Robert Brasseur

Structural features conferring dual Geranyl/Farnesyl diphosphate synthase activity to an aphid prenyltransferase (2009)

Vandermoten, Sophie, Santini, Sebastien, Haubruge, Eric, Heuze, Fabien, Francis, Frederic, Brasseur, Robert, ...

In addition to providing lipid chains for protein prenylation, short-chain isoprenyl diphosphate synthases (scIPPSs) play a pivotal role in the biosynthesis of numerous mevalonate pathway...

Study of Thermomyces lanuginosa Lipase in the Presence of Tributyrylglycerol and Water (2009)

Santini, Sébastien, Crowet, Jean-Marc, Thomas, Annick, Paquot, Michel, Vandenbol, Micheline, Thonart, Philippe, ...

The Thermomyces lanuginosa lipase has been extensively studied in industrial and biotechnological research because of its potential for triacylglycerol transformation. This protein is known to...

Ir-LBP, an Ixodes ricinus Tick Salivary LTB4-Binding Lipocalin, Interferes with Host Neutrophil Function (2009)

Beaufays, Jérôme, Adam, Benoît, Menten-Dedoyart, Catherine, Fievez, Laurence, Grosjean, Amélie, Decrem, Yves, ...

Background : During their blood meal, ticks secrete a wide variety of proteins that can interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the...

Ir-LBP, an Ixodes ricinus Tick Salivary LTB4-Binding Lipocalin, Interferes with Host Neutrophil Function (2009)

Beaufays, Jérôme, Adam, Benoît, Menten-Dedoyart, Catherine, Fievez, Laurence, Grosjean, Amélie, Decrem, Yves, ...

Background : During their blood meal, ticks secrete a wide variety of proteins that can interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the...

Ixodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization (2009)

Beaufays, Jérôme, Adam, Benoît, Decrem, Yves, Prévôt, Pierre-Paul, Santini, Sébastien, Brasseur, Robert, ...

Background : During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the...

Ixodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization (2009)

Beaufays, Jérôme, Adam, Benoît, Decrem, Yves, Prévôt, Pierre-Paul, Santini, Sébastien, Brasseur, Robert, ...

Background : During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the...

Protein Engineering vol.12 no.1 pp.71–78, 1999 Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT) (2009)

Frank Peelman, Berlinda Vanloo, Oscar Perez-mendez, Anne Decout, Jean-luc Verschelde, Christine Labeur, ...

5To whom correspondence should be addressed. E-mail:

A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells. (2009)

Crombez, Laurence, Aldrian-Herrada, Gudrun, Konate, Karidia, Nguyen, Quan N, McMaster, Gary K, Brasseur, Robert, ...

RNA interference constitutes a powerful tool for biological studies, but has also become one of the most challenging therapeutic strategies. However, small interfering RNA (siRNA)-based strategies...

A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells. (2009)

Crombez, Laurence, Aldrian-Herrada, Gudrun, Konate, Karidia, Nguyen, Quan N, McMaster, Gary K, Brasseur, Robert, ...

RNA interference constitutes a powerful tool for biological studies, but has also become one of the most challenging therapeutic strategies. However, small interfering RNA (siRNA)-based strategies...

Calorimetric study of milk fat/rapeseed oil blends and their interesterification products (2009)

Aguedo, Mario, Giet, Jean-Michel, Hanon, Emilien, Lognay, Georges, Wathelet, Bernard, Destain, Jacqueline, ...

Milk fat (MF) and rapeseed oil (RO) blends were analyzed by differential scanning calorimetry (DSC). It was shown that peak and onset temperatures can be used to determine the percentage of each fat...

Genomic Location Of The Bovine Growth Hormone Secretagogue Receptor (Ghsr) Gene And Investigation Of Genetic Polymorphism (2009)

Colinet, Frédéric, Vanderick, Sylvie, Charloteaux, Benoît, Eggen, André, Gengler, Nicolas, Renaville, Bénédicte, ...

