peter, ...

Abstract is not available

Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis. (2007)

Nandakumar, Kutty Selva, Collin, Mattias, Olsén, Arne, Nimmerjahn, Falk, Blom, Anna M, Ravetch, Jeffrey V, ...

Abstract is not available

Rheumatoid arthritis and the complement system. (2007)

Okroj, Marcin, Heinegard, Dick, Holmdahl, Rikard, Blom, Anna M

Abstract is not available

Probing Molecular Interactions within Class II MHC A(q)/Glycopeptide/T-Cell Receptor Complexes Associated with Collagen-Induced Arthritis. (2007)

Andersson, Ida, Dzhambazov, Balik, Holmdahl, Rikard, Linusson, Anna, Kihlberg, Jan

Abstract is not available

Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. (2007)

Nandakumar, Kutty Selva, Johansson, Bjorn P, Bjorck, Lars, Holmdahl, Rikard

Abstract is not available

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. (2007)

Gelderman, Kyra A, Hultqvist, Malin, Pizzolla, Angela, Zhao, Ming, Nandakumar, Kutty Selva, Mattsson, Ragnar, ...

Abstract is not available

Pristane-induced arthritis in the rat. (2007)

Olofsson, Peter, Holmdahl, Rikard

Abstract is not available

Arthritis induced with minor cartilage proteins. (2007)

Carlsen, Stefan, Lu, Shemin, Holmdahl, Rikard

Abstract is not available

Collagen antibody induced arthritis. (2007)

Nandakumar, Kutty Selva, Holmdahl, Rikard

Abstract is not available

The use of animal models for rheumatoid arthritis. (2007)

Holmdahl, Rikard

Abstract is not available

A New Arthritis Therapy with Oxidative Burst Inducers (2006)

Malin Hultqvist, Peter Olofsson, Kyra A. Gelderman, Jens Holmberg, Rikard Holmdahl

BackgroundDespite recent successes with biological agents as therapy for autoimmune inflammatory diseases such as rheumatoid arthritis (RA), many patients fail to respond adequately to these...

Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity (2006)

Carlsen, Stefan, Nandakumar, Kutty, Holmdahl, Rikard

Abstract Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen (CIX) is a protein of importance for cartilage integrity and stability. In this...

Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium (2006)

Sehnert, Bettina, Gierer, Philip, Ibrahim, Saleh, Kühl, Anja, Voll, Reinhard, Nandakumar, Kutty, ...

Abstract Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity....

Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitroand in vivoin HLA-DR1 transgenic mice (2006)

Von Delwig, Alexei, Hilkens, Catharien MU, Altmann, Daniel M, Holmdahl, Rikard, Isaacs, John D, Harding, Clifford V, ...

Abstract Professional antigen-presenting cells, such as dendritic cells, macrophages and B cells have been implicated in the pathogenesis of rheumatoid arthritis, constituting a possible target for...

Identification of collagen-induced arthritis loci in aged multiparous female mice (2006)

Liljander, Maria, Sällström, Mary-Ann, Andersson, Sara, Andersson, Åsa, Holmdahl, Rikard, Mattsson, Ragnar

Abstract Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a...

Therapeutic Vaccination of Active Arthritis with a Glycosylated Collagen Type II Peptide in Complex with MHC Class II Molecules. (2006)

Dzhambazov, Balik, Nandakumar, Kutty Selva, Kihlberg, Jan, Fugger, Lars, Holmdahl, Rikard, Vestberg, Mikael

Abstract is not available

Dissection of the genetic complexity of arthritis using animal models. (2006)

Holmdahl, Rikard

Abstract is not available

Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. (2006)

Holmberg, Jens, Tuncel, Jonatan, Yamada, Hisakata, Lu, Shemin, Olofsson, Peter, Holmdahl, Rikard

Abstract is not available

Identification of Genetic Regions of Importance for Reproductive Performance in Female Mice. (2006)

Liljander, Maria, Sallstrom, Mary-Ann, Andersson, Sara, Wernhoff, Patrik, Andersson, Asa, Holmdahl, Rikard, ...

