To Be or Not to Be: Predicting Soluble SecAs as Membrane Proteins (2008)
Hae-jin Hu, Student Member, Jeanetta Holley, Jieyue He, Robert W. Harrison, Hsiuchin Yang, ...
Abstract—SecA is an important component of protein translocation in bacteria, and exists in soluble and membrane-integrated forms. Most membrane prediction programs predict SecA as being a soluble...
Gulsah Altun, Hae-jin Hu, Dumitru Brinza, Robert W. Harrison, Alex Zelikovsky, Yi Pan
Abstract—The Support Vector Machine is a powerful methodology for solving problems in nonlinear classification, function estimation and density estimation. When data are not linearly separable,...
BACKGROUND Linear Programming for Protein-Protein Interaction Prediction (2008)
Gulsah Altun, Stefan Gremalschi, Robert W. Harrison, Er Zelikovsky
has been assumed that protein families that interact with each other must
Xuezheng Fu, Under Direction, Robert W. Harrison, Xuezheng Fu, Xuezheng Fu, Xuezheng Fu, ...
Biological data is accumulated at a fast pace. However, raw data are generally difficult to understand and not useful unless we unlock the information hidden in the data. Knowledge/information can be...
Domain specific languages for cellular interactions (2004)
William L. Harrison, Robert W. Harrison
Bioinformatics is the application of Computer Science techniques to problems in Biology, and this paper explores one such application with great potential: the modeling of life cycles of autonomous,...
Close pairs of carboxylates: a possibility of multicenter hydrogen bonds in proteins (2003)
Torshin, Ivan Y., Harrison, Robert W., Weber, Irene T.
Covalent attachment of hydrogen to the donor atom may be not an essential characteristic of stable hydrogen bonds. A positively charged particle (such as a proton), located between the two negatively...
Torshin, Ivan Y., Weber, Irene T., Harrison, Robert W.
Empirical criteria for identification of hydrogen bonds were analyzed to produce a set of geometrically consistent criteria. For a data set of 30 structures, application of a set of purely...
Serio, Dawn, Singh, Satya P., Cartas, Maria A., Weber, Irene T., Harrison, Robert W., Louis, John M., ...
The processing of precursor proteins (Gag and Gag-pol) by the viral protease is absolutely required in order to generate infectious particles. This prompted us to consider novel strategies that...
Molecular mechanics analysis of drug-resistant mutants of HIV protease (1999)
Weber, Irene T., Harrison, Robert W.
Drug-resistant mutants of HIV-1 protease limit the long-term effectiveness of current anti-viral therapy. In order to study drug resistance, the wild-type HIV-1 protease and the mutants R8Q, V32I,...
Weber, Irene T., Harrison, Robert W.
Molecular models of HIV-1 protease and 21 peptide substrates with single amino acid substitutions at positions from P4 to P3′ were built and compared with kinetic measurements. The crystal...
Scott, Sean-Patrick, Harrison, Robert W., Weber, Irene T., Tanaka, Jacqueline C.
Cyclic nucleotide-gated channels (CNGC) open in response to the binding of 3′,5′-cyclic nucleotides. Members of the CNGC family vary as much as 100-fold in their ability to respond to cAMP and...
Includes vita and abstract.
Includes vita and abstract.
The Fourier-Green's function and the rapid evaluation of molecular potentials (1994)
Harrison, Robert W., Kourinov, Igor V., Andrews, Lawrence C.
Two tasks must be accomplished when calculating the binding modalities and binding energies of two molecules in solution: the calculation of the interaction energy and the calculation of the effects...
Molecular dynamics simulations of HIV-1 protease with peptide substrate (1994)
Harrison, Robert W., Weber, Irene T.
Molecular dynamics simulations of human immunodeficiency virus (HIV)-l protease with a model substrate were used to test if there is a stable energy minimum for a proton that is equidistant from the...
Thesis (M.S.)--Clemson University, 1988.
Roots of clay [microform] : search for contemporary context / (1981)
Thesis (M.F.A.)--University of Denver, 1981.
