Robert Kumsta

Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion (2009)

Wüst, Stefan, Kumsta, Robert, Treutlein, Jens, Frank, Josef, Entringer, Sonja, Schulze, Thomas G., ...

Objective: A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related...

Prenatal psychosocial stress exposure is associated with subsequent working memory performance in young women (2009)

Entringer, Sonja, Buss, Claudia, Kumsta, Robert, Hellhammer, Dirk, Wadhwa, Pathik, Wüst, Stefan

The aim of the present study was to examine the association between prenatal psychosocial stress exposure and subsequent prefrontal cortex-dependent working memory performance in human adults....

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance (2009)

Kumsta, Robert, Moser, Dirk, Streit, Fabian, Koper, Jan-Willem, Meyer, Jobst, Wüst, Stefan

Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with the etiology of major depression. One of the factors underlying altered glucocorticoid signaling might be...

Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults (2009)

Entringer, Sonja, Kumsta, Robert, Wadhwa, Pathik, Hellhammer, Dirk, Wüst, Stefan

Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic-pituitary-adrenal...

Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site (2009)

Moser, Dirk, Ekawardhani, Savira, Kumsta, Robert, Palmason, Haukur, Bock, Christoph, Athanassiadou, Zoi, ...

The human potassium-chloride co-transporter 3 (KCC3, SLC12A6) is involved in cell proliferation and in electro-neutral movement of ions across the cell membrane. The gene (SLC12A6) is located on...

Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay (2009)

Stevens, Suzanne E., Kumsta, Robert, Kreppner, Jana M., Brookes, Keeley J., Rutter, Michael

Covariance between psychological and endocrine responses to pharmacological challenge and psychosocial stress: a question of timing (2008)

Schlotz, Wolff, Kumsta, Robert, Layes, Irmgard, Entringer, Sonja, Jones, Alexander, Wüst, Stefan

Objective: To test if the covariance of hypothalamus-pituitary-adrenal (HPA) axis and subjective-psychological responses to stress is dependent on different dynamics of these systems. Although stress...

Influence of prenatal psychosocial stress on cytokine production in adult women (2008)

Entringer, Sonja, Kumsta, Robert, Nelson, Edward L., Hellhammer, Dirk H., Wadhwa, Pathik D., Wüst, Stefan

The aim of the present study was to determine the association between prenatal stress and immune function in human adults. Peripheral blood mononuclear cells (PBMCs) from 34 healthy young women whose...

Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site (2008)

Moser, Dirk, Ekawardhani, Savira, Kumsta, Robert, Palmason, Haukur, Bock, Christoph, Athanassiadou, Zoi, ...

The human potassium-chloride co-transporter 3 (KCC3, SLC12A6) is involved in cell proliferation and in electro-neutral movement of ions across the cell membrane. The gene (SLC12A6) is located on...

G72 and its association with major depression and neuroticism in large population-based groups from Germany (2008)

Rietschel, Marcella, Beckmann, Lars, Strohmeier, Jana, Georgi, Alexander, Karpushova, Anna, Schirmbeck, Frederike, ...

OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be...

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance (2008)

Kumsta, Robert, Moser, Dirk, Streit, Fabian, Koper, Jan-Willem, Meyer, Jobst, Wüst, Stefan

Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis has been associated with the etiology of major depression. One of the factors underlying altered glucocorticoid signaling might be...

Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes (2008)

Kumsta, Robert, Entringer, Sonja, Koper, Jan-Willem, Van Rossum, Elisabeth, Hellhammer, Dirk, Wüst, Stefan

A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as...

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress (2007)

Kumsta, Robert, Entringer, Sonja, Koper, Jan Willem, Hellhammer, Dirk H., Wüst, Stefan

Background: Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors...

Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels (2007)

Kumsta, Robert, Entringer, Sonja, Hellhammer, Dirk H., Wüst, Stefan

The hypothalamus–pituitary–adrenal (HPA) axis is vital for an organisms’ response to physiological and psychological stress. Cortisol, secreted upon activation of the HPA axis, impacts on...

Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels (2007)

Kumsta, Robert, Entringer, Sonja, Hellhammer, Dirk H., Wüst, Stefan

The hypothalamus–pituitary–adrenal (HPA) axis is vital for an organisms’ response to physiological and psychological stress. Cortisol, secreted upon activation of the HPA axis, impacts on...

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress (2007)

Kumsta, Robert, Entringer, Sonja, Koper, Jan W., Hellhammer, Dirk H., Wüst, Stefan

Background Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors...

Prenatal psychosocial stress exposure is associated with insulin resistance in young adults (2007)

Entringer, Sonja, Wüst, Stefan, Kumsta, Robert, Layes, Irmgard, Nelson, Edward, Hellhammer, Dirk, ...

Context: Epidemiological studies across the world have reported strong associations between markers of an individual’s birth phenotype (e.g., birth weight) and subsequent risk for type 2 diabetes...

Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses (2007)

Kumsta, Robert, Entringer, Sonja, Koper, Jan Willem, Van Rossum, Elisabeth, Hellhammer, Dirk H., Wüst, Stefan

Background: Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors...

Association of a polymorphism in the H6PD gene and basal cortisol secretion, body fat mass and leptin level (Assoziation eines Polymorphismus im H6PD Gen mit basaler Cortisolsekretion, Fettmasse und Leptinwerten) (2005)

Bellingrath, Silja, Kumsta, Robert, Meyer, Jobst, Moser, Dirk, Federenko, Ilona S., Hellhammer, Dirk H., ...

The hypothalamus-pituitary-adrenal (HPA) axix is vital for an organism's response to physical or psychosocial stimulation. Chronic dysregulation of HPA axis activity is related to several psychiatric...

A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity (2004)

Wüst, Stefan, Federenko, Ilona S., Koper, Jan Willem, Kumsta, Robert, Entringer, Sonja, ...

From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the...

A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity (2004)

Wüst, Stefan, Federenko, Ilona S., Koper, Jan Willem, Kumsta, Robert, Entringer, Sonja, ...

From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the...

Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocrticol responses to psychosocial stress (2004)

Wüst, Stephan, Federenko, Ilona S., Koper, Jan W., Kumsta, Robert, Hellhammer, Dirk H.

Chronic dysregulation of hypothalamus-pituitary-adrenal axis activity is related to several stress-related disorders. Evidence suggests that polymorphisms in the glucocorticoid receptor (GR) gene may...

Free cortisol awakening responses are influenced by awakening time (2004)

Federenko, Ilona, Wüst, Stefan, Hellhammer, Dirk H., Dechoux, Ralph, Kumsta, Robert, Kirschbaum, Clemens

Psychobiological investigations on the hypothalamus–pituitary–adrenal (HPA) axis depend on markers that adequately describe the activity of this system. There is evidence that the free cortisol...

Free cortisol awakening responses are influenced by awakening time (2004)

Federenko, Ilona, Wüst, Stefan, Hellhammer, Dirk H., Dechoux, Ralf, Kumsta, Robert, Kirschbaum, Clemens

Psychobiological investigations on the hypothalamus–pituitary–adrenal (HPA) axis depend on markers that adequately describe the activity of this system. There is evidence that the free cortisol...

Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress (2004)

Wüst, Stefan, Federenko, Ilona S., Koper, Jan Willem, Kumsta, Robert, Hellhammer, Dirk H.

Chronic dysregulation of hypothalamus-pituitary-adrenal axis activity is related to several stress-related disorders. Evidence suggests that polymorphisms in the glucocorticoid receptor (GR) gene may...