Robert J. Owen

Amoxicillin therapy of poultry flocks: effect upon the selection of amoxicillin-resistant commensal Campylobacter spp. (2009)

Elviss, Nicola C., Williams, Lisa K., Jørgensen, Frieda, Chisholm, Stephanie A., Lawson, Andrew J., Swift, Craig, ...

Background The aim of this study was to investigate the effect of amoxicillin therapy of poultry flocks upon the persistence of commensal Campylobacter spp. and the incidence of antibiotic...

A novel real-time PCR assay for the detection of Helicobacter pullorum-like organisms in chicken products (2008)

Ana González, Patricia Piqueres, Yolanda Moreno, Irene Cañigral, Robert J. Owen, Javier Hernández, ...

A novel real-time PCR assay was developed for the direct detection in food of Helicobacter pullorum-like bacteria, which are occasionally associated with human enteric disease. Experiments using...

Horizontal versus familial transmission of Helicobacter pylori (2008)

Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...

Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...

Horizontal versus familial transmission of Helicobacter pylori (2008)

Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...

Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...

Horizontal versus Familial Transmission of Helicobacter pylori (2008)

Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...

Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...

Host-pathogen interactions in campylobacter infections: the host perspective (2008)

Janssen, Riny, Krogfelt, Karen A., Cawthraw, Shaun A., Pelt, Wilfrid Van, Wagenaar, J.A., Owen, Robert J.

Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide (3). The incidence of human campylobacteriosis increased exponentially during the last decade of the 20th century (183),...

A novel real-time PCR assay for the detection of Helicobacter pullorum-like organisms in chicken products (2008)

González, Ana, Piqueres, Patricia, Moreno, Yolanda, Cañigral, Irene, Owen, Robert J., Hernández, Javier, ...

A novel real-time PCR assay was developed for the direct detection in food of Helicobacter pullorum-like bacteria, which are occasionally associated with human enteric disease. Experiments using...

Real-time PCR detection and frequency of 16S rDNA mutations associated with resistance and reduced susceptibility to tetracycline in Helicobacter pylori from England and Wales (2005)

Lawson, Andrew J., Elviss, Nicola C., Owen, Robert J.

Objectives: To investigate the occurrence of 16S rDNA mutations associated with resistance or reduced susceptibility to tetracycline in Helicobacter pylori isolated in England and Wales, and to...

Real-time PCR detection and frequency of 16S rDNA mutations associated with resistance and reduced susceptibility to tetracycline in Helicobacter pylori from England and Wales (2005)

Lawson, Andrew J., Elviss, Nicola C., Owen, Robert J.

Objectives: To investigate the occurrence of 16S rDNA mutations associated with resistance or reduced susceptibility to tetracycline in Helicobacter pylori isolated in England and Wales, and to...

Helicobacter pylori antibiotic resistance patterns and genotypes in adult dyspeptic patients from a regional population in North Wales (2004)

Elviss, Nicola C., Owen, Robert J., Xerry, Jacqueline, Walker, A. Mark, Davies, Kenneth

Objective: Surveillance data on Helicobacter pylori antibiotic susceptibilities in Wales are limited, despite resistance being a key factor in treatment failure. A single-centre survey was undertaken...

Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance (2003)

Chisholm, Stephanie A., Owen, Robert J.

Metronidazole resistance in Helicobacter pylori reportedly occurs by mutational inactivation of the oxygen-insensitive nitroreductase gene rdxA. Nucleotide sequences of rdxA were determined in a set...

Mutations in Helicobacter pylorirdxA gene sequences may not contribute to metronidazole resistance (2003)

Chisholm, Stephanie A., Owen, Robert J.

Metronidazole resistance in Helicobacter pylori reportedly occurs by mutational inactivation of the oxygen-insensitive nitroreductase gene rdxA. Nucleotide sequences of rdxA were determined in a set...

Mutations in Helicobacter pylorirdxA gene sequences may not contribute to metronidazole resistance (2003)

Chisholm, Stephanie A., Owen, Robert J.

Metronidazole resistance in Helicobacter pylori reportedly occurs by mutational inactivation of the oxygen-insensitive nitroreductase gene rdxA. Nucleotide sequences of rdxA were determined in a set...

PCR-Based Diagnosis of Helicobacter pylori Infection and Real-Time Determination of Clarithromycin Resistance Directly from Human Gastric Biopsy Samples

Chisholm, Stephanie A., Owen, Robert J., Teare, E. Louise, Saverymuttu, Seth

A novel PCR detection assay that amplifies the Helicobacter pylori-specific vacuolating cytotoxin gene (vacA) and thus enables rapid diagnosis of infection is described. Additionally, a real-time...

Differentiation of Metronidazole-Sensitive and -Resistant Clinical Isolates of Helicobacter pylori by Immunoblotting with Antisera to the RdxA Protein

Latham, Stephanie R., Owen, Robert J., Elviss, Nicola C., Labigne, Agnès, Jenks, Peter J.

Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem, and the development of rapid, reliable methods for detecting resistance would greatly improve the selection of...

Development of a Scheme for Genotyping Helicobacter pylori Based on Allelic Variation in Urease Subunit Genes

Owen, Robert J., Slater, Eleanor R., Xerry, Jacqueline, Peters, Tansy M., Teare, E. Louise, Grant, Andrew

Helicobacter pylori urease subunit genes in 383 isolates from 10 countries were investigated by PCR-restriction fragment length polymorphism (HaeIII) analysis. Eighty-two different ureAB profiles...

Identification of cagA Tyrosine Phosphorylation DNA Motifs in Helicobacter pylori Isolates from Peptic Ulcer Patients by Novel PCR-Restriction Fragment Length Polymorphism and Real-Time Fluorescence PCR Assays

Owen, Robert J., Sharp, Sally I., Chisholm, Stephanie A., Rijpkema, Sjoerd

Cag pathogenicity island-containing Helicobacter pylori (type I) induces signal transduction pathways resulting in tyrosine phosphorylation of proteins adjacent to the site of bacterial adhesion on...

PCR-Based Diagnosis of Helicobacter pylori Infection and Real-Time Determination of Clarithromycin Resistance Directly from Human Gastric Biopsy Samples

Chisholm, Stephanie A., Owen, Robert J., Teare, E. Louise, Saverymuttu, Seth

A novel PCR detection assay that amplifies the Helicobacter pylori-specific vacuolating cytotoxin gene (vacA) and thus enables rapid diagnosis of infection is described. Additionally, a real-time...

Differentiation of Metronidazole-Sensitive and -Resistant Clinical Isolates of Helicobacter pylori by Immunoblotting with Antisera to the RdxA Protein

Latham, Stephanie R., Owen, Robert J., Elviss, Nicola C., Labigne, Agnès, Jenks, Peter J.

Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem, and the development of rapid, reliable methods for detecting resistance would greatly improve the selection of...

Development of a Scheme for Genotyping Helicobacter pylori Based on Allelic Variation in Urease Subunit Genes

Owen, Robert J., Slater, Eleanor R., Xerry, Jacqueline, Peters, Tansy M., Teare, E. Louise, Grant, Andrew

Helicobacter pylori urease subunit genes in 383 isolates from 10 countries were investigated by PCR-restriction fragment length polymorphism (HaeIII) analysis. Eighty-two different ureAB profiles...

Identification of cagA Tyrosine Phosphorylation DNA Motifs in Helicobacter pylori Isolates from Peptic Ulcer Patients by Novel PCR-Restriction Fragment Length Polymorphism and Real-Time Fluorescence PCR Assays

Owen, Robert J., Sharp, Sally I., Chisholm, Stephanie A., Rijpkema, Sjoerd

Cag pathogenicity island-containing Helicobacter pylori (type I) induces signal transduction pathways resulting in tyrosine phosphorylation of proteins adjacent to the site of bacterial adhesion on...

Horizontal versus Familial Transmission of Helicobacter pylori

Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...

Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...

Host-Pathogen Interactions in Campylobacter Infections: the Host Perspective

Janssen, Riny, Krogfelt, Karen A., Cawthraw, Shaun A., Van Pelt, Wilfrid, Wagenaar, Jaap A., Owen, Robert J.

Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide. This study was aimed at summarizing the current understanding of host mechanisms involved in the defense against...