Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush (2009)
Templeton, Justin P, Nassr, Mohamed, Vazquez-Chona, Felix, Freeman-Anderson, Natalie E, Orr, William E, Williams, Robert W, ...
Abstract Background Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed,...
Gaglani, Shiv M, Lu, Lu, Williams, Robert W, Rosen, Glenn D
Abstract Background The size of the cerebral cortex varies widely within human populations, and a large portion of this variance is modulated by genetic factors. The discovery and characterization of...
Koutnikova, Hana, Laakso, Markku, Lu, Lu, Combe, Roy, Paananen, Jussi, Kuulasmaa, Teemu, ...
Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human...
Druka, Arnis, Druka, Ilze, Centeno, Arthur G, Li, Hongqiang, Sun, Zhaohui, Thomas, William TB, ...
Abstract Background A typical genetical genomics experiment results in four separate data sets; genotype, gene expression, higher-order phenotypic data and metadata that describe the protocols,...
Lu, Lu, Wei, Lai, Peirce, Jeremy L, Wang, Xusheng, Zhou, Jianhua, Homayouni, Ramin, ...
Abstract Background Successful strategies for QTL gene identification benefit from combined experimental and bioinformatic approaches. Unique design aspects of the BXD recombinant inbred line mapping...
The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience (2008)
Gardner, Daniel, Akil, Huda, Ascoli, Giorgio A., Bowden, Douglas M., Bug, William, Donohue, Duncan E., ...
With support from the Institutes and Centers forming the NIH Blueprint for Neuroscience Research, we have designed and implemented a new initiative for integrating access to and use of Web-based...
in Recombinant Inbred Strains A Relational Model System to Explore Neurobehavioral (2008)
Giorgio A. Ascoli, Erik De Schutter, David N. Kennedy, Gene Expression, Elissa J. Chesler, Jintao Wang, ...
Copyright ©Humana Press Inc.
The Collaborative Cross: Rationale, Implementation, and Costs (2008)
Robert W. Williams, Gary A. Churchill
“Most genetic traits of interest in populations of humans and other organisms are determined by many factors, including genetic and environmental components, which interact in often unpredictable...
NEW DEVELOPMENTS Seeing the Unseen: Microarray-Based Gene Expression Profiling in Vision (2008)
Sepideh Zareparsi, Alfred Hero, Donald J. Zack, Robert W. Williams, Anand Swaroop
Completion of genome sequencing efforts of humans and model organisms 1–3 have provided exciting opportunities for vision research. Questions that were hard to envisage, let alone resolve, suddenly...
Cell Production and Cell Death in the Generation of Variation in Neuron Number (2008)
Richelle C. Strom, Robert W. Williams
Retinal ganglion cell numbers in adult mice vary from 40,000 to 80,000. Much of this variation and the prominent bimodality of strain averages are generated by allelic variants at the neuron number...
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome (2008)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Robert W. Williams, Richard Mott, ...
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using...
Jan, Taha A, Lu, Lu, Li, Cheng-Xiang, Williams, Robert W, Waters, Robert S
Abstract Background Quantitative trait locus (QTL) mapping is an important tool for identifying potential candidate genes linked to complex traits. QTL mapping has been used to identify genes...
Reiner, David J., Jan, Taha A., Boughter, John D., Li, Cheng-Xiang, Lu, Lu, Williams, Robert W., ...
Quantitative trait loci (QTLs) analysis has been used to examine natural variation of phenotypes in the mouse somatosensory cortex, hippocampus, cerebellum, and amygdala. QTL analysis has also been...
Dale Hogan, Preston E. Garraghty, Robert W. Williams
this report we analyze a novel variant of the achiasmatic mutation, one in which retinal axons from only one eye successfully cross midline and in which the great majority of fibers from both eyes...
Ny Times, Nicholas Wade, Robert W. Williams, Karl W. Broman, Leonard C. Schalkwyk, David W. Threadgill
“There is also a Complex Traits Consortium, whose aim is to find the genetic roots of the many important diseases that are caused by several genes acting in concert. That goal has long eluded human...
Dennis S. Rice, Dan Goldowitz, Robert W. Williams, Kristin Hamre, Patrick T. Johnson, Seong-seng Tan, ...
Tyrosinase is a key enzyme involved in the synthesis of melanin in the retinal pigment epithelium (RPE). Mice that are homozygous for the albino allele at the tyrosinase locus have fewer retinal...
Guomin Zhou, Richelle C. Strom, Vincent Giguere, Robert W. Williams
Purpose: The retinoic acid receptors are expressed from early stages of development in the diverse tissues that make up the vertebrate eye. Their loss has subtle effects on eye development. We...
Robert W Williams, Jing Gu, Shuhua Qi, Lu Lu
(Print ISSN 1465-6906; Online ISSN 1465-6914) Background: Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. They have proved particularly...