Abstract is not available

Identification of collagen-induced arthritis loci in aged multiparous female mice. (2006)

Liljander, Maria, Sallstrom, Mary-Ann, Andersson, Sara, Andersson, Asa, Holmdahl, Rikard, Mattsson, Ragnar

Abstract is not available

Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. (2006)

Nandakumar, Kutty Selva, Holmdahl, Rikard

Abstract is not available

Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity. (2006)

Carlsen, Stefan, Nandakumar, Kutty, Holmdahl, Rikard

Abstract is not available

T cell surface redox levels determine T cell reactivity and arthritis susceptibility. (2006)

Gelderman, Kyra A, Hultqvist, Malin, Holmberg, Jens, Olofsson, Peter, Holmdahl, Rikard

Abstract is not available

Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci. (2006)

Lindqvist, Anna-Karin B, Johannesson, Martina, Johansson, Asa C M, Nandakumar, Kutty S, Blom, Anna M, Holmdahl, Rikard

Abstract is not available

Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice. (2006)

Von Delwig, Alexei, Hilkens, Catharien MU, Altmann, Daniel M, Holmdahl, Rikard, Isaacs, John D, Harding, Clifford V, ...

Professional antigen-presenting cells, such as dendritic cells, macrophages and B cells have been implicated in the pathogenesis of rheumatoid arthritis, constituting a possible target for...

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase (2005)

Bockermann, Robert, Schubert, David, Kamradt, Thomas, Holmdahl, Rikard

Abstract Antibodies specific for glucose-6-phosphate isomerase (G6PI) from T-cell receptor transgenic K/BxN mice are known to induce arthritis in mice, and immunization of DBA/1 mice with G6PI led to...

Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen (2005)

Bajtner, Estelle, Nandakumar, Kutty S, Engström, Åke, Holmdahl, Rikard

Abstract Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine...

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro (2005)

Crombie, Duncan E, Turer, Muhammed, Zuasti, Beltzane, Wood, Bayden, McNaughton, Don, Nandakumar, Kutty, ...

Abstract Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of...

Perforin deficiency attenuates collagen-induced arthritis (2005)

Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...

Abstract Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8 + T cells are a major subset...

Genetic Interactions in Eae2 Control Collagen-Induced Arthritis and the CD4+/CD8+ T Cell Ratio. (2005)

Karlsson, Jenny, Johannesson, Martina, Lindvall, Therese, Wernhoff, Patrik, Holmdahl, Rikard, Andersson, Asa

Abstract is not available

A genetic contamination in MHC-congenic mouse strains reveals a locus on chromosome 10 that determines autoimmunity and arthritis susceptibility. (2005)

Nandakumar, Kutty Selva, Holmdahl, Rikard

Abstract is not available

Intrinsic Tolerance in Autologous Collagen-Induced Arthritis Is Generated by CD152-Dependent CD4+ Suppressor Cells. (2005)

Treschow, Alexandra P, Bäcklund, Johan, Holmdahl, Rikard, Issazadeh-Navikas, Shohreh

Abstract is not available

Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice. (2005)

Hultqvist, Malin, Holmdahl, Rikard

Abstract is not available

A genetic basis for shared autoimmunity in mouse models. (2005)

Andersson, Asa, Holmdahl, Rikard

Abstract is not available

Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis. (2005)

Nandakumar, Kutty Selva, Holmdahl, Rikard

Abstract is not available

Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen. (2005)

Bajtner, Estelle, Nandakumar, Kutty S, Engstrom, Ake, Holmdahl, Rikard

Abstract is not available

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase. (2005)

Bockermann, Robert, Schubert, David, Kamradt, Thomas, Holmdahl, Rikard

Abstract is not available

Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice. (2005)

Treschow, Alexandra P, Teige, Ingrid, Nandakumar, Kutty S, Holmdahl, Rikard, Issazadeh-Navikas, Shohreh

Abstract is not available

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells (2004)

Nandakumar, Kutty, Bäcklund, Johan, Vestberg, Mikael, Holmdahl, Rikard

Abstract Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B...

Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice (2004)

Hansson, Ann-Sofie, Johansson, Åsa CM, Holmdahl, Rikard

Abstract Relapsing polychondritis (RP) is an autoimmune disease that affects extra-articular cartilage. Matrilin-1-induced relapsing polychondritis (MIRP) is a model for RP and is useful for studies...

CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis. (2004)

Teige, Anna, Teige, Ingrid, Lavasani, Shahram, Bockermann, Robert, Mondoc, Emma, Holmdahl, Rikard, ...

The existence of T cells restricted for the MHC I-like molecule CD1 is well established, but the function of these cells is still obscure; one implication is that CD1-dependent T cells regulate...

Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers. (2004)

Huang, Jason C., Vestberg, Mikael, Minguela, Alfredo, Holmdahl, Rikard, Ward, E. Sally

CD4+ T cells that recognize residues 256–270 of type II collagen (CII) associated with the I-Aq (Aq) molecule play a central role in disease pathogenesis in murine collagen-induced arthritis (CIA)....

Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis. (2004)

Rostrom, B, Grubb, Anders, Holmdahl, Rikard

Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune...

Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells. (2004)

Holmdahl, Meirav, Grubb, Anders, Holmdahl, Rikard

Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on activation of CII-reactive T cells. Dendritic cells (DCs) are believed to play a crucial role in antigen-specific priming...

Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1. (2004)

Olofsson, Peter, Johansson, Asa, Wedekind, Dirk, Klöting, Ingrid, Klinga-Levan, Karin, Lu, Shemin, ...

Abstract is not available

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. (2004)

Hultqvist, Malin, Olofsson, Peter, Holmberg, Jens, Bäckström, B Thomas, Tordsson, Jesper, Holmdahl, Rikard

Abstract is not available

A Transient Post-Translationally Modified Form of Cartilage Type II Collagen Is Ignored by Self-Reactive T Cells. (2004)

Yamada, Hisakata, Dzhambazov, Balik, Bockermann, Robert, Blom, Thomas, Holmdahl, Rikard

Abstract is not available

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. (2004)

Kutty Selva, Nandakumar, Bäcklund, Johan, Vestberg, Mikael, Holmdahl, Rikard

Abstract is not available

Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry (2004)

Xu, Yuekang, Ramsland, Paul A., Davies, Janet M., Scealy, Marita, Nandakumar, Kutty Selva, Holmdahl, Rikard, ...

Two monoclonal antibodies (mAb) CB268 and CII-C1 to type II collagen (CII) react with precisely the same conformational epitope constituted by the residues ARGLT on the three chains of the CII triple...

Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells (2004)

Holmdahl, Meirav, Grubb, Anders, Holmdahl, Rikard

Development of type‐II collagen (CII)‐induced arthritis (CIA) is dependent on activation of CII‐reactive T cells. Dendritic cells (DCs) are believed to play a crucial role in...

Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers (2004)

Huang, Jason C., Vestberg, Mikael, Minguela, Alfredo, Holmdahl, Rikard, Ward, E. Sally

CD4+ T cells that recognize residues 256–270 of type II collagen (CII) associated with the I‐Aq (Aq) molecule play a central role in disease pathogenesis in murine collagen‐induced...

Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats (2003)

Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...

Abstract Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph...

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. (2003)

Olofsson, Peter, Holmberg, Jens, Tordsson, Jesper, Lu, Shemin, Akerström, Bo, Holmdahl, Rikard

Abstract is not available

Novel quantitative trait Loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. (2003)

Karlsson, Jenny, Zhao, Xiangshan, Lonskaya, Irina, Neptin, Malin, Holmdahl, Rikard, Andersson, Asa

Abstract is not available

Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease". (2003)

Blom, Thomas, Franzén, Ahnders, Heinegård, Dick, Holmdahl, Rikard

Abstract not available

IFN-beta Gene Deletion Leads to Augmented and Chronic Demyelinating Experimental Autoimmune Encephalomyelitis. (2003)

Teige, Ingrid, Treschow, Alexandra, Teige, Anna, Mattsson, Ragnar, Navikas, Vaidrius, Leanderson, Tomas, ...

Abstract is not available

Identification and isolation of dominant susceptibility Loci for pristane-induced arthritis. (2003)

Olofsson, Peter, Holmberg, Jens, Pettersson, Ulf, Holmdahl, Rikard

Abstract is not available

Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. (2003)

Nandakumar, Kutty Selva, Andrén, Maria, Martinsson, Pernilla, Bajtner, Estelle, Hellström, Silvia, Holmdahl, Rikard, ...

