Host-pathogen interactions in campylobacter infections: the host perspective (2008)
Janssen, Riny, Krogfelt, Karen A., Cawthraw, Shaun A., Pelt, Wilfrid Van, Wagenaar, J.A., Owen, Robert J.
Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide (3). The incidence of human campylobacteriosis increased exponentially during the last decade of the 20th century (183),...
Janssen, Riny, Wauben, Marca, Der Zee, Ruurd Van, De Gast, Manja, Tommassen, Jan
CD4+ helper T cells recognize antigen in association with MHC class II molecules. To investigate the role of the context of a minimal T cell epitope on presentation and recognition in...
Van Der Straaten, Tahar, Van Diepen, Angela, Kwappenberg, Kitty, Van Voorden, Sjaak, Franken, Kees, Janssen, Riny, ...
Upon contact with host cells, the intracellular pathogen Salmonella enterica serovar Typhimurium promotes its uptake, targeting, and survival in intracellular niches. In this process, the bacterium...
An Epitope Delivery System for Use with Recombinant Mycobacteria
Hetzel, Charlotte, Janssen, Riny, Ely, Sarah J., Kristensen, Nanna M., Bunting, Karen, Cooper, Jonathan B., ...
We have developed a novel epitope delivery system based on the insertion of peptides within a permissive loop of a bacterial superoxide dismutase molecule. This system allowed high-level expression...
Van Diepen, Angela, Van Der Straaten, Tahar, Holland, Steven M., Janssen, Riny, Van Dissel, Jaap T.
Salmonella enterica serovar Typhimurium is a gram-negative, facultative intracellular pathogen that predominantly invades mononuclear phagocytes and is able to establish persistent infections. One of...
Van Der Straaten, Tahar, Zulianello, Laurence, Van Diepen, Angela, Granger, Donald L., Janssen, Riny, Van Dissel, Jaap T.
Escherichia coli and Salmonella enterica serovar Typhimurium have evolved genetic systems, such as the soxR/S and marA regulons, to detoxify reactive oxygen species, like superoxide, which are formed...
Salmonella Gene rma (ramA) and Multiple-Drug-Resistant Salmonella enterica Serovar Typhimurium
Van Der Straaten, Tahar, Janssen, Riny, Mevius, Dik J., Van Dissel, Jaap T.
MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of...
Van Diepen, Angela, Van De Gevel, Joke S., Koudijs, Margaretha M., Ossendorp, Ferry, Beekhuizen, Henry, Janssen, Riny, ...
Upon infection with Salmonella, a host develops an immune response to limit bacterial growth and kill and eliminate the pathogen. Salmonella has evolved mechanisms to remain dormant within the body,...
Van Der Straaten, Tahar, Van Diepen, Angela, Kwappenberg, Kitty, Van Voorden, Sjaak, Franken, Kees, Janssen, Riny, ...
Upon contact with host cells, the intracellular pathogen Salmonella enterica serovar Typhimurium promotes its uptake, targeting, and survival in intracellular niches. In this process, the bacterium...
An Epitope Delivery System for Use with Recombinant Mycobacteria
Hetzel, Charlotte, Janssen, Riny, Ely, Sarah J., Kristensen, Nanna M., Bunting, Karen, Cooper, Jonathan B., ...
We have developed a novel epitope delivery system based on the insertion of peptides within a permissive loop of a bacterial superoxide dismutase molecule. This system allowed high-level expression...
Van Diepen, Angela, Van Der Straaten, Tahar, Holland, Steven M., Janssen, Riny, Van Dissel, Jaap T.
Salmonella enterica serovar Typhimurium is a gram-negative, facultative intracellular pathogen that predominantly invades mononuclear phagocytes and is able to establish persistent infections. One of...
Van Der Straaten, Tahar, Zulianello, Laurence, Van Diepen, Angela, Granger, Donald L., Janssen, Riny, Van Dissel, Jaap T.
Escherichia coli and Salmonella enterica serovar Typhimurium have evolved genetic systems, such as the soxR/S and marA regulons, to detoxify reactive oxygen species, like superoxide, which are formed...
Salmonella Gene rma (ramA) and Multiple-Drug-Resistant Salmonella enterica Serovar Typhimurium
Van Der Straaten, Tahar, Janssen, Riny, Mevius, Dik J., Van Dissel, Jaap T.
MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of...
Van Diepen, Angela, Van De Gevel, Joke S., Koudijs, Margaretha M., Ossendorp, Ferry, Beekhuizen, Henry, Janssen, Riny, ...
Upon infection with Salmonella, a host develops an immune response to limit bacterial growth and kill and eliminate the pathogen. Salmonella has evolved mechanisms to remain dormant within the body,...
Host Transcription Profiles upon Primary Respiratory Syncytial Virus Infection▿ †
Janssen, Riny, Pennings, Jeroen, Hodemaekers, Hennie, Buisman, Annemarie, Van Oosten, Marijke, De Rond, Lia, ...
Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract infection in children. Severe RSV disease is related to an inappropriate immune response to RSV resulting in...
The Same IκBα Mutation in Two Related Individuals Leads to Completely Different Clinical Syndromes
Janssen, Riny, Van Wengen, Annelies, Hoeve, Marieke A., Ten Dam, Monique, Van Der Burg, Miriam, Van Dongen, Jacques, ...
Both innate and adaptive immune responses are dependent on activation of nuclear factor κB (NF-κB), induced upon binding of pathogen-associated molecular patterns to Toll-like receptors (TLRs). In...
Pennings, Jeroen L. A., Kimman, Tjeerd G., Janssen, Riny
To identify gene expression responses common to multiple pulmonary diseases we collected microarray data for acute lung inflammation models from 12 studies and used these in a meta-analysis. The data...
Host-Pathogen Interactions in Campylobacter Infections: the Host Perspective
Janssen, Riny, Krogfelt, Karen A., Cawthraw, Shaun A., Van Pelt, Wilfrid, Wagenaar, Jaap A., Owen, Robert J.
Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide. This study was aimed at summarizing the current understanding of host mechanisms involved in the defense against...