Robert N. Muller

Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke (2010)

Jin, Albert Y, Tuor, Ursula I, Rushforth, David, Kaur, Jaspreet, Muller, Robert N, Petterson, Jodie, ...

Abstract Background The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of...

Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease (2008)

Larbanoix, Lionel ; JFA; CORA, Burtea, Carmen, Laurent, Sophie, Van Leuven, Freddy; U0013945 ;, Toubeau, Gérard, Elst, Luce Vander, ...

Amyloid plaques (AP) represent one of the main molecular hallmarks of Alzheimer's disease (AD). In order to develop new AP-specific contrast agents for AD molecular imaging, the phage display...

Molecular imaging of {alpha}v{beta}3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA (2008)

Burtea, Carmen ; JFA; CORA, Laurent, Sophie, Murariu, Oltea, Rattat, Dirk; U0042866 ;, Toubeau, Gérard, Verbruggen, Alfons; U0018649 ;, ...

AIMS: The integrin alpha(v)beta(3) is highly expressed in atherosclerotic plaques by medial and intimal smooth muscle cells and by endothelial cells of angiogenic microvessels. In this study, we have...

Molecular imaging of {alpha}v{beta}3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA (2008)

Burtea, Carmen, Laurent, Sophie, Murariu, Oltea, Rattat, Dirk, Toubeau, Gérard, Verbruggen, Alfons, ...

Aims The integrin αvβ3 is highly expressed in atherosclerotic plaques by medial and intimal smooth muscle cells and by endothelial cells of angiogenic microvessels. In this study, we have assessed...

Bis(phenylethylamide) derivatives of Gd-DTPA as potential receptor-specific MRI contrast agents (2007)

Laurent, Sophie ; JFA;, Parac-Vogt, Tatjana N.; U0037070 ; CORA, Kimpe, Kristof, Thirifays, Coralie, Binnemans, Koen; U0007851 ;, Muller, Robert N., ...

DTPA-bis(amide) derivatives bearing phenyl, phenol or catechol groups that mimic side chains of naturally occurring amino acids, such as phenylatanine, tyrosine or dopamine, were synthesized and...

New ultrasmall iron-oxide nanoparticles with high magnetisation as potential T1-MRI contrast agents for Molecular Imaging (2006)

Taboada, Elena, Rodriguez, Elisenda, Roig, Anna, Oro, Judit, Roch, Alain, Muller, Robert N.

Here we report on the synthesis of very small gamma-Fe2O3 nanoparticles (5 nm) presenting very narrow particle size distribution and exceptionally high saturation magnetisation. The synthesis has...

Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity (2006)

Parac-Vogt, Tatjana N; U0037070 JFA; CORA, Vander Elst, Luce, Kimpe, Kristof, Laurent, Sophie, Burtéa, Carmen, Chen, Feng; U0039628 ;, ...

A high-molecular weight tetrametallic supramolecular complex [(Ln-DTPA-phen)3Fe]- (Ln = Gd, Eu, La) has been obtained upon self-assembly around one iron(II) ion of three 1,10-phenantroline-based...

Paramagnetic liposomes containing amphiphilic bisamide derivatives of Gd-DTPA with aromatic side chain groups as possible contrast agents for magnetic resonance imaging (2006)

Parac-Vogt, Tatjana N.; U0037070 JFA; CORA, Kimpe, Kristof, Laurent, Sophie, Pierart, Corinne, Vander Elst, Luce, Muller, Robert N., ...

Three amphiphilic DTPA bisamide derivatives containing long-chain phenylalanine esters (with 14, 16 and 18 carbon atoms in the alkyl chain) were synthesized and their corresponding gadolinium(III)...

The vascular flora of an old-growth mixed mesophytic forest in southeastern Kentucky (2005)

Ryan W. McEwan, Robert D. Paratley, Robert N. Muller, Cynthia L. Riccardi

Synthesis, characterization, and pharmacokinetic evaluation of a potential MRI contrast agent containing two paramagnetic centers with albumin binding affinity (2005)

Parac-Vogt, Tatjana N.; U0037070 JFA;, Kimpe, Kristof, Laurent, Sophie, Vander Elst, Luce, Burtea, Carmen, Chen, Feng; U0039628 ;, ...

A dinuclear gadolinium(III) complex of an amphiphilic chelating ligand, containing two diethylenetriamine-N,N,N',N'',N''-pentaacetate (DTPA) moieties bridged by a bisindole derivative with three...

Vegetation-Environment Relationships Among Woody Species in Four Canopy-Layers in an Old-Growth Mixed Mesophytic Forest (2005)

Ryan W. McEwan, Robert N. Muller, Brian C. McCarthy

We examined vegetation-environment relationships among woody species in four canopy-strata within an old-growth mixed mesophytic forest. We hypothesized that 1) the most important environmental...

The highest water exchange rate ever measured for a Gd(III) chelate (2005)

Mato-Iglesias, Marta, Platas-Iglesias, Carlos, Djanashvili, Kristina, Peters, Joop A., Toth, Eva, Balogh, Edina, ...

Relaxometric study of copper [15]metallacrown-5 gadolinium complexes derived from alpha-aminohydroxamic acids (2005)

Parac-Vogt, Tatjana N.; U0037070 JFA;, Pacco, Antoine; U0040175 ;, Nockemann, Peter; U0040976 ;, Laurent, Sophie, Muller, Robert N., Wickleder, Mathias, ...

Proton nuclear magnetic relaxation dispersion (NMRD) profiles were recorded between 0.24 mT and 1.4 T for lanthanum(III)- and gadolinium(III)-containing [15]metallacrown-5 complexes derived from...

MRI detection of early endothelial activation in brain inflammation (2004)

Sibson, Nicola R., Blamire, Andrew M., Bernades-Silva, Martine, Laurent, Sophie, Boutry, Sébastien, Muller, Robert N., ...

MRI is an increasingly important clinical tool, but it is clear that conventional imaging fails to identify the full extent of lesion load in certain conditions, such as multiple sclerosis. The aim...

Investigation of non-covalent interactions between paramagnetic complexes and human serum albumin by electrospray mass spectrometry (2004)

Henrotte, Virginie, Laurent, Sophie, Gabelica, Valérie, Vander Elst, Luce, De Pauw, Edwin, Muller, Robert N

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their...

Gadolinium DTPA-monoamide complexes incorporated into mixed micelles as possible MRI contrast agents (2004)

Parac-Vogt, Tatjana N.; U0037070 JFA;, Kimpe, Kristof, Laurent, Sophie, Pierart, Corinne, Vander Elst, Luce, Muller, Robert N., ...

Four monoamide derivatives of Gd-DTPA with alkyl chains consisting of 12, 14, 16, or 18 carbon atoms were synthesized. The gadolinium(III) complexes with chain lengths of 14, 16 or 18 carbon atoms...

Stability, structure and dynamics of cationic lanthanide(III) complexes of N,N'-bis(propylamide)ethylenediamine-N,N'-diacetic acid (2003)

Platas-Iglesias, Carlos, Corsi, Daniele M., Vander Elst, Luce, Muller, Robert N., Imbert, Daniel, Buenzli, Jean-Claude G., ...

Potential MRI contrast agents based on micellar incorporation of amphiphilic bis(alkylamide) derivatives of [(Gd-DTPA)(H2O)](2-) (2003)

Kimpe, Kristof; U0032982 JFA;, Parac-Vogt, Tatjana N.; U0037070 ;, Laurent, Sophie, Pierart, Corinne, Vander Elst, Luce, Muller, Robert N., ...

DTPA-bisamide derivatives with alkyl chains containing 14, 16 and 18 carbon atoms were synthesized and complexes of various trivalent lanthanide ions (Ln = Gd, La, Pr, Eu) were formed. Variable...

Synthesis, variable temperature and pressure 17O NMR study of bis(alkylamide) derivatives of [(Gd-DTPA)(H2O)]2- - An assessment of the substitution effect on water exchange kinetics (2002)

Botteman, Francois, Nicolle, Gaelle M., Vander Elst, Luce, Laurent, Sophie, Merbach, Andre E., Muller, Robert N.

Are Universities Leaders in the Stewardship of Conservation Lands? (2000)

ROBERT N. MULLER, DAVID S. MAEHR

A tripod gadolinium(III) poly(amino carboxylate) relevant to magnetic resonance imaging: structural and dynamical 17O NMR and 1H NMRD studies (1998)

Ruloff, Robert, Muller, Robert N., Pubanz, Dirk, Merbach, Andre E.

Structures and Dynamics of Lanthanide(III) Complexes of Sugar-Based DTPA-bis(amides) in Aqueous Solution: A Multinuclear NMR Study (1997)

Lammers, Hendrik, Maton, Frederic, Pubanz, Dirk, Van Laren, Martijn W., Van Bekkum, Herman, Merbach, Andre E., ...

Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke

Jin, Albert Y, Tuor, Ursula I, Rushforth, David, Kaur, Jaspreet, Muller, Robert N, Petterson, Jodie Lee, ...