Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster (2008)
Mackay, Trudy F. C, Anholt, Robert R. H
Understanding how the genome empowers the nervous system to express behaviors remains a critical challenge in behavioral genetics. The startle response is an attractive behavioral model for studies...
Yamamoto, Akihiko, Zwarts, Liesbeth, Callaerts-Végh, Zsuzsanna, ...
Behaviors are complex traits influenced by multiple pleiotropic genes. Understanding the mechanisms that give rise to complex behaviors requires an understanding of how variation in transcriptional...
Functional Genomics of Odor-guided Behavior in Drosophila melanogaster (2001)
Anholt, Robert R.H., Fanara, Juan José, Fedorowicz, Grazyna M., Ganguly, Indrani, Kulkarni, Nalini H., Mackay, Trudy F.C., ...
The avoidance response to repellent odorants in Drosophila melanogaster, a response essential for survival, provides an advantageous model for studies on the genetic architecture of olfactory...
Kulkarni, Nalini H, Yamamoto, Akihiko H, Robinson, Kellie O, Mackay, Trudy F C, Anholt, Robert R H
Previously, we generated P-element insert lines in Drosophila melanogaster with impaired olfactory behavior. One of these smell-impaired (smi) mutants, smi60E, contains a P[lArB] transposon in the...
Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.
Fanara, Juan José, Robinson, Kellie O, Rollmann, Stephanie M, Anholt, Robert R H, Mackay, Trudy F C
Most animals depend on olfaction for survival and procreation. Odor-guided behavior is a quantitative trait, with phenotypic variation due to multiple segregating quantitative trait loci (QTL)....
Borrás, Teresa, Morozova, Tatiana V, Heinsohn, Stefanie L, Lyman, Richard F, Mackay, Trudy F C, Anholt, Robert R H
The availability of the human genome sequence together with sequenced genomes of several model organisms provides an unprecedented opportunity to utilize comparative genomic approaches for the...
Scribble is essential for olfactory behavior in Drosophila melanogaster.
Ganguly, Indrani, Mackay, Trudy F C, Anholt, Robert R H
The ability to discriminate and respond to chemical signals from the environment is an almost universal prerequisite for survival. Here, we report that the scaffold protein Scribble is essential for...
Kulkarni, Nalini H, Yamamoto, Akihiko H, Robinson, Kellie O, Mackay, Trudy F C, Anholt, Robert R H
Previously, we generated P-element insert lines in Drosophila melanogaster with impaired olfactory behavior. One of these smell-impaired (smi) mutants, smi60E, contains a P[lArB] transposon in the...
Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.
Fanara, Juan José, Robinson, Kellie O, Rollmann, Stephanie M, Anholt, Robert R H, Mackay, Trudy F C
Most animals depend on olfaction for survival and procreation. Odor-guided behavior is a quantitative trait, with phenotypic variation due to multiple segregating quantitative trait loci (QTL)....
Borrás, Teresa, Morozova, Tatiana V, Heinsohn, Stefanie L, Lyman, Richard F, Mackay, Trudy F C, Anholt, Robert R H
The availability of the human genome sequence together with sequenced genomes of several model organisms provides an unprecedented opportunity to utilize comparative genomic approaches for the...
Scribble is essential for olfactory behavior in Drosophila melanogaster.
Ganguly, Indrani, Mackay, Trudy F C, Anholt, Robert R H
The ability to discriminate and respond to chemical signals from the environment is an almost universal prerequisite for survival. Here, we report that the scaffold protein Scribble is essential for...
Dynamic Genetic Interactions Determine Odor-Guided Behavior in Drosophila melanogaster
Sambandan, Deepa, Yamamoto, Akihiko, Fanara, Juan-José, Mackay, Trudy F. C., Anholt, Robert R. H.
Understanding the genetic architecture of complex traits requires identification of the underlying genes and characterization of gene-by-gene and genotype-by-environment interactions. Behaviors that...
The Early Developmental Gene Semaphorin 5c Contributes to Olfactory Behavior in Adult Drosophila
Rollmann, Stephanie M., Yamamoto, Akihiko, Goossens, Tim, Zwarts, Liesbeth, Callaerts-Végh, Zsuzsanna, Callaerts, Patrick, ...
Behaviors are complex traits influenced by multiple pleiotropic genes. Understanding the mechanisms that give rise to complex behaviors requires an understanding of how variation in transcriptional...
Wang, Ping, Lyman, Richard F., Shabalina, Svetlana A., Mackay, Trudy F. C., Anholt, Robert R. H.
Adaptive evolution of animals depends on behaviors that are essential for their survival and reproduction. The olfactory system of Drosophila melanogaster has emerged as one of the best characterized...
Sambandan, Deepa, Carbone, Mary Anna, Anholt, Robert R. H., Mackay, Trudy F. C.
Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to...
Pleiotropic Effects of Drosophila neuralized on Complex Behaviors and Brain Structure
Rollmann, Stephanie M., Zwarts, Liesbeth, Edwards, Alexis C., Yamamoto, Akihiko, Callaerts, Patrick, Norga, Koenraad, ...
Understanding how genotypic variation influences variation in brain structures and behavioral phenotypes represents a central challenge in behavioral genetics. In Drosophila melanogaster, the...
Carbone, Mary Anna, Ayroles, Julien F., Yamamoto, Akihiko, Morozova, Tatiana V., West, Steven A., Magwire, Michael M., ...
Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster
Yamamoto, Akihiko, Zwarts, Liesbeth, Callaerts, Patrick, Norga, Koenraad, Mackay, Trudy F. C., Anholt, Robert R. H.
Understanding how the genome empowers the nervous system to express behaviors remains a critical challenge in behavioral genetics. The startle response is an attractive behavioral model for studies...
Plasticity of the Chemoreceptor Repertoire in Drosophila melanogaster
Zhou, Shanshan, Stone, Eric A., Mackay, Trudy F. C., Anholt, Robert R. H.
For most organisms, chemosensation is critical for survival and is mediated by large families of chemoreceptor proteins, whose expression must be tuned appropriately to changes in the chemical...