Morales, Monica, Theunissen, Jan-Willem F., Kim, Carla F. Bender, Kitagawa, Risa, Kastan, Michael B., Petrini, John H.J.
Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex...
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway (2004)
Kitagawa, Risa, Bakkenist, Christopher J., McKinnon, Peter J., Kastan, Michael B.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal...
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway (2004)
Kitagawa, Risa, Bakkenist, Christopher J., McKinnon, Peter J., Kastan, Michael B.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal...
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway (2004)
Kitagawa, Risa, Bakkenist, Christopher J., McKinnon, Peter J., Kastan, Michael B.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal...
Furuta, Tokiko, Tuck, Simon, Kirchner, Jay, Koch, Bryan, Auty, Roy, Kitagawa, Risa, ...
Here we show that emb-30 is required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Germline-specific emb-30 mutant alleles block the meiotic divisions....
Kitagawa, Risa, Ozaki, Toru, Moriya, Shigeki, Ogawa, Tohru
Replication of the Escherichia coli chromosome is initiated at a unique site, oriC. Concurrent initiation occurs at all oriC sites present in a cell once, and only once, per cell cycle. A mechanism...
Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway
Kitagawa, Risa, Bakkenist, Christopher J., McKinnon, Peter J., Kastan, Michael B.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal...
Morales, Monica, Theunissen, Jan-Willem F., Kim, Carla F. Bender, Kitagawa, Risa, Kastan, Michael B., Petrini, John H.J.
Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex...
Furuta, Tokiko, Tuck, Simon, Kirchner, Jay, Koch, Bryan, Auty, Roy, Kitagawa, Risa, ...
Here we show that emb-30 is required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Germline-specific emb-30 mutant alleles block the meiotic divisions....
Kitagawa, Risa, Ozaki, Toru, Moriya, Shigeki, Ogawa, Tohru
Replication of the Escherichia coli chromosome is initiated at a unique site, oriC. Concurrent initiation occurs at all oriC sites present in a cell once, and only once, per cell cycle. A mechanism...
Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway
Kitagawa, Risa, Bakkenist, Christopher J., McKinnon, Peter J., Kastan, Michael B.
The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate cell survival and reduce chromosomal...
Morales, Monica, Theunissen, Jan-Willem F., Kim, Carla F. Bender, Kitagawa, Risa, Kastan, Michael B., Petrini, John H.J.
Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex...
Tarailo, Maja, Kitagawa, Risa, Rose, Ann M.
The spindle assembly checkpoint (SAC) governs the timing of metaphase-to-anaphase transition and is essential for genome stability. The Caenorhabditis elegans mutant strain gk2 carries a deletion...
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
Bekker-Jensen, Simon, Lukas, Claudia, Kitagawa, Risa, Melander, Fredrik, Kastan, Michael B., Bartek, Jiri, ...
We show that DNA double-strand breaks (DSBs) induce complex subcompartmentalization of genome surveillance regulators. Chromatin marked by γ-H2AX is occupied by ataxia telangiectasia–mutated (ATM)...
Watanabe, Sonoko, Yamamoto, Takaharu G, Kitagawa, Risa
When newly hatched Caenorhabditis elegans larvae are starved, their primordial germ cells (PGCs) arrest in the post-S phase. This starvation-induced PGC arrest is mediated by the...
SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans
Yamamoto, Takaharu G., Watanabe, Sonoko, Essex, Anthony, Kitagawa, Risa
The spindle assembly checkpoint (SAC) ensures faithful chromosome segregation by delaying anaphase onset until all sister kinetochores are attached to bipolar spindles. An RNA interference screen for...