Abstract is not available

Dissection of the genetic complexity of arthritis using animal models. (2003)

Holmdahl, Rikard

Abstract is not available

A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis. (2003)

Olofsson, Peter, Lu, Shemin, Holmberg, Jens, Song, Tusheng, Wernhoff, Patrik, Pettersson, Ulf, ...

Abstract is not available

Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model. (2003)

Bäcklund, Johan, Nandakumar, Kutty Selva, Bockermann, Robert, Mori, Lucia, Holmdahl, Rikard

Abstract is not available

Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6. (2003)

Olofsson, Peter, Wernhoff, Patrik, Holmberg, Jens, Holmdahl, Rikard

Abstract is not available

The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. (2003)

Wernhoff, Patrik, Olofsson, Peter, Holmdahl, Rikard

Abstract is not available

Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats (2003)

Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...

Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...

Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis (2002)

Hansson, Ann-Sofie, Holmdahl, Rikard

Abstract Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage...

Genetic links between the acute-phase response and arthritis development in rats. (2002)

Olofsson, Peter, Nordquist, Niklas, Vingsbo-Lundberg, Carina, Larsson, Anders, Falkenberg, Cecilia, Pettersson, Ulf, ...

OBJECTIVE: The acute-phase inflammatory response is closely correlated with the development of rheumatoid arthritis, but the pathophysiologic role of its specific components is largely unknown. We...

The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross. (2002)

Johansson, Asa C M, Nakken, Britt, Sundler, Martin, Lindqvist, Anna-Karin B, Johannesson, Martina, Alarcón-Riquelme, Marta, ...

The non-obese diabetic (NOD) mouse spontaneously develops diabetes and sialadenitis. The sialadenitis is characterized by histopathological changes in salivary glands and functional deficit similar...

Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus. (2002)

Jirholt, Johan, Lindqvist, Anna-Karin, Karlsson, Jenny, Andersson A, Asa, Holmdahl, Rikard

We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and...

The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis. (2002)

Holmdahl, Rikard, Bockermann, Robert, Bäcklund, Johan, Yamada, Hisakata

The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for...

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. (2002)

Levéen, Per, Larsson, Jonas, Ehinger, Mats, Cilio, Corrado M, Sundler, Martin, Sjöstrand, Lottie Jansson, ...

Recent studies in mouse models deficient in transforming growth factor beta (TGF-beta) signaling have documented TGF-beta as one of the major regulators of immune function. TGF-beta1-null animals...

Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. (2002)

Lu, Shemin, Nordquist, Niklas, Holmberg, Jens, Olofsson, Peter, Pettersson, Ulf, Holmdahl, Rikard

Pristane-induced arthritis (PIA) in rats is an animal model for rheumatoid arthritis (RA). We have previously identified seven quantitative trait loci (QTLs), which regulate arthritis development...

A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination. (2002)

Svensson, Lars, Abdul-Majid, Khairul-Bariah, Bauer, Jan, Lassmann, Hans, Harris, Robert A, Holmdahl, Rikard

We have investigated the role of B cells in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) using B cell-deficient mice muMT) and mice bearing the...

Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection. (2002)

Bäcklund, Johan, Treschow, Alexandra, Firan, Mihail, Malmström, Vivianne, Issazadeh-Navikas, Shohreh, Ward, E Sally, ...

Collagen-induced arthritis (CIA) is induced in H-2(q) mice after immunization with rat type II collagen (CII). The immunodominant T cell epitope on heterologous CII has been located to CII256-270. We...

Immunization of Rats with Homologous Type XI Collagen Leads to Chronic and Relapsing Arthritis with Different Genetics and Joint Pathology Than Arthritis Induced with Homologous Type II Collagen. (2002)

Lu, Shemin, Carlsen, Stefan, Hansson, Ann Sofie, Holmdahl, Rikard

The most commonly used animal model for rheumatoid arthritis (RA) is collagen-induced arthritis (CIA), induced by immunization with type II collagen (CII), a cartilage restricted protein. In this...

