Robert J. Soiffer

Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation (2002)

Molrine, Deborah, Antin, Joseph H., Guinan, Eva C., Soiffer, Robert J., MacDonald, Kristin, Malley, Richard, ...

Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk for infections with Streptococcus pneumoniae and have long-lasting, impaired antibody responses to pneumococcal...

CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia

Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...

This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...

ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction

Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...

An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...

Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction

Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...

The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

Hodi, F. Stephen, Mihm, Martin C., Soiffer, Robert J., Haluska, Frank G., Butler, Marcus, Seiden, Michael V., ...

A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure...

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia

Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...

The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission

Miklos, David B., Kim, Haesook T., Miller, Katherine H., Guo, Luxuan, Zorn, Emmanuel, Lee, Stephanie J., ...

Minor histocompatibility antigens (mHAs) are known targets of donor T cells after allogeneic hematopoietic stem cell transplantation (HSCT). In contrast, B-cell responses to mHAs have not been...

Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors

Miklos, David B., Kim, Haesook T., Zorn, Emmanuel, Hochberg, Ephraim P., Guo, Luxuan, Mattes-Ritz, Alex, ...

Minor histocompatibility antigens (mHAs) recognized by donor T cells play a central role as immunologic targets of graft-versus-host disease (GVHD) and graft versus leukemia after allogeneic...

Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response after Allogeneic Stem Cell Transplantation

Zorn, Emmanuel, Miklos, David B., Floyd, Blair H., Mattes-Ritz, Alex, Guo, Luxuan, Soiffer, Robert J., ...

We examined the immune response to DBY, a model H-Y minor histocompatibility antigen (mHA) in a male patient with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell...

CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia

Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...

This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...

ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction

Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...

An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...

Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction

Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, ...

The identification of antigens associated with tumor destruction is a major goal of cancer immunology. Vaccination with irradiated tumor cells engineered to secrete granulocyte–macrophage colony...

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

Hodi, F. Stephen, Mihm, Martin C., Soiffer, Robert J., Haluska, Frank G., Butler, Marcus, Seiden, Michael V., ...

A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure...

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia

Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...

The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Gribben, John G., Zahrieh, David, Stephans, Katherine, Bartlett-Pandite, Lini, Alyea, Edwin P., Fisher, David C., ...

We report here on the long-term follow-up on 162 patients with high-risk chronic lymphocytic leukemia (CLL) who have undergone hematopoietic stem cell transplantation (SCT) at a single center from...

Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease

Zorn, Emmanuel, Kim, Haesook T., Lee, Stephanie J., Floyd, Blair H., Litsa, Despina, Arumugarajah, Sankari, ...

Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation but the immune mechanisms leading to the diverse clinical manifestations of...

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

Zorn, Emmanuel, Nelson, Erik A., Mohseni, Mehrdad, Porcheray, Fabrice, Kim, Haesook, Litsa, Despina, ...

IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3+ regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs. In vitro, IL-2 selectively up-regulated...

Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

Bellucci, Roberto, Oertelt, Sabine, Gallagher, Meagan, Li, Sigui, Zorn, Emmanuel, Weller, Edie, ...

A unique characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC) is the presence of high-titer and extremely specific autoantibodies to the E2 component of the pyruvate...

Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response after Allogeneic Stem Cell Transplantation

Zorn, Emmanuel, Miklos, David B., Floyd, Blair H., Mattes-Ritz, Alex, Guo, Luxuan, Soiffer, Robert J., ...

We examined the immune response to DBY, a model H-Y minor histocompatibility antigen (mHA) in a male patient with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell...

Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation

Cutler, Corey, Li, Shuli, Ho, Vincent T., Koreth, John, Alyea, Edwin, Soiffer, Robert J., ...

We assessed the combination of sirolimus and tacrolimus without methotrexate after myeloablative allogeneic stem cell transplantation from 53 matched related donors (MRDs) and 30 unrelated donors...

Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation

Armand, Philippe, Kim, Haesook T., Cutler, Corey S., Ho, Vincent T., Koreth, John, Alyea, Edwin P., ...

Iron overload could be a significant contributor to treatment-related mortality (TRM) for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT). We studied...

Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis

Marty, Francisco M., Bryar, Julie, Browne, Sarah K., Schwarzberg, Talya, Ho, Vincent T., Bassett, Ingrid V., ...

Sirolimus-based immunosuppressive regimens in organ transplantation have been associated with a lower than expected incidence of cytomegalovirus (CMV) disease. Whether sirolimus has a similar effect...