Molecular and clinical advances in anticancer drug resistance / edited by Robert F. Ozols (1991)
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O'Dwyer, Peter J., Hudes, GaryR., Colofiore, Joseph, Walczak, Judy, Hoffman, John, LaCreta, Frank P., ...
Preclinical and Clinical studies demonstrate that the selective antitumor activity of fluroruracil (5-FU) is enhanced by agents which perturb certain interacellular nucleotide pools. We previously...
Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines (1989)
Lai, Gi-Ming, Ozols, Robert F., Young, Robert C., Hamilton, Thomas C.
We have studied the effect of glutathione reduction by buthionine sulf-oximine (BSO), a specific inhibitor ofλ -glutamyl cysteine synthetase, on DNA repair after cisplatin damage in an ovarian...
Rothenberg, Mace L, Ostchega, Yechiam, Steinberg, Seth M., Young, Robert C., Hummel, Sherifynn, Ozols, Robert F.
Diethyldithiocarbamate (DDTC) has been found to protect the bone marrow, kidneys, and gastrointestinal tract, from the toxic effects of cisplatin and carboplatin (CBDCA) in animal mod-1 els. In an...
The measurement of cisplatin-DNA adduct levels in testicular cancer patients (1988)
Reed, Eddie, Ozols, Robert F., Tarone, Robert, Yuspa, Stuart H., Poirier, Miriam C.
Seventeen patients with ‘poor prognosis’ non-seminomatous testicular cancer were monitored for formation of intrastrand bidentate N7-d(ApG)- and N7-d(GpG)- diammineplatinum adducts in peripheral...
Godwin, Andrew K., Vanderveer, Lisa, Schultz, David C., Lynch, Henry T., Altomare, Deborah A., Buetow, Kenneth H., ...
Linkage analysis in familial breast and ovarian cancer and studies of allelic deletion in sporadic ovarian tumors have identified a region on chromosome 17q containing a candidate tumor-suppressor...