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis. (2002)

Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis. (2002)

Svensson, Lars, Nandakumar, Kutty Selva, Johansson, Asa, Jansson, Liselotte, Holmdahl, Rikard

Rheumatoid arthritis as well as collagen-induced arthritis (CIA) is thought to involve T cell autoimmunity of the Th1 type and the Th2 cytokine IL-4 has been proposed to play a suppressive role. To...

Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis. (2002)

Bäcklund, Johan, Treschow, Alexandra, Bockermann, Robert, Holm, Björn, Holm, Lotta, Issazadeh-Navikas, Shohreh, ...

Abstract is not available

Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus (2002)

Jirholt, Johan, Lindqvist, Anna-Karin, Karlsson, Jenny, Andersson, Åsa, Holmdahl, Rikard

We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and...

Arthritis induced in rats with non-immunogenic adjuvants as models for rheumatoid arthritis (2001)

Holmdahl, Rikard, Lorentzen, Johnny C., Lu, Shemin, Olofsson, Peter, Wester, Lena, Holmberg, Jens, ...

Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the...

Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases (2001)

Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...

Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...

Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases (2001)

Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...

Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...

Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases (2001)

Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...

Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...

Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases (2001)

Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...

Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...

Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat (2001)

Wernhoff, Patrik, Unger, Christine, Bajtner, Estelle, Burkhardt, Harald, Holmdahl, Rikard

Collagen-induced arthritis (CIA) is a widely used model for rheumatoid arthritis. Induction of CIA in rats using rat type II collagen (CII) results in a chronic arthritis in which anti-CII antibodies...

The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes (2000)

Jirholt, Johan, Lindqvist, Anna-Karin B, Holmdahl, Rikard

Abstract The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for...

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis (2000)

Malmström, Vivianne, Bäcklund, Johan, Jansson, Liselotte, Kihlberg, Jan, Holmdahl, Rikard

Statement of findings The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which...

Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction (2000)

Holmdahl, Rikard

No abstract available.

Rheumatoid arthritis viewed using a headache paradigm (2000)

Holmdahl, Rikard

Abstract Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the...

Collagen Type II-Specific Autoantibodies in Chronic Inflammatory Joint Diseases (1999)

Burkhardt, Harald, Unger, Christine, Kraetsch, Hans-Georg, Koller, Tobias, Kalden, Joachim R, Wernhof, Patrik, ...

No abstract available.

Genetic Studies in Experimental Arthritis (1999)

Holmdahl, Rikard

No abstract available.

Collagen-induced arthritis development requires {alpha}{beta} T cells but not {gamma}{delta} T cells: studies with T cell-deficient (TCR mutant) mice (1999)

Corthay, Alexandre, Johansson, Åsa, Vestberg, Mikael, Holmdahl, Rikard

Collagen type II (CII)-induced arthritis (CIA) in mice is a model for rheumatoid arthritis (RA) in which the role of T lymphocytes remains controversial. To clarify this, we have bred a targeted gene...

Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity (1999)

De Graaf, Katrien L., Weissert, Robert, Kjellén, Peter, Holmdahl, Rikard, Olsson, Tomas

The impact of the strength and promiscuity of the self peptide–MHC class II interaction on susceptibility to autoimmune disease is uncertain. Here we studied allelic differences in the affinity of...

Collagen induced arthritis :--pathogenetic mechanisms and relevance for rheumatoid arthritis /--by Rikard Holmdahl. (1985)

Holmdahl, Rikard.

Thesis (doctoral)--Uppsala University, 1985.

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

Malmström, Vivianne, Bäcklund, Johan, Jansson, Liselotte, Kihlberg, Jan, Holmdahl, Rikard

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the...

Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, ...

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and...

Are B Lymphocytes of Importance in Severe Staphylococcus aureus Infections?

Gjertsson, Inger, Hultgren, Olof Hörnquist, Stenson, Martin, Holmdahl, Rikard, Tarkowski, Andrzej

To investigate the role of B cells in experimental, superantigen-mediated Staphylococcus aureus arthritis and sepsis, we used gene-targeted B-cell-deficient mice. The mice were inoculated...

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...

The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes

Jirholt, Johan, Lindqvist, Anna-Karin B, Holmdahl, Rikard

The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that...

Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis

Hansson, Ann-Sofie, Holmdahl, Rikard

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is...

Rheumatoid arthritis viewed using a headache paradigm

Holmdahl, Rikard

Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection...

Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction

Holmdahl, Rikard

Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats

Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...

Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...

A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)

Hansson, Ann-Sofie, Heinegård, Dick, Holmdahl, Rikard

Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears....

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

Hultqvist, Malin, Olofsson, Peter, Holmberg, Jens, Bäckström, B. Thomas, Tordsson, Jesper, Holmdahl, Rikard

The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele mediated a lower level of reactive oxygen...

Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice

Hansson, Ann-Sofie, Johansson, Åsa CM, Holmdahl, Rikard

Relapsing polychondritis (RP) is an autoimmune disease that affects extra-articular cartilage. Matrilin-1-induced relapsing polychondritis (MIRP) is a model for RP and is useful for studies of the...

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

Nandakumar, Kutty Selva, Bäcklund, Johan, Vestberg, Mikael, Holmdahl, Rikard

Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in...

Perforin deficiency attenuates collagen-induced arthritis

Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...

Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling...

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro

Crombie, Duncan E, Turer, Muhammed, Zuasti, Beltzane Biurrun, Wood, Bayden, McNaughton, Don, Nandakumar, Kutty Selva, ...

Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen...

Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen

Bajtner, Estelle, Nandakumar, Kutty S, Engström, Åke, Holmdahl, Rikard

Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine specificity and...

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase

Bockermann, Robert, Schubert, David, Kamradt, Thomas, Holmdahl, Rikard

Antibodies specific for glucose-6-phosphate isomerase (G6PI) from T-cell receptor transgenic K/BxN mice are known to induce arthritis in mice, and immunization of DBA/1 mice with G6PI led to acute...

Identification of collagen-induced arthritis loci in aged multiparous female mice

Liljander, Maria, Sällström, Mary-Ann, Andersson, Sara, Andersson, Åsa, Holmdahl, Rikard, Mattsson, Ragnar

Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex...

Identification of Genetic Regions of Importance for Reproductive Performance in Female Mice

Liljander, Maria, Sällström, Mary-Ann, Andersson, Sara, Wernhoff, Patrik, Andersson, Åsa, Holmdahl, Rikard, ...

Both environmental and genetic factors can dramatically affect reproductive performance in mice. In this study we have focused on the identification of genetic regions, quantitative trait loci (QTL),...

A New Arthritis Therapy with Oxidative Burst Inducers

Hultqvist, Malin, Olofsson, Peter, Gelderman, Kyra A, Holmberg, Jens, Holmdahl, Rikard

Treatment of arthritis in rats with phytol, a reactive oxygen species promoting substance, suggests a novel pathway of autoimmune inflammatory disease and possibly a novel therapeutic strategy.

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

Malmström, Vivianne, Bäcklund, Johan, Jansson, Liselotte, Kihlberg, Jan, Holmdahl, Rikard

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the...

Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, ...

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and...

Are B Lymphocytes of Importance in Severe Staphylococcus aureus Infections?

Gjertsson, Inger, Hultgren, Olof Hörnquist, Stenson, Martin, Holmdahl, Rikard, Tarkowski, Andrzej

To investigate the role of B cells in experimental, superantigen-mediated Staphylococcus aureus arthritis and sepsis, we used gene-targeted B-cell-deficient mice. The mice were inoculated...

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...

The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes

Jirholt, Johan, Lindqvist, Anna-Karin B, Holmdahl, Rikard

The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that...

Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis

Hansson, Ann-Sofie, Holmdahl, Rikard

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is...

Rheumatoid arthritis viewed using a headache paradigm

Holmdahl, Rikard

Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection...

Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction

Holmdahl, Rikard

Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats

Wester, Lena, Koczan, Dirk, Holmberg, Jens, Olofsson, Peter, Thiesen, Hans-Jürgen, Holmdahl, Rikard, ...

Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of...

A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)

Hansson, Ann-Sofie, Heinegård, Dick, Holmdahl, Rikard

Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears....