The growth hormone secretagogue receptor (GHSR) is involved in the regulation of energetic homeostasis and GH secretion. In this study, the bovine GHSR gene was mapped to BTA1 between BL26 and...

Impacts of the carbonyl group location of ester bond on interfacial properties of sugar-based surfactants: experimental and computational evidences (2009)

Razafindralambo, Hary, Blecker, Christophe, Mezdour, Samir, Deroanne, Claude, Crowet, Jean-Marc, Brasseur, Robert, ...

Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling (2008)

Adam, Benoit, Charloteaux, Benoit, Beaufays, Jerome, Vanhamme, Luc, Godfroid, Edmond, Brasseur, Robert, ...

Abstract Background Lipocalins are widely distributed in nature and are found in bacteria, plants, arthropoda and vertebra. In hematophagous arthropods, they are implicated in the successful...

Ir-LBP, an ixodes ricinus tick salivary LTB4-binding lipocalin, interferes with host neutrophil function. (2008)

Beaufays, Jerome, Adam, Benoit, Menten-Dedoyart, Catherine, Fievez, Laurence, Grosjean, Amelie, Decrem, Yves, ...

BACKGROUND: During their blood meal, ticks secrete a wide variety of proteins that can interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the...

Characterization Of A Novel Aphid Prenyltransferase Displaying Dual Geranyl/Farnesyl Diphosphate Synthase Activity (Vol 582, Pg 1928, 2008) (2008)

Vandermoten, Sophie, Charloteaux, Benoît, Santini, S., Sen, Se., Beliveau, C., Vandenbol, Micheline, ...

We report on the cDNA cloning and characterization of a novel short-chain isoprenyl diphosphate synthase from the aphid Myzus persicae. Of the three IPPS cDNAs we cloned, two yielded...

In Silico tilted properties of the 67-78 fragment of alpha-synuclein are responsible for membrane destabilization and neurotoxicity (2007)

Crowet, JM, Lins, L, Dupiereux-Fettweis, Ingrid, Elmoualij, Benaïssa, Lorin, A, Charloteaux, B, ...

alpha-Synuclein is a 140 residue protein associated with Parkinson's disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of alpha-synuclein aggregated into...

Anti-hemostatic Effects of a Serpin from the Saliva of the Tick Ixodes ricinus (2007)

Prevot, Pierre-Paul, Adam, Benoit, Zouaoui Boudjeltia, Karim, Brossard, Michel, Lins, Laurence, Cauchie, Philippe, ...

Serpins (serine protease inhibitors) are a large family of structurally related proteins found in a wide variety of organisms, including hematophagous arthropods. Protein analyses revealed that Iris,...

Anti-hemostatic Effects of a Serpin from the Saliva of the Tick Ixodes ricinus (2007)

Prevot, Pierre-Paul, Adam, Benoit, Zouaoui Boudjeltia, Karim, Brossard, Michel, Lins, Laurence, Cauchie, Philippe, ...

Serpins (serine protease inhibitors) are a large family of structurally related proteins found in a wide variety of organisms, including hematophagous arthropods. Protein analyses revealed that Iris,...

Mutational Analysis Of The Tre2 Oncogene Encoding An Inactive Rabgap (2007)

Bizimungu, C., Thomas, Annick, Brasseur, Robert, Vandenbol, Micheline

Prolactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis (2006)

Nguyen, Ngoc-Quynh-Nhu, Tabruyn, Sebastien, Lins, Laurence, Lion, Michelle, Cornet, AM, Lair, Florence, ...

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are...

The Ramachandran plots of glycine and pre-proline (2005)

Ho, Bosco K, Brasseur, Robert

Abstract Background The Ramachandran plot is a fundamental tool in the analysis of protein structures. Of the 4 basic types of Ramachandran plots, the interactions that determine the generic and...

Interaction of the 106-126 prion peptide with lipid membranes and potential implication for neurotoxicity (2005)

Dupiereux-Fettweis, Ingrid, Zorzi, Willy, Lins, L, Brasseur, Robert, Colson, Pierre, Heinen, Ernst, ...

