Integrative modeling of transcriptional regulation in response to antirheumatic therapy (2009)
Hecker, Michael, Goertsches, Robert, Engelmann, Robby, Thiesen, Hans-Juergen, Guthke, Reinhard
Abstract Background The investigation of gene regulatory networks is an important issue in molecular systems biology and significant progress has been made by combining different types of biological...
mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis (2008)
Yu, Xinhua, Koczan, Dirk, Sulonen, Anna-Maija, Akkad, Denis A., Kroner, Antje, Comabella, Manuel, ...
Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order...
Genetic factors in the autoimmune disease multiple sclerosis (2007)
Die Multiple Sklerose (MS) ist eine entzündliche demyelinisierende Erkrankung, die auf das zentrale Nervensystem (ZNS) begrenzt ist. Diese Krankheit, die wahrscheinlich eine autoimmune Genese hat,...
Marquès-Bonet, Tomàs, Lao, Oscar, Goertsches, Robert, Comabella, Manuel, Montalban, Xavier, Navarro, Arcadi
Summary: Whole genome scans analyze large sets of genetic markers, mainly single nucleotide polymorphisms, over the entire genome in order to find variants and regions associated with complex traits...