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

Hultqvist, Malin, Olofsson, Peter, Holmberg, Jens, Bäckström, B. Thomas, Tordsson, Jesper, Holmdahl, Rikard

The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This finding was surprising, because the disease-promoting allele mediated a lower level of reactive oxygen...

Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice

Hansson, Ann-Sofie, Johansson, Åsa CM, Holmdahl, Rikard

Relapsing polychondritis (RP) is an autoimmune disease that affects extra-articular cartilage. Matrilin-1-induced relapsing polychondritis (MIRP) is a model for RP and is useful for studies of the...

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

Nandakumar, Kutty Selva, Bäcklund, Johan, Vestberg, Mikael, Holmdahl, Rikard

Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in...

Perforin deficiency attenuates collagen-induced arthritis

Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, ...

Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling...

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro

Crombie, Duncan E, Turer, Muhammed, Zuasti, Beltzane Biurrun, Wood, Bayden, McNaughton, Don, Nandakumar, Kutty Selva, ...

Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen...

Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen

Bajtner, Estelle, Nandakumar, Kutty S, Engström, Åke, Holmdahl, Rikard

Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine specificity and...

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase

Bockermann, Robert, Schubert, David, Kamradt, Thomas, Holmdahl, Rikard

Antibodies specific for glucose-6-phosphate isomerase (G6PI) from T-cell receptor transgenic K/BxN mice are known to induce arthritis in mice, and immunization of DBA/1 mice with G6PI led to acute...

Identification of Genetic Regions of Importance for Reproductive Performance in Female Mice

Liljander, Maria, Sällström, Mary-Ann, Andersson, Sara, Wernhoff, Patrik, Andersson, Åsa, Holmdahl, Rikard, ...

Both environmental and genetic factors can dramatically affect reproductive performance in mice. In this study we have focused on the identification of genetic regions, quantitative trait loci (QTL),...

Identification of collagen-induced arthritis loci in aged multiparous female mice

Liljander, Maria, Sällström, Mary-Ann, Andersson, Sara, Andersson, Åsa, Holmdahl, Rikard, Mattsson, Ragnar

Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex...

A New Arthritis Therapy with Oxidative Burst Inducers

Hultqvist, Malin, Olofsson, Peter, Gelderman, Kyra A, Holmberg, Jens, Holmdahl, Rikard

Treatment of arthritis in rats with phytol, a reactive oxygen species promoting substance, suggests a novel pathway of autoimmune inflammatory disease and possibly a novel therapeutic strategy.

Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice

Von Delwig, Alexei, Hilkens, Catharien MU, Altmann, Daniel M, Holmdahl, Rikard, Isaacs, John D, Harding, Clifford V, ...

Professional antigen-presenting cells, such as dendritic cells, macrophages and B cells have been implicated in the pathogenesis of rheumatoid arthritis, constituting a possible target for...

Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium

Sehnert, Bettina, Gierer, Philip, Ibrahim, Saleh, Kühl, Anja, Voll, Reinhard, Nandakumar, Kutty Selva, ...

Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity. On the...

Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity

Carlsen, Stefan, Nandakumar, Kutty Selva, Holmdahl, Rikard

Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen (CIX) is a protein of importance for cartilage integrity and stability. In this study we...

Influence of CD4 or CD8 deficiency on collagen-induced arthritis

Ehinger, Magnus, Vestberg, Mikael, Johansson, Åsa C M, Johannesson, Martina, Svensson, Anders, Holmdahl, Rikard

The role of T cells in the mouse collagen-induced arthritis (CIA) model for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells....

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis

Nandakumar, Kutty Selva, Holmdahl, Rikard

During the development of rheumatoid arthritis (RA) autoantibodies to IgG-Fc, citrullinated proteins, collagen type II (CII), glucose 6 phosphoisomerase (G6PI) and some other self-antigens appear. Of...

T cell surface redox levels determine T cell reactivity and arthritis susceptibility

Gelderman, Kyra A., Hultqvist, Malin, Holmberg, Jens, Olofsson, Peter, Holmdahl, Rikard

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to...

Basal metabolic rate and the evolution of the adaptive immune system.