Cover: by Janet Parke. Modified from Vikon fractal. www.infinite-art.com (2007)
Reproduced With Permission, Ny Times, Nicholas Wade, Robert W. Williams, Karl W. Broman, Leonard C. Schalkwyk, ...
The goal of the Complex Trait Consortium (CTC) is to produce greatly improved resources that can be used to understand, treat, and ultimately prevent the most pervasive human diseases. Essentially...
SHORT TITLE: Retinal Development (2007)
Developmental And Genetic, Robert W. Williams, Sally A. Moody, Leo W. Buss
Introduction The retina is one of the most highly conserved parts of the central nervous system, with unambiguous homology of major cell types among most chordates. These cells and their progenitors...
Workshop report: 1st INCF Workshop on Mouse and Rat Brain Digital Atlasing Systems (2007)
Jyl Boline, Michael Hawrylycz, Robert W. Williams
The goal of this workshop was to survey current activities and plans related to development of mouse and rat brain digital atlasing systems. The workshop discussed needs for and types of coordinated...
Mapping the genetic architecture of complex traits in experimental populations (2007)
Yang, Jian, Zhu, Jun, Williams, Robert W.
Summary: Understanding how interactions among set of genes affect diverse phenotypes is having a greater impact on biomedical research, agriculture and evolutionary biology. Mapping and...
Bao, Lei, Peirce, Jeremy L., Zhou, Mi, Li, Hongqiang, Goldowitz, Dan, Williams, Robert W., ...
Naturally occurring genetic variations may affect certain phenotypes through influencing transcript levels of the genes that are causally related to those phenotypes. Genomic regions harboring common...
Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes: Authors' Reply (2007)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Richard Mott, Jonathan Flint, ...
Genomic Loci Modulating the Retinal Transcriptome in Wound Healing (2007)
Lu Lu, Robert W. Williams, Eldon E. Geisert
Purpose: The present study predicts and tests genetic networks that modulate gene expression during the retinal wound-healing response.Methods: Upstream modulators and target genes were defined using...
Jyl Boline, Michael Hawrylycz, Robert W. Williams, Andreas Hess
www.incf.org
PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits (2007)
Bao, Lei, Zhou, Mi, Wu, Ligang, Lu, Lu, Goldowitz, Dan, Williams, Robert W., ...
Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations in putative microRNA target sites. PolymiRTSs may affect gene expression and cause...
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome (2006)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Robert W. Williams, Richard Mott, ...
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using...
Combined Expression Trait Correlations and Expression Quantitative Trait Locus Mapping (2006)
Hong Lan, Meng Chen, Jessica B. Flowers, Brian S. Yandell, Donnie S. Stapleton, Christine M. Mata, ...
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. The consideration of gene...
PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits (2006)
Bao, Lei, Zhou, Mi, Wu, Ligang, Lu, Lu, Goldowitz, Dan, Williams, Robert W., ...
Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations in putative microRNA target sites. PolymiRTSs may affect gene expression and cause...
Li, Hongqiang, Chen, Hao, Bao, Lei, Manly, Kenneth F., Chesler, Elissa J., Lu, Lu, ...
Genetic loci that regulate inherited traits are routinely identified using quantitative trait locus (QTL) mapping methods. However, the genotype–phenotype associations do not provide information on...
PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits (2006)
Bao, Lei, Zhou, Mi, Wu, Ligang, Lu, Lu, Goldowitz, Dan, Williams, Robert W., ...
Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations in putative microRNA target sites. PolymiRTSs may affect gene expression and cause...
Combined Expression Trait Correlations and Expression Quantitative Trait Locus Mapping (2005)
Hong Lan, Meng Chen, Jessica B. Flowers, Brian S. Yandell, Donald S. Stapleton, Christine M. Mata, ...
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. The consideration of gene...
Bystrykh, Leonid, Weersing, Ellen, Dontje, Bert, Sutton, Sue, Pletcher, Mathew T., Wiltshire, Tim, ...
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs...
Nicole E. Baldwin, Elissa J. Chesler, Stefan Kirov, Michael A. Langston, Jay R. Snoddy, Robert W. Williams, ...
Abstract. Gene expression microarray data can be used for the assembly of genetic co-expression network graphs. Using mRNA samples obtained from recombinant inbred Mus musculus strains, it is...
Inferring gene transcriptional modulatory relations: a genetical genomics approach (2005)
Hongqiang Li, Kenneth F. Manly, Elissa J. Chesler, Lei Bao, Jintao Wang, Mi Zhou, ...
Nicole E. Baldwin, Elissa J. Chesler, Stefan Kirov, Michael A. Langston, Jay R. Snoddy, Robert W. Williams, ...
Gene expression microarray data is being increasingly used for the assembly of gene network graphs. Using mRNA samples obtained from recombinant inbred Mus musculus strains, it is possible to study...