Robert Edwards

Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma (2007)

Lenzi, Renato, Edwards, Robert, June, Carl, Seiden, Michael V, Garcia, Michael E, Rosenblum, Michael, ...

Abstract Background Pharmacokinetic advantages of intraperitoneal (IP) rhIL-12, tumor response to IP delivery of other cytokines as well as its potential anti-angiogenic effect provided the rationale...

Results and Frontiers in Lattice Baryon Spectroscopy (2007)

Bulava, John, Edwards, Robert, Fleming, George, Juge, K. Jimmy, Lichtl, Adam C., Mathur, Nilmani, ...

The Lattice Hadron Physics Collaboration (LHPC) baryon spectroscopy effort is reviewed. To date the LHPC has performed exploratory Lattice QCD calculations of the low-lying spectrum of Nucleon and...

Hadronic Resonances from Lattice QCD (2007)

Bulava, John, Edwards, Robert, Fleming, George, Juge, K. Jimmy, Lichtl, Adam C., Mathur, Nilmani, ...

The determination of the pattern of hadronic resonances as predicted by Quantum Chromodynamics requires the use of non-perturbative techniques. Lattice QCD has emerged as the dominant tool for such...

Exotic and higher spin mesons in the charmonium (2006)

Dudek, Jo, Edwards, Robert, Mathur, Nilmani, Richards, David

Exotic and higher spin (> 1) mesons are still not throughly investigated in lattice QCD. Using a set of derivative based operators we report our exploratory study of these mesons in charmonium...

Radiative Transitions in Charmonium (2005)

Dudek, Jozef, Edwards, Robert, Richards, David

The form factors for the radiative transitions between charmonium mesons are investigated. We employ an anisotropic lattice using a Wilson gauge action, and domain-wall fermion action. We extrapolate...

Combining Quark and Link Smearing to Improve Extended Baryon Operators (2005)

Lichtl, Adam, Basak, Subhasish, Edwards, Robert, Fleming, George T., Heller, Urs M., Morningstar, Colin, ...

The effects of Gaussian quark-field smearing and analytic stout-link smearing on the correlations of gauge-invariant extended baryon operators are studied. Gaussian quark-field smearing substantially...

A study of the N to Delta transition form factors in full QCD (2005)

Alexandrou, Constantia, Edwards, Robert, Koutsou, Giannis, Leontiou, Theodoros, Neff, Hartmut, Negele, John W., ...

The N to Delta transition form factors GM1, GE2 and GC2 are evaluated using dynamical MILC configurations and valence domain wall fermions at three values of quark mass corresponding to pion mass 606...

Clebsch-Gordan Construction of Lattice Interpolating Fields for Excited Baryons (2005)

Basak, Subhasish, Edwards, Robert, Fleming, George T., Heller, Urs M., Morningstar, Colin, Richards, David, ...

Large sets of baryon interpolating field operators are developed for use in lattice QCD studies of baryons with zero momentum. Operators are classified according to the double-valued irreducible...

Plant glutathione transferases (2002)

Dixon, David P, Lapthorn, Adrian, Edwards, Robert

Summary The soluble glutathione transferases (GSTs, EC 2.5.1.18) are encoded by a large and diverse gene family in plants, which can be divided on the basis of sequence identity into the phi, tau,...

92c/MFlops/s, Ultra-Large-Scale Neural-Network Training on a PIII Cluster (2000)

Jonathan Baxter, Robert Edwards

Artificial neural networks with millions of adjustable parameters and a similar number of training examples are a potential solution for difficult, large-scale pattern recognition problems in areas...

98c/MFlop, Ultra-Large-Scale Neural-Network Training on a PIII Cluster (2000)

Jonathan Baxter, Robert Edwards

Artificial neural networks with millions of adjustable parameters and a similar number of training examples are a potential solution for difficult, large-scale pattern recognition problems in areas...

Tuning the generalized Hybrid Monte Carlo algorithm (1995)

Kennedy, A D, Edwards, Robert, Mino, Hidetoshi, Pendleton, Brian

We discuss the analytic computation of autocorrelation functions for the generalized Hybrid Monte Carlo algorithm applied to free field theory and compare the results with numerical results for the...

Salmonella enterica Serovar Typhi Possesses a Unique Repertoire of Fimbrial Gene Sequences

Townsend, Stacy M., Kramer, Naomi E., Edwards, Robert, Baker, Stephen, Hamlin, Nancy, Simmonds, Mark, ...

Salmonella enterica serotype Typhi differs from nontyphoidal Salmonella serotypes by its strict host adaptation to humans and higher primates. Since fimbriae have been implicated in host adaptation,...

