Host Cell Responses Induced by Hepatitis C Virus Binding (2009)
Xinhua Fang, Mirjam B. Zeisel, Jochen Wilpert, Bettina Gissler, Robert Thimme, Clemens Kreutz, ...
Initiation of hepatitis C virus (HCV) infection is mediated by docking of the viral envelope to the hepatocyte cell surface membrane followed by entry of the virus into the host cell. Aiming to...
Role of Host Genetic Factors in the Outcome of Hepatitis C Virus Infection (2009)
Bertram Bengsch, Robert Thimme, Hubert E. Blum
The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate...
A lymphotoxin-driven pathway to hepatocellular carcinoma. (2009)
Haybaeck, Johannes, Zeller, Nicolas, Wolf, Monika Julia, Weber, Achim, Wagner, Ulrich, Kurrer, Michael Odo, ...
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and their...
A lymphotoxin-driven pathway to hepatocellular carcinoma. (2009)
Haybaeck, Johannes, Zeller, Nicolas, Wolf, Monika Julia, Weber, Achim, Wagner, Ulrich, Kurrer, Michael Odo, ...
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and their...
A lymphotoxin-driven pathway to hepatocellular carcinoma. (2009)
Haybaeck, Johannes, Zeller, Nicolas, Wolf, Monika Julia, Weber, Achim, Wagner, Ulrich, Kurrer, Michael Odo, ...
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and their...
Host cell responses induced by hepatitis C virus binding. (2006)
Fang, Xinhua, Zeisel, Mirjam B, Wilpert, Jochen, Gissler, Bettina, Thimme, Robert, Kreutz, Clemens, ...
Initiation of hepatitis C virus (HCV) infection is mediated by docking of the viral envelope to the hepatocyte cell surface membrane followed by entry of the virus into the host cell. Aiming to...
Host cell responses induced by hepatitis C virus binding. (2006)
Fang, Xinhua, Zeisel, Mirjam B, Wilpert, Jochen, Gissler, Bettina, Thimme, Robert, Kreutz, Clemens, ...
Initiation of hepatitis C virus (HCV) infection is mediated by docking of the viral envelope to the hepatocyte cell surface membrane followed by entry of the virus into the host cell. Aiming to...
Host cell responses induced by hepatitis C virus binding. (2006)
Fang, Xinhua, Zeisel, Mirjam B, Wilpert, Jochen, Gissler, Bettina, Thimme, Robert, Kreutz, Clemens, ...
Initiation of hepatitis C virus (HCV) infection is mediated by docking of the viral envelope to the hepatocyte cell surface membrane followed by entry of the virus into the host cell. Aiming to...
Schutzwirkung des interferoninduzierten Mx1-Proteins der Maus gegenüber Dhorivirus / (1994)
[Mikrofiche-Ausg.].
Forns, Xavier, Thimme, Robert, Govindarajan, Sugantha, Emerson, Suzanne U., Purcell, Robert H., Chisari, Francis V., ...
Persistent infection with hepatitis C virus (HCV) is among the leading causes of chronic liver disease. Previous studies suggested that genetic variation in hypervariable region 1 (HVR1) of the...
Thimme, Robert, Chang, Kyong-Mi, Pemberton, Janell, Sette, Alessandro, Chisari, Francis V.
The recent identification of hepatitis B virus (HBV) epitopes restricted by multiple HLA alleles has greatly expanded the epitope repertoire available for T-cell-mediated therapeutic vaccine...
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Thimme, Robert, Bukh, Jens, Spangenberg, Hans Christian, Wieland, Stefan, Pemberton, Janell, Steiger, Carola, ...
To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and...
Genomic analysis of the host response to hepatitis C virus infection
Su, Andrew I., Pezacki, John P., Wodicka, Lisa, Brideau, Amy D., Supekova, Lubica, Thimme, Robert, ...
We have examined the progression of hepatitis C virus (HCV) infections by gene expression analysis of liver biopsies in acutely infected chimpanzees that developed persistent infection, transient...
Thimme, Robert, Wieland, Stefan, Steiger, Carola, Ghrayeb, John, Reimann, Keith A., Purcell, Robert H., ...
Although the CD4+- and CD8+-T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector...
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees
Wieland, Stefan F., Spangenberg, Hans Christian, Thimme, Robert, Purcell, Robert H., Chisari, Francis V.
We have previously shown that hepatitis B virus (HBV) replication is controlled by noncytolytic mechanisms that depend primarily on the effector functions of the CD8+ T cell response, especially the...
Genomic analysis of the host response to hepatitis B virus infection
Wieland, Stefan, Thimme, Robert, Purcell, Robert H., Chisari, Francis V.
Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune...
Boettler, Tobias, Spangenberg, Hans Christian, Neumann-Haefelin, Christoph, Panther, Elisabeth, Urbani, Simonetta, Ferrari, Carlo, ...
Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine, and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute significantly to...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
Boettler, Tobias, Panther, Elisabeth, Bengsch, Bertram, Nazarova, Natalja, Spangenberg, Hans Christian, Blum, Hubert E., ...
Virus-specific CD8+ T cells play a central role in the outcome of several viral infections, including hepatitis B virus (HBV) infection. A key feature of virus-specific CD8+ T cells is the...
Forns, Xavier, Thimme, Robert, Govindarajan, Sugantha, Emerson, Suzanne U., Purcell, Robert H., Chisari, Francis V., ...
Persistent infection with hepatitis C virus (HCV) is among the leading causes of chronic liver disease. Previous studies suggested that genetic variation in hypervariable region 1 (HVR1) of the...
Thimme, Robert, Chang, Kyong-Mi, Pemberton, Janell, Sette, Alessandro, Chisari, Francis V.
The recent identification of hepatitis B virus (HBV) epitopes restricted by multiple HLA alleles has greatly expanded the epitope repertoire available for T-cell-mediated therapeutic vaccine...
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
Thimme, Robert, Bukh, Jens, Spangenberg, Hans Christian, Wieland, Stefan, Pemberton, Janell, Steiger, Carola, ...
To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and...
Genomic analysis of the host response to hepatitis C virus infection
Su, Andrew I., Pezacki, John P., Wodicka, Lisa, Brideau, Amy D., Supekova, Lubica, Thimme, Robert, ...
We have examined the progression of hepatitis C virus (HCV) infections by gene expression analysis of liver biopsies in acutely infected chimpanzees that developed persistent infection, transient...
Thimme, Robert, Wieland, Stefan, Steiger, Carola, Ghrayeb, John, Reimann, Keith A., Purcell, Robert H., ...
Although the CD4+- and CD8+-T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector...
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees
Wieland, Stefan F., Spangenberg, Hans Christian, Thimme, Robert, Purcell, Robert H., Chisari, Francis V.
We have previously shown that hepatitis B virus (HBV) replication is controlled by noncytolytic mechanisms that depend primarily on the effector functions of the CD8+ T cell response, especially the...
Genomic analysis of the host response to hepatitis B virus infection
Wieland, Stefan, Thimme, Robert, Purcell, Robert H., Chisari, Francis V.
Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune...
Boettler, Tobias, Spangenberg, Hans Christian, Neumann-Haefelin, Christoph, Panther, Elisabeth, Urbani, Simonetta, Ferrari, Carlo, ...
Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine, and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute significantly to...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
Boettler, Tobias, Panther, Elisabeth, Bengsch, Bertram, Nazarova, Natalja, Spangenberg, Hans Christian, Blum, Hubert E., ...
Virus-specific CD8+ T cells play a central role in the outcome of several viral infections, including hepatitis B virus (HBV) infection. A key feature of virus-specific CD8+ T cells is the...
Bengsch, Bertram, Spangenberg, Hans Christian, Kersting, Nadine, Neumann-Haefelin, Christoph, Panther, Elisabeth, Von Weizsäcker, Fritz, ...
The differentiation and functional status of virus-specific CD8+ T cells is significantly influenced by specific and ongoing antigen recognition. Importantly, the expression profiles of the...
Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection
Lucas, Michaela, Ulsenheimer, Axel, Pfafferot, Katja, Heeg, Malte H.J., Gaudieri, Silvana, Grüner, Norbert, ...
Sakai, Akito, Takikawa, Shingo, Thimme, Robert, Meunier, Jean-Christophe, Spangenberg, Hans Christian, Govindarajan, Sugantha, ...
Both viral and host factors are thought to influence the pathogenesis of hepatitis C virus (HCV) infection. We studied strain HC-TN (genotype 1a), which caused fulminant hepatic failure in a patient...
Holzinger, Dirk, Jorns, Carl, Stertz, Silke, Boisson-Dupuis, Stéphanie, Thimme, Robert, Weidmann, Manfred, ...
The human MxA gene belongs to the class of interferon (IFN)-stimulated genes (ISGs) involved in antiviral resistance against influenza viruses. Here, we studied the requirements for MxA induction by...
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
Thimme, Robert, Oldach, David, Chang, Kyong-Mi, Steiger, Carola, Ray, Stuart C., Chisari, Francis V.
The virological and immunological features of hepatitis C virus (HCV) infection were studied weekly for 6 months after accidental needlestick exposure in five health care workers, four of whom...
Neumann-Haefelin, Christoph, Frick, David N., Wang, Jing Jing, Pybus, Oliver G., Salloum, Shadi, Narula, Gagandeep S., ...
Failure of the adaptive immune response to control infection with the hepatitis C virus (HCV) can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune...
Barth, Heidi, Schnober, Eva K., Neumann-Haefelin, Christoph, Thumann, Christine, Zeisel, Mirjam B., Diepolder, Helmut M., ...
Class B scavenger receptors (SR-Bs) bind lipoproteins and play an important role in lipid metabolism. Most recently, SR-B type I (SR-BI) and its splicing variant SR-BII have been found to mediate...
Bukh, Jens, Thimme, Robert, Meunier, Jean-Christophe, Faulk, Kristina, Spangenberg, Hans Christian, Chang, Kyong-Mi, ...
Protective immunity after resolved hepatitis C virus (HCV) infection has been reported. However, the breadth of this immunity has remained controversial, and the role of neutralizing antibodies has...
Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs ▿
Salloum, Shadi, Oniangue-Ndza, Cesar, Neumann-Haefelin, Christoph, Hudson, Laura, Giugliano, Silvia, Aus Dem Siepen, Marc, ...
The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes...
Evolving therapies in the treatment of hepatocellular carcinoma
Spangenberg, Hans Christian, Thimme, Robert, Blum, Hubert E
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The major etiologies and risk factors for HCC development are well defined and some of the steps involved in...