Råberg, Lars, Vestberg, Mikael, Hasselquist, Dennis, Holmdahl, Rikard, Svensson, Erik, Nilsson, Jan-Ake

Vertebrates have evolved an adaptive immune system in addition to the ancestral innate immune system. It is often assumed that a trade-off between costs and benefits of defence governs the evolution...

The Plasminogen Activator/Plasmin System Is Essential for Development of the Joint Inflammatory Phase of Collagen Type II-Induced Arthritis

Li, Jinan, Ny, Annelii, Leonardsson, Göran, Nandakumar, Kutty Selva, Holmdahl, Rikard, Ny, Tor

The plasminogen activator (PA) system has been proposed to have important roles in rheumatoid arthritis. Here we have used the autoimmune collagen type II (CII)-induced arthritis (CIA) model and mice...

Relapsing Polychondritis, Induced in Mice with Matrilin 1, Is an Antibody- and Complement-Dependent Disease

Hansson, Ann-Sofie, Johannesson, Martina, Svensson, Lars, Nandakumar, Kutty Selda, Heinegård, Dick, Holmdahl, Rikard

Relapsing polychondritis is an autoimmune disease that affects cartilage in the ear, nose, and respiratory tract. A pathogenic immune response has been proposed and antibodies to several cartilage...

Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase

Crandall, Hillary, Ma, Ying, Dunn, Diane M., Sundsbak, Rhianna S., Zachary, James F., Olofsson, Peter, ...

Several quantitative trait loci regulating murine Lyme arthritis severity have been mapped, including a highly significant linkage found on chromosome 5, termed Bb2Bb3. Within this region, the Ncf1...

Arthritis suppression by NADPH activation operates through an interferon-β pathway

Olofsson, Peter, Nerstedt, Annika, Hultqvist, Malin, Nilsson, Elisabeth C, Andersson, Sofia, Bergelin, Anna, ...

Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice : Description of the Disease and the Influence of Age, Sex, and Genes

Nandakumar, Kutty Selva, Svensson, Lars, Holmdahl, Rikard

Transfer of collagen type II (CII)-specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody-induced arthritis, CAIA) in naïve mice. Arthritis was induced using a...

Ethanol prevents development of destructive arthritis

Jonsson, Ing-Marie, Verdrengh, Margareta, Brisslert, Mikael, Lindblad, Sofia, Bokarewa, Maria, Islander, Ulrika, ...

Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity...

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

Gelderman, Kyra A., Hultqvist, Malin, Pizzolla, Angela, Zhao, Ming, Nandakumar, Kutty Selva, Mattsson, Ragnar, ...

Reduced capacity to produce ROS increases the severity of T cell–dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot...

The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice

Hjelmervik, Trond Ove R, Lindqvist, Anna-Karin, Petersen, Kjell, Johannesson, Martina, Stavrum, Anne-Kristin, Johansson, Åsa, ...

The nonobese diabetic (NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control strain...

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity

Olsson, Lina M, Lindqvist, Anna-Karin, Källberg, Henrik, Padyukov, Leonid, Burkhardt, Harald, Alfredsson, Lars, ...

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been...

Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments

Liljander, Maria, Andersson, Åsa, Holmdahl, Rikard, Mattsson, Ragnar

Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats

Rintisch, Carola, Ameri, Jacqueline, Olofsson, Peter, Luthman, Holger, Holmdahl, Rikard

Rheumatoid factors (RF), autoantibodies that bind the Fc region of IgG, are one of the major diagnostic marker in rheumatoid arthritis (RA) but occur with lower frequency also in other infectious and...

Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis

Geng, Hui, Carlsen, Stefan, Nandakumar, Kutty Selva, Holmdahl, Rikard, Aspberg, Anders, Oldberg, Åke, ...

Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes

Lindvall, Therese, Karlsson, Jenny, Holmdahl, Rikard, Andersson, Åsa

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock

Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blázquez, Gloria, ...

The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular,...

The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis

Ahlqvist, Emma, Hultqvist, Malin, Holmdahl, Rikard

For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to...

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis

Uysal, Hüseyin, Bockermann, Robert, Nandakumar, Kutty S., Sehnert, Bettina, Bajtner, Estelle, Engström, Åke, ...

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into...