Prion diseases are fatal neurodegenerative disorders characterized by the accumulation in the brain of an abnormally misfolded, protease-resistant, and beta-sheet rich pathogenic isoform (PrPSC) of...

Membrane topology of the Escherichia coli AmpG permease required for recycling of cell wall anhydromuropeptides and AmpC beta-lactamase induction (2005)

Chahboune, A, Decaffmeyer, M, Brasseur, Robert, Joris, Bernard

Escherichia coli, and presumably most other gram-negative bacteria, possesses an efficient protein machinery for recycling its peptidoglycan during cell growth. The major recycled peptidoglycan...

Fusogenic Alzheimer's peptide fragment A{beta} (29-42) in interaction with lipid bilayers: Secondary structure, dynamics, and specific interaction with phosphatidyl ethanolamine polar heads as revealed by solid-state NMR (2005)

Ravault, Stéphanie, Soubias, Olivier, Saurel, Olivier, Thomas, Annick, Brasseur, Robert, Milon, Alain

The interaction of the native Alzheimer’s peptide C-terminal fragment Aβ (29–42), and two mutants (G33A and G37A) with neutral lipid bilayers made of POPC and POPE in a 9:1 molar ratio was...

Functional analysis of the cell division protein FtsW of Escherichia coli (2004)

Pastoret, Soumya, Fraipont, Claudine, Den Blaauwen, Tanneke, Wolf, Benoît, Aarsman, Mirjam E. G., Piette, André, ...

Site-directed mutagenesis experiments combined with fluorescence microscopy shed light on the role of Escherichia coli FtsW, a membrane protein belonging to the SEDS family that is involved in...

Nd and Pb isotope signatures of the clay-size fraction of Labrador Sea sediments during the Holocene: Implications for the inception of the modern deep circulation pattern (2004)

Fagel, Nathalie, Hillaire-Marcel, Claude, Humblet, Marc, Brasseur, Robert, Weis, Dominique, Stevenson, Ross

Nd and Pb isotopes were measured on the fine fraction of one sediment core drilled off southern Greenland. This work aims to reconstruct the evolution of deep circulation patterns in the North...

Revisiting the Ramachandran plot: Hard-sphere repulsion, electrostatics, and H-bonding in the {alpha}-helix (2003)

Ho, Bosco K., Thomas, Annick, Brasseur, Robert

What determines the shape of the allowed regions in the Ramachandran plot? Although Ramachandran explained these regions in terms of 1–4 hard-sphere repulsions, there are discrepancies with the...

Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation (2003)

Dom, Geneviève, Shaw-Jackson, Chloë, Matis, Christelle, Bouffioux, Olivier, Picard, Jacques J., Prochiantz, Alain, ...

Several homeodomains and homeodomain‐containing proteins enter live cells through a receptor‐ and energy‐independent mechanism. Translocation through biological membranes is conferred...

Interaction Of Surfactin With Membranes: A Computational Approach (2003)

Deleu, Magali, Bouffioux, O., Razafindralambo, Hary, Paquot, Michel, Hbid, C., Thonart, Philippe, ...

Differential Functionalities of Amphiphilic Peptide Segments of the Cell-Septation Penicillin-Binding Protein 3 of Escherichia Coli (2000)

Marrec-Fairley, Monique, Piette, André, Gallet, Xavier, Brasseur, Robert, Hara, Hirochi, Fraipont, Claudine, ...

The class B M1-V577 penicillin-binding protein (PBP) 3 of Escherichia coli consists of a M1-L39 membrane anchor (bearing a cytosolic tail) that is linked via a G40-S70 intervening peptide to an...

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT) (1999)

Peelman, Frank, Vanloo, Berlinda, Perez-Mendez, Oscar, Decout, Anne, Verschelde, Jean-Luc, Labeur, Christine, ...

Lecithin cholesterol acyltransferase (LCAT) is an interfacial enzyme active on both high-density (HDL) and low-density lipoproteins (LDL). Threading alignments of LCAT with lipases suggest that...