A beam transport system for the medical facility at Triumf /--by Robert W. Harrison. (1972)
Cover title.
ix, 254 p.
Classification of agricultural areas in Maryland, with special reference to Frederick County. (1940)
Typescript.
Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies
Fu, Zheng-Qing, Du Bois, Garrett C., Song, Sherry P., Kulikovskaya, Irina, Virgilio, Laura, Rothstein, Jay L., ...
Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to...
Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, ...
We designed, synthesized, and identified UIC-94017 (TMC114), a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing a...
β3-adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractility
Varghese, Paul, Harrison, Robert W., Lofthouse, Robert A., Georgakopoulos, Dimitrios, Berkowitz, Dan E., Hare, Joshua M.
The cardiac β-adrenergic pathway potently stimulates myocardial performance, thereby providing a mechanism for myocardial contractile reserve. β-Adrenergic activation also increases cardiac nitric...
Tie, Yunfeng, Boross, Peter I., Wang, Yuan-Fang, Gaddis, Laquasha, Liu, Fengling, Chen, Xianfeng, ...
HIV-1 protease (PR) and two drug-resistant variants – PR with the V82A mutation (PRV82A) and PR with the I84V mutation (PRI84V) – were studied using reduced peptide analogs of five natural...
Liu, Fengling, Boross, Peter I., Wang, Yuan-Fang, Tozser, Jozsef, Louis, John M., Harrison, Robert W., ...
The crystal structures, dimer stabilities, and kinetics have been analyzed for wild-type human immunodeficiency virus type 1 (HIV-1) protease (PR) and resistant mutants PRL24I, PRI50V, and PRG73S to...
Guo, Xiangxue, Harrison, Robert W., Tai, Phang C.
The cytoplasmic membrane proteins CvaB and CvaA and the outer membrane protein TolC constitute the bacteriocin colicin V secretion system in Escherichia coli. CvaB functions as an ATP-binding...
Advances in Diabetes for the Millennium: Diabetes in Minorities
Jovanovic, Lois, Harrison, Robert W
Diabetes shows an increased prevalence among minority groups, including Asians, African Americans, Hispanics, Native Americans, and Pacific Islanders. The sedentary lifestyle and high-fat diet of...
Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies
Fu, Zheng-Qing, Du Bois, Garrett C., Song, Sherry P., Kulikovskaya, Irina, Virgilio, Laura, Rothstein, Jay L., ...
Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to...
Koh, Yasuhiro, Nakata, Hirotomo, Maeda, Kenji, Ogata, Hiromi, Bilcer, Geoffrey, Devasamudram, Thippeswamy, ...
We designed, synthesized, and identified UIC-94017 (TMC114), a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing a...
β3-adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractility
Varghese, Paul, Harrison, Robert W., Lofthouse, Robert A., Georgakopoulos, Dimitrios, Berkowitz, Dan E., Hare, Joshua M.
The cardiac β-adrenergic pathway potently stimulates myocardial performance, thereby providing a mechanism for myocardial contractile reserve. β-Adrenergic activation also increases cardiac nitric...
Guo, Xiangxue, Harrison, Robert W., Tai, Phang C.
The cytoplasmic membrane proteins CvaB and CvaA and the outer membrane protein TolC constitute the bacteriocin colicin V secretion system in Escherichia coli. CvaB functions as an ATP-binding...
Advances in Diabetes for the Millennium: Diabetes in Minorities
Jovanovic, Lois, Harrison, Robert W
Diabetes shows an increased prevalence among minority groups, including Asians, African Americans, Hispanics, Native Americans, and Pacific Islanders. The sedentary lifestyle and high-fat diet of...
Shi, Yun, Chen, Xianfeng, Wu, Zhongying, Shi, Weiwei, Yang, Yang, Cui, Ningren, ...
Vascular ATP-sensitive K+ channels are activated by multiple vasodilating hormones and neurotransmitters via PKA. A critical PKA phosphorylation site (Ser-1387) is found in the second...