Robert T. Kennedy

Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear (2006)

Venton, Barbara J., Robinson, Terry E., Kennedy, Robert T., Maren, Stephen

Glutamate and gamma-aminobutyric acid (GABA) release in the amygdala are thought to be crucial for the acquisition and expression of fear memories, but the time course of amino acid changes during...

Estradiol attenuates the K + -induced increase in extracellular GABA in rat striatum (2006)

Hu, Ming, Watson, Christopher J., Kennedy, Robert T., Becker, Jill B.

Estradiol acts rapidly and directly to inhibit L-type Ca 2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain Γ-aminobutyric acid (GABA), we hypothesized that...

Microscale sample deposition onto hydrophobic target plates for trace level detection of neuropeptides in brain tissue by MALDI-MS (2005)

Wei, Hui, Dean, Stacey L., Parkin, Mark C., Nolkrantz, Kerstin, O'Callaghan, James P., Kennedy, Robert T.

A sample preparation method that combines a modified target plate with a nanoscale reversed-phase column (nanocolumn) was developed for detection of neuropeptides by matrix-assisted laser...

Capillary liquid chromatography with MS 3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely–moving rats (2005)

Baseski, Holly M., Watson, Christopher J., Cellar, Nicholas A., Shackman, Jonathan G., Kennedy, Robert T.

In vivo microdialysis sampling was coupled to capillary liquid chromatography (LC)/electrospray ionization quadrupole ion trap mass spectrometry (MS) to monitor [Met]enkephalin and [Leu]enkephalin in...

Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits (2004)

Wei, Hui, Nolkrantz, Kerstin, Powell, David H., Woods, James H., Ko, Mei-Chuan, Kennedy, Robert T.

Electrospray sample deposition was explored for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). In this method, nanoliter volumes of matrix/analyte mixture...

GABAB Receptors Mediate Motility Signals for Migrating Embryonic Cortical Cells (2001)

Behar, Toby N., Smith, Susan V., Kennedy, Robert T., Mckenzie, Jacinth M., Maric, Irina, Barker, Jeffery L.

During development, postmitotic neurons migrate from germinal regions into the cortical plate (cp), where lamination occurs. In rats, GABA is transiently expressed in the cp, near target destinations...

Role of Glutamate Release and Metabotropic Autoreceptors in Seizureogenic Actions of Cholinomimetic Agents (1998)

Vickroy, Thomas W., Kennedy, Robert T.

The purpose of this project is to delineate the potential role(s) of excitatory amino acids (EAA) as mediators of central nervous system (CNS) excitation and seizures produced by centrally-active...

United States grades for perishable agricultural commodities /--by Robert T. Kennedy. (1956)

Kennedy, Robert T.

Thesis (M.A.)--Michigan State University of Agriculture and Applied Science. Dept. of General Business, Curriculum in Food Distribution, 1956.

Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells

Zhang, Qimin, Tally, Michael, Larsson, Olof, Kennedy, Robert T., Huang, Lan, Hall, Kerstin, ...

The insulin-like growth factor II (IGF-II)/mannose-6-phosphate (M-6-P) receptor is known to participate in endocytosis as well as sorting of lysosomal enzymes and is involved in membrane trafficking...

Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells

Zhang, Qimin, Tally, Michael, Larsson, Olof, Kennedy, Robert T., Huang, Lan, Hall, Kerstin, ...

The insulin-like growth factor II (IGF-II)/mannose-6-phosphate (M-6-P) receptor is known to participate in endocytosis as well as sorting of lysosomal enzymes and is involved in membrane trafficking...

A CE assay for the detection of agonist-stimulated adenylyl cyclase activity

Cunliffe, Jennifer M., Whorton, Matthew R., Sunahara, Roger K., Kennedy, Robert T.

A CE assay was developed for the detection of adenylyl cyclase (AC) activity stimulated at the AC and G protein-coupled receptor (GPCR) level. In the assay, cell membranes overexpressing GPCR and/or...

Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice

Morioka, Tomoaki, Asilmaz, Esra, Hu, Jiang, Dishinger, John F., Kurpad, Amarnath J., Elias, Carol F., ...

Obesity is characterized by hyperinsulinemia, hyperleptinemia, and an increase in islet volume. While the mechanisms that hasten the onset of diabetes in obese individuals are not known, it is...

Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy

Zhang, Hongyu, Saha, Jharna, Byun, Jaeman, Schin, MaryLee, Lorenz, Matthew, Kennedy, Robert T., ...

Recent studies suggest that thiazolidinediones ameliorate diabetic nephropathy (DN) independently of their effect on hyperglycemia. In the current study, we confirm and extend these findings by...