Bacterial artificial chromosomes improve recombinant protein production in mammalian cells (2009)
Blaas, Leander, Musteanu, Monica, Eferl, Robert, Bauer, Anton, Casanova, Emilio
Abstract Background The development of appropriate expression vectors for large scale protein production constitutes a critical step in recombinant protein production. The use of conventional...
Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease (2008)
Zenz, Rainer, Eferl, Robert, Scheinecker, Clemens, Redlich, Kurt, Smolen, Josef, Schonthaler, Helia B, ...
Abstract Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in...
Distinct functions of junD in cardiac hypertrophy and heart failure (2005)
Ricci, Romeo, Eriksson, Urs, Oudit, Gavin Y., Eferl, Robert, Akhmedov, Alexander, Sumara, Izabela, ...
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical...
Schausberger, Elisabeth, Eferl, Robert, Parzefall, Wolfram, Chabikovsky, Monica, Breit, Paul, Wagner, Erwin F., ...
For growth stimulation of liver cells by hepatocyte growth factor (HGF) or transforming growth factor α (TGFα) via receptor tyrosine kinases, c-fos/c-jun has been considered a point of intersection...
Schausberger, Elisabeth, Eferl, Robert, Parzefall, Wolfram, Chabikovsky, Monica, Breit, Paul, Wagner, Erwin F., ...
For growth stimulation of liver cells by hepatocyte growth factor (HGF) or transforming growth factor α (TGFα) via receptor tyrosine kinases, c-fos/c-jun has been considered a point of...
Schausberger, Elisabeth, Eferl, Robert, Parzefall, Wolfram, Chabicovsky, Monika, Breit, Paul, Wagner, Erwin F., ...
Schausberger, Elisabeth, Eferl, Robert, Parzefall, Wolfram, Chabikovsky, Monica, Breit, Paul, Wagner, Erwin F., ...
For growth stimulation of liver cells by hepatocyte growth factor (HGF) or transforming growth factor α (TGFα) via receptor tyrosine kinases, c-fos/c-jun has been considered a point of intersection...
The Fos-related antigen Fra-1 is an activator of bone matrix formation
Eferl, Robert, Hoebertz, Astrid, Schilling, Arndt F, Rath, Martina, Karreth, Florian, Kenner, Lukas, ...
Ectopic expression of the transcription factor Fra-1 in transgenic mice leads to osteosclerosis, a bone disorder characterized by increased bone mass. The molecular basis for this phenotype is...
Distinct functions of junD in cardiac hypertrophy and heart failure
Ricci, Romeo, Eriksson, Urs, Oudit, Gavin Y., Eferl, Robert, Akhmedov, Alexander, Sumara, Izabela, ...
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical...
The Fos-related antigen Fra-1 is an activator of bone matrix formation
Eferl, Robert, Hoebertz, Astrid, Schilling, Arndt F, Rath, Martina, Karreth, Florian, Kenner, Lukas, ...
Ectopic expression of the transcription factor Fra-1 in transgenic mice leads to osteosclerosis, a bone disorder characterized by increased bone mass. The molecular basis for this phenotype is...
Distinct functions of junD in cardiac hypertrophy and heart failure
Ricci, Romeo, Eriksson, Urs, Oudit, Gavin Y., Eferl, Robert, Akhmedov, Alexander, Sumara, Izabela, ...
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical...
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Stepniak, Ewa, Ricci, Romeo, Eferl, Robert, Sumara, Grzegorz, Sumara, Izabela, Rath, Martina, ...
The AP-1 transcription factor c-Jun is a key regulator of hepatocyte proliferation. Mice lacking c-Jun in the liver (c-jun Δli*) display impaired liver regeneration after partial hepatectomy (PH)....
Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
Kenner, Lukas, Hoebertz, Astrid, Beil, Timo, Keon, Niamh, Karreth, Florian, Eferl, Robert, ...
Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunBΔ/Δ mice are born viable, but develop severe low turnover osteopenia caused by apparent...
Functions of c-Jun in Liver and Heart Development
Eferl, Robert, Sibilia, Maria, Hilberg, Frank, Fuchsbichler, Andrea, Kufferath, Iris, Guertl, Barbara, ...
Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a...
Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease
Zenz, Rainer, Eferl, Robert, Scheinecker, Clemens, Redlich, Kurt, Smolen, Josef, Schonthaler, Helia B, ...
Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in mouse...
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
Eferl, Robert, Hasselblatt, Peter, Rath, Martina, Popper, Helmut, Zenz, Rainer, Komnenovic, Vukoslav, ...
Studies using genetically modified mice have revealed fundamental functions of the transcription factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role of the...