Gains and Optimal Design in Signaling Pathways (2009)
Madalena Chaves, Eduardo D. Sontag, Robert J. Dinerstein
Abstract — Signal amplification and other input-to-output properties of signaling cascades are characterized by the H∞ gain in the case of linear systems, or by the L 2 induced norm in the...
Optimal Length and Signal Amplification in Weakly Activated Signal Transduction Cascades (2004)
Madalena Chaves, Eduardo D. Sontag, Robert J. Dinerstein
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system provide natural measures for the propagation of...
Optimal length and signal amplification in weakly activated signal transduction cascades (2003)
Chaves, Madalena, Sontag, Eduardo D., Dinerstein, Robert J.
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of...