Operaña, Theresa N., Nguyen, Nghia, Chen, Shujuan, Beaton, Deirdre, Tukey, Robert H.
The human CYP1A1 gene is regulated by the aryl hydrocarbon receptor (AhR), and induction of CYP1A1 is known to play an important role in xenobiotic metabolism. To examine the regulation of human...
Operaña, Theresa N., Nguyen, Nghia, Chen, Shujuan, Beaton, Deirdre, Tukey, Robert H.
The human CYP1A1 gene is regulated by the aryl hydrocarbon receptor (AhR) and induction of CYP1A1 is known to play an important role in xenobiotic metabolism. To examine the regulation of human...
The Role of Protein Kinase C in Regulation of TCDD-Mediated CYP1A1 Gene Expression (2005)
Machemer, Daniel E. W., Tukey, Robert H.
Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Protein kinase C (PKC) has been implicated in...
The Role of Protein Kinase C in Regulation of TCDD-Mediated CYP1A1 Gene Expression (2005)
Machemer, Daniel E.W., Tukey, Robert H.
Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the Ah receptor. Protein kinase C (PKC) has been implicated in the regulation of...
Jessica A. Bonzo, Shujuan Chen, Alema Galijatovic, Robert H. Tukey
We show here that arsenite (As 3 � ) elicits multiple effects on gene control, such as the interruption of cell cycle control by initiating G 2/M arrest as well as inhibiting the aryl hydrocarbon...
Yueh, Mei-Fei, Nguyen, Nghia, Famourzadeh, Maryam, Strassburg, Christian P., Oda, Yoshimitsu, Guengerich, F.Peter, ...
The importance of environmental and dietary arylamines, and heterocyclic amines in the etiology of human cancer is of growing interest. These pre-carcinogens are known to undergo bioactivation by...
Nowell, Susan A., Massengill, Joyce S., Williams, Suzanne, Radominska-Pandya, Anna, Tephly, Thomas R., Cheng, Ziqiang, ...
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a heterocyclic aromatic amine found in cooked meats and dietary exposure to PhIP has been implicated in the etiology of colon cancer in...
Shimada, Tsutomu, Gillam, Elizabeth M.J., Sandhu, Punam, Guo, Zuyu, Tukey, Robert H., Guengerich, F.Peter
Bacterial assays were used to examine the activation of 14 known procarcinogens by cytochrome P450 (P450) enzymest†. Human P450s 1A1, 1A2 and 3A4 were expressed in Escherichia coil with slight...
Xie, Wen, Yeuh, Mei-Fei, Radominska-Pandya, Anna, Saini, Simrat P. S., Negishi, Yoichi, Bottroff, Bobbie Sue, ...
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the...
Xie, Wen, Yeuh, Mei-Fei, Radominska-Pandya, Anna, Saini, Simrat P. S., Negishi, Yoichi, Bottroff, Bobbie Sue, ...
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the...