Prediction of signal peptide functional properties: a study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants (1996)

Talmud, Philippa, Lins, Laurence, Brasseur, Robert

A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport Using...

Molecular description of biological membranes by computer aided conformational analysis / editor Robert Brasseur (1990)

Brasseur, Robert

Incluye bibliografía e índice

Antigenic Variants Of Bovine Leukemia-Virus (Blv) Are Defined By Amino-Acid Substitutions In The Nh2 Part Of The Envelope Glycoprotein-Gp51 (1989)

Portetelle, Daniel, Couez, D., Bruck, C., Kettmann, Richard, Mammerickx, M., Vandermaaten, M., ...

High-Yield Synthesis Of The Bovine Leukemia-Virus (Blv) P24 Major Internal Protein In Saccharomyces-Cerevisiae (1989)

Dumont, Jacques, Legrain, M., Portetelle, Daniel, Brasseur, Robert, Burny, A., Hilger, F.

Legislation et fiscalite internationales des hydrocarbures : exploration et production / Robert Brasseur (1975)

Brasseur, Robert

Étude géologique du massif de Suzette;--Vaucluse. (1962)

Brasseur, Robert.

Thèse--Paris.

Experimental and Conformational Analyses of Interactions between Butenafine and Lipids

Mingeot-Leclercq, Marie-Paule, Gallet, Xavier, Flore, Christel, Van Bambeke, Françoise, Peuvot, Jacques, Brasseur, Robert

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphtalenemethylamine hydrochloride) is an antifungal agent of the benzylamine class that has excellent therapeutic efficacy and a remarkably long duration...

Aminoglycoside 6′-N-Acetyltransferase Variants of the Ib Type with Altered Substrate Profile in Clinical Isolates of Enterobacter cloacae and Citrobacter freundii

Casin, Isabelle, Bordon, Florence, Bertin, Philippe, Coutrot, Anne, Podglajen, Isabelle, Brasseur, Robert, ...

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6′-N acetyltransferase type II...

Analysis of the C-Terminal Membrane Anchor Domains of Hepatitis C Virus Glycoproteins E1 and E2: toward a Topological Model

Charloteaux, Benoit, Lins, Laurence, Moereels, Henri, Brasseur, Robert

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER)...

Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation

Dom, Geneviève, Shaw-Jackson, Chloë, Matis, Christelle, Bouffioux, Olivier, Picard, Jacques J., Prochiantz, Alain, ...

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third...

Transferrin-Binding Protein B of Neisseria meningitidis: Sequence-Based Identification of the Transferrin-Binding Site Confirmed by Site-Directed Mutagenesis

Renauld-Mongénie, Geneviève, Lins, Laurence, Krell, Tino, Laffly, Laure, Mignon, Michèle, Dupuy, Monique, ...

A sequence-based prediction method was employed to identify three ligand-binding domains in transferrin-binding protein B (TbpB) of Neisseria meningitidis strain B16B6. Site-directed mutagenesis of...

Functional Analysis of the Cell Division Protein FtsW of Escherichia coli†

Pastoret, Soumya, Fraipont, Claudine, Den Blaauwen, Tanneke, Wolf, Benoît, Aarsman, Mirjam E. G., Piette, André, ...

Site-directed mutagenesis experiments combined with fluorescence microscopy shed light on the role of Escherichia coli FtsW, a membrane protein belonging to the SEDS family that is involved in...

Membrane Topology of the Escherichia coli AmpG Permease Required for Recycling of Cell Wall Anhydromuropeptides and AmpC β-Lactamase Induction

Chahboune, Aicha, Decaffmeyer, Marc, Brasseur, Robert, Joris, Bernard

Escherichia coli, and presumably most other gram-negative bacteria, possesses an efficient protein machinery for recycling its peptidoglycan during cell growth. The major recycled peptidoglycan...

The Ramachandran plots of glycine and pre-proline

Ho, Bosco K, Brasseur, Robert

TP0453, a Concealed Outer Membrane Protein of Treponema pallidum, Enhances Membrane Permeability

Hazlett, Karsten R. O., Cox, David L., Decaffmeyer, Marc, Bennett, Michael P., Desrosiers, Daniel C., La Vake, Carson J., ...

The outer membrane of Treponema pallidum, the noncultivable agent of venereal syphilis, contains a paucity of protein(s) which has yet to be definitively identified. In contrast, the outer membranes...

Exclusive Ubiquitination and Sumoylation on Overlapping Lysine Residues Mediate NF-κB Activation by the Human T-Cell Leukemia Virus Tax Oncoprotein†

Lamsoul, Isabelle, Lodewick, Julie, Lebrun, Sylvie, Brasseur, Robert, Burny, Arsène, Gaynor, Richard B., ...

The transcription factor NF-κB is critical for the induction of cancer, including adult T-cell leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the expression of its...

Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: Evidence for little recombination in the 3' end of the human gene

Dunning, Alison M., Renges, Helmut-H., Xu, Chun-Fang, Peacock, Rachel, Brasseur, Robert, Laxer, Gerald, ...

We report the identification of an A-to-G base change, in exon 29 of the apolipoprotein B (apo B) gene, that results in the substitution of serine for asparagine at residue 4311 of mature apo B100....

Experimental and Conformational Analyses of Interactions between Butenafine and Lipids

Mingeot-Leclercq, Marie-Paule, Gallet, Xavier, Flore, Christel, Van Bambeke, Françoise, Peuvot, Jacques, Brasseur, Robert

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphtalenemethylamine hydrochloride) is an antifungal agent of the benzylamine class that has excellent therapeutic efficacy and a remarkably long duration...

Aminoglycoside 6′-N-Acetyltransferase Variants of the Ib Type with Altered Substrate Profile in Clinical Isolates of Enterobacter cloacae and Citrobacter freundii

Casin, Isabelle, Bordon, Florence, Bertin, Philippe, Coutrot, Anne, Podglajen, Isabelle, Brasseur, Robert, ...

Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6′-N acetyltransferase type II...

Analysis of the C-Terminal Membrane Anchor Domains of Hepatitis C Virus Glycoproteins E1 and E2: toward a Topological Model

Charloteaux, Benoit, Lins, Laurence, Moereels, Henri, Brasseur, Robert

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER)...

Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation

Dom, Geneviève, Shaw-Jackson, Chloë, Matis, Christelle, Bouffioux, Olivier, Picard, Jacques J., Prochiantz, Alain, ...

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third...

Transferrin-Binding Protein B of Neisseria meningitidis: Sequence-Based Identification of the Transferrin-Binding Site Confirmed by Site-Directed Mutagenesis

Renauld-Mongénie, Geneviève, Lins, Laurence, Krell, Tino, Laffly, Laure, Mignon, Michèle, Dupuy, Monique, ...

A sequence-based prediction method was employed to identify three ligand-binding domains in transferrin-binding protein B (TbpB) of Neisseria meningitidis strain B16B6. Site-directed mutagenesis of...

Functional Analysis of the Cell Division Protein FtsW of Escherichia coli†

Pastoret, Soumya, Fraipont, Claudine, Den Blaauwen, Tanneke, Wolf, Benoît, Aarsman, Mirjam E. G., Piette, André, ...

Site-directed mutagenesis experiments combined with fluorescence microscopy shed light on the role of Escherichia coli FtsW, a membrane protein belonging to the SEDS family that is involved in...

Membrane Topology of the Escherichia coli AmpG Permease Required for Recycling of Cell Wall Anhydromuropeptides and AmpC β-Lactamase Induction

Chahboune, Aicha, Decaffmeyer, Marc, Brasseur, Robert, Joris, Bernard

Escherichia coli, and presumably most other gram-negative bacteria, possesses an efficient protein machinery for recycling its peptidoglycan during cell growth. The major recycled peptidoglycan...

The Ramachandran plots of glycine and pre-proline

Ho, Bosco K, Brasseur, Robert

TP0453, a Concealed Outer Membrane Protein of Treponema pallidum, Enhances Membrane Permeability

Hazlett, Karsten R. O., Cox, David L., Decaffmeyer, Marc, Bennett, Michael P., Desrosiers, Daniel C., La Vake, Carson J., ...

The outer membrane of Treponema pallidum, the noncultivable agent of venereal syphilis, contains a paucity of protein(s) which has yet to be definitively identified. In contrast, the outer membranes...

Exclusive Ubiquitination and Sumoylation on Overlapping Lysine Residues Mediate NF-κB Activation by the Human T-Cell Leukemia Virus Tax Oncoprotein†

Lamsoul, Isabelle, Lodewick, Julie, Lebrun, Sylvie, Brasseur, Robert, Burny, Arsène, Gaynor, Richard B., ...

The transcription factor NF-κB is critical for the induction of cancer, including adult T-cell leukemia, which is linked to infection by human T-cell leukemia virus type 1 and the expression of its...

Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: Evidence for little recombination in the 3' end of the human gene

Dunning, Alison M., Renges, Helmut-H., Xu, Chun-Fang, Peacock, Rachel, Brasseur, Robert, Laxer, Gerald, ...

We report the identification of an A-to-G base change, in exon 29 of the apolipoprotein B (apo B) gene, that results in the substitution of serine for asparagine at residue 4311 of mature apo B100....

Prolactin/growth hormone–derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis

Nguyen, Ngoc-Quynh-Nhu, Tabruyn, Sebastien P., Lins, Laurence, Lion, Michelle, Cornet, Anne M., Lair, Florence, ...

Angiogenesis is a crucial step in many pathologies, including tumor growth and metastasis. Here, we show that tilted peptides exert antiangiogenic activity. Tilted (or oblique-oriented) peptides are...

Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling

Adam, Benoit, Charloteaux, Benoit, Beaufays, Jerome, Vanhamme, Luc, Godfroid, Edmond, Brasseur, Robert, ...

Fusogenic Alzheimer’s peptide fragment Aβ (29–42) in interaction with lipid bilayers: Secondary structure, dynamics, and specific interaction with phosphatidyl ethanolamine polar heads as revealed by solid-state NMR

Ravault, Stéphanie, Soubias, Olivier, Saurel, Olivier, Thomas, Annick, Brasseur, Robert, Milon, Alain

The interaction of the native Alzheimer’s peptide C-terminal fragment Aβ (29–42), and two mutants (G33A and G37A) with neutral lipid bilayers made of POPC and POPE in a 9:1 molar ratio was...

Analysis of accessible surface of residues in proteins

Lins, Laurence, Thomas, Annick, Brasseur, Robert

We analyzed the total, hydrophobic, and hydrophilic accessible surfaces (ASAs) of residues from a nonredundant bank of 587 3D structure proteins. In an extended fold, residues are classified into...

Revisiting the Ramachandran plot: Hard-sphere repulsion, electrostatics, and H-bonding in the α-helix

Ho, Bosco K., Thomas, Annick, Brasseur, Robert

What determines the shape of the allowed regions in the Ramachandran plot? Although Ramachandran explained these regions in terms of 1–4 hard-sphere repulsions, there are discrepancies with the...

Ir-LBP, an Ixodes ricinus Tick Salivary LTB4-Binding Lipocalin, Interferes with Host Neutrophil Function

Beaufays, Jérôme, Adam, Benoît, Menten-Dedoyart, Catherine, Fievez, Laurence, Grosjean, Amélie, Decrem, Yves, ...

Ixodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization

Beaufays, Jérôme, Adam, Benoît, Decrem, Yves, Prévôt, Pierre-Paul, Santini, Sébastien, Brasseur, Robert, ...

Characterization of the Interactions between Fluoroquinolone Antibiotics and Lipids: a Multitechnique Approach

Bensikaddour, Hayet, Fa, Nathalie, Burton, Ingrid, Deleu, Magali, Lins, Laurence, Schanck, André, ...

Probing drug/lipid interactions at the molecular level represents an important challenge in pharmaceutical research and membrane biophysics. Previous studies showed differences in accumulation and...