Plant glutathione transferases

Dixon, David P, Lapthorn, Adrian, Edwards, Robert

The soluble glutathione transferases (GSTs) are a large, conserved family of proteins that use the tripeptide glutathione as a cosubstrate or coenzyme. They are predominantly expressed in the cytosol...

Induction of Glutathione S-Transferases in Arabidopsis by Herbicide Safeners1

DeRidder, Ben P., Dixon, David P., Beussman, Douglas J., Edwards, Robert, Goldsbrough, Peter B.

Herbicide safeners increase herbicide tolerance in cereals but not in dicotyledenous crops. The reason(s) for this difference in safening is unknown. However, safener-induced protection in cereals is...

Stress Responses in Alfalfa (Medicago sativa L.): I. Induction of Phenylpropanoid Biosynthesis and Hydrolytic Enzymes in Elicitor-Treated Cell Suspension Cultures

Dalkin, Karen, Edwards, Robert, Edington, Brent, Dixon, Richard A.

Alfalfa (Medicago sativa L.) cell suspension cultures accumulated high concentrations of the pterocarpan phytoalexin medicarpin, reaching a maximum within 24 hours after exposure to an elicitor...

Stress Responses in Alfalfa (Medicago sativa L.) 1: V. Constitutive and Elicitor-Induced Accumulation of Isoflavonoid Conjugates in Cell Suspension Cultures

Kessmann, Helmut, Edwards, Robert, Geno, Paul W., Dixon, Richard A.

The isoflavonoid conjugates medicarpin-3-O-glucoside-6″-O-malonate (MGM), afrormosin-7-O-glucoside (AG), and afrormosin-7-O-glucoside-6″-O-malonate (AGM) were isolated and characterized from cell...

Effects of trans-Cinnamic Acid on Expression of the Bean Phenylalanine Ammonia-Lyase Gene Family 1

Mavandad, Mehrdad, Edwards, Robert, Liang, Xiaouw, Lamb, Christopher J., Dixon, Richard A.

Using DNA probes specific for the three members of the bean (Phaseolus vulgaris L.) phenylalanine ammonia-lyase (PAL) gene family, we have studied the effects of the product of the PAL reaction,...

The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes

Overbeek, Ross, Begley, Tadhg, Butler, Ralph M., Choudhuri, Jomuna V., Chuang, Han-Yu, Cohoon, Matthew, ...

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the...

Transcriptional Profiling of Mycoplasma hyopneumoniae during Heat Shock Using Microarrays†

Madsen, Melissa L., Nettleton, Dan, Thacker, Eileen L., Edwards, Robert, Minion, F. Chris

Bacterial pathogens undergo stress during host colonization and disease processes. These stresses result in changes in gene expression to compensate for potentially lethal environments developed in...

Diversification in substrate usage by glutathione synthetases from soya bean (Glycine max), wheat (Triticum aestivum) and maize (Zea mays)

Skipsey, Mark, Davis, Benjamin G., Edwards, Robert

Unlike animals which accumulate glutathione (γ-glutamyl-L-cysteinyl-glycine) alone as their major thiol antioxidant, several crops synthesize alternative forms of glutathione by varying the carboxy...

Stress-Induced Protein S-Glutathionylation in Arabidopsis1

Dixon, David P., Skipsey, Mark, Grundy, Nicholas M., Edwards, Robert

S-Glutathionylation (thiolation) is a ubiquitous redox-sensitive and reversible modification of protein cysteinyl residues that can directly regulate their activity. While well established in...

Salmonella enterica Serovar Typhi Possesses a Unique Repertoire of Fimbrial Gene Sequences

Townsend, Stacy M., Kramer, Naomi E., Edwards, Robert, Baker, Stephen, Hamlin, Nancy, Simmonds, Mark, ...

Salmonella enterica serotype Typhi differs from nontyphoidal Salmonella serotypes by its strict host adaptation to humans and higher primates. Since fimbriae have been implicated in host adaptation,...

Plant glutathione transferases

Dixon, David P, Lapthorn, Adrian, Edwards, Robert

The soluble glutathione transferases (GSTs) are a large, conserved family of proteins that use the tripeptide glutathione as a cosubstrate or coenzyme. They are predominantly expressed in the cytosol...

Induction of Glutathione S-Transferases in Arabidopsis by Herbicide Safeners1

DeRidder, Ben P., Dixon, David P., Beussman, Douglas J., Edwards, Robert, Goldsbrough, Peter B.

Herbicide safeners increase herbicide tolerance in cereals but not in dicotyledenous crops. The reason(s) for this difference in safening is unknown. However, safener-induced protection in cereals is...

Stress Responses in Alfalfa (Medicago sativa L.): I. Induction of Phenylpropanoid Biosynthesis and Hydrolytic Enzymes in Elicitor-Treated Cell Suspension Cultures

Dalkin, Karen, Edwards, Robert, Edington, Brent, Dixon, Richard A.

Alfalfa (Medicago sativa L.) cell suspension cultures accumulated high concentrations of the pterocarpan phytoalexin medicarpin, reaching a maximum within 24 hours after exposure to an elicitor...

Stress Responses in Alfalfa (Medicago sativa L.) 1: V. Constitutive and Elicitor-Induced Accumulation of Isoflavonoid Conjugates in Cell Suspension Cultures

Kessmann, Helmut, Edwards, Robert, Geno, Paul W., Dixon, Richard A.

The isoflavonoid conjugates medicarpin-3-O-glucoside-6″-O-malonate (MGM), afrormosin-7-O-glucoside (AG), and afrormosin-7-O-glucoside-6″-O-malonate (AGM) were isolated and characterized from cell...

Effects of trans-Cinnamic Acid on Expression of the Bean Phenylalanine Ammonia-Lyase Gene Family 1

Mavandad, Mehrdad, Edwards, Robert, Liang, Xiaouw, Lamb, Christopher J., Dixon, Richard A.

Using DNA probes specific for the three members of the bean (Phaseolus vulgaris L.) phenylalanine ammonia-lyase (PAL) gene family, we have studied the effects of the product of the PAL reaction,...

Stress-Induced Protein S-Glutathionylation in Arabidopsis1

Dixon, David P., Skipsey, Mark, Grundy, Nicholas M., Edwards, Robert

S-Glutathionylation (thiolation) is a ubiquitous redox-sensitive and reversible modification of protein cysteinyl residues that can directly regulate their activity. While well established in...

The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes

Overbeek, Ross, Begley, Tadhg, Butler, Ralph M., Choudhuri, Jomuna V., Chuang, Han-Yu, Cohoon, Matthew, ...

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the...

Diversification in substrate usage by glutathione synthetases from soya bean (Glycine max), wheat (Triticum aestivum) and maize (Zea mays)

Skipsey, Mark, Davis, Benjamin G., Edwards, Robert

Unlike animals which accumulate glutathione (γ-glutamyl-L-cysteinyl-glycine) alone as their major thiol antioxidant, several crops synthesize alternative forms of glutathione by varying the carboxy...

Transcriptional Profiling of Mycoplasma hyopneumoniae during Heat Shock Using Microarrays†

Madsen, Melissa L., Nettleton, Dan, Thacker, Eileen L., Edwards, Robert, Minion, F. Chris

Bacterial pathogens undergo stress during host colonization and disease processes. These stresses result in changes in gene expression to compensate for potentially lethal environments developed in...

The organization of cervical screening in general practice

Havelock, Christine, Edwards, Robert, Cuzick, Jack, Chamberlain, Jocelyn

Well organized cervical screening in general practice can have considerable clinical and financial rewards. Yet in a randomized survey of general practitioners in the United Kingdom only 43% operated...

Experimental and Computational Assessment of Conditionally Essential Genes in Escherichia coli▿

Joyce, Andrew R., Reed, Jennifer L., White, Aprilfawn, Edwards, Robert, Osterman, Andrei, Baba, Tomoya, ...

Genome-wide gene essentiality data sets are becoming available for Escherichia coli, but these data sets have yet to be analyzed in the context of a genome scale model. Here, we present an...

Whole proteome analysis of post-translational modifications: Applications of mass-spectrometry for proteogenomic annotation

Gupta, Nitin, Tanner, Stephen, Jaitly, Navdeep, Adkins, Joshua N., Lipton, Mary, Edwards, Robert, ...

While bacterial genome annotations have significantly improved in recent years, techniques for bacterial proteome annotation (including post-translational chemical modifications, signal peptides,...

Thy-1 Is a Component Common to Multiple Populations of Synaptic Vesicles

Jeng, Chung-Jiuan, McCarroll, Steven A., Martin, Thomas F. J., Floor, Erik, Adams, James, Krantz, David, ...

Thy-1, a glycosylphosphatidylinositol-linked integral membrane protein of the immunoglobulin superfamily, is a component of both large dense-core and small clear vesicles in PC12 cells. A majority of...

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

Brazier-Hicks, Melissa, Offen, Wendy A., Gershater, Markus C., Revett, Timothy J., Lim, Eng-Kiat, Bowles, Dianna J., ...

The glucosylation of pollutant and pesticide metabolites in plants controls their bioactivity and the formation of subsequent chemical residues. The model plant Arabidopsis thaliana contains >100...

Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

Chen, Peng-Chieh, Kuraguchi, Mari, Velasquez, John, Wang, Yuxun, Yang, Kan, Edwards, Robert, ...

DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To...