Robert C. Young

Long-term follow-up of ProMACE-CytaBOM in non-Hodgkin's lymphomas (1991)

Fisher, Richard I., Longo, Dan L., DeVita, Vincent T., Hubbard, Susan M., Miller, Thomas P., Young, Robert C.

Initial results from studies with third-generation combination chemotherapy regimens for the treatment of aggressive non-Hodgkin's lymphomas (NHL) demonstrated complete remission (CR) rates higher...

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines (1989)

Lai, Gi-Ming, Ozols, Robert F., Young, Robert C., Hamilton, Thomas C.

We have studied the effect of glutathione reduction by buthionine sulf-oximine (BSO), a specific inhibitor ofλ -glutamyl cysteine synthetase, on DNA repair after cisplatin damage in an ovarian...

High-Dose Carboplatin With Diethyldithiocarbamate Chemoprotection in Treatment of Women With Relapsed Ovarian Cancer (1988)

Rothenberg, Mace L, Ostchega, Yechiam, Steinberg, Seth M., Young, Robert C., Hummel, Sherifynn, Ozols, Robert F.

Diethyldithiocarbamate (DDTC) has been found to protect the bone marrow, kidneys, and gastrointestinal tract, from the toxic effects of cisplatin and carboplatin (CBDCA) in animal mod-1 els. In an...

Deletion of 3(p14p23) in Secondary Erythroleukemia Arising in Long-Term Survivors of Small Cell Lung Cancer (1988)

Whang-Peng, Jacqueline, Lee, Elaine C., Minna, John D., Abeloff, Martin D., Bradley, Edward C., Young, Robert C., ...

Cytogenetic studies were done on the leukemia cells of two patients with small cell lung cancer (SCLC) who developed erythroleukemia (acute non-lymphocytic leukemia, French-American-British M6) after...

Electron polarization in beta decay and internal conversion (1959)

Young, Robert C., Young, Robert C.

The general theory for beta decay is developed in section 2 using a consistent normalization and phase convention for the lepton wave functions; these phases are not consistent in the literature. The...

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

Chabner, Bruce A., Young, Robert C.

The suppression of DNA synthesis in host and tumor tissues by methotrexate has been monitored in mice by determining the in vivo incorporation of tritium-labeled deoxyuridine ([3H]UdR) into DNA. The...

Cyclical Combination Chemotherapy for Advanced Breast Carcinoma

Canellos, George P., Devita, Vincent T., Gold, G. Lennard, Chabner, Bruce A., Schein, Philip S., Young, Robert C.

Twenty-five patients with advanced metastatic breast cancer were treated with the combination of methotrexate 60 mg/M2 and 5-fluorouracil 700 mg/M2 intravenously on the first and eighth days, and...

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

Chabner, Bruce A., Young, Robert C.

The suppression of DNA synthesis in host and tumor tissues by methotrexate has been monitored in mice by determining the in vivo incorporation of tritium-labeled deoxyuridine ([3H]UdR) into DNA. The...

Cyclical Combination Chemotherapy for Advanced Breast Carcinoma

Canellos, George P., Devita, Vincent T., Gold, G. Lennard, Chabner, Bruce A., Schein, Philip S., Young, Robert C.

Twenty-five patients with advanced metastatic breast cancer were treated with the combination of methotrexate 60 mg/M2 and 5-fluorouracil 700 mg/M2 intravenously on the first and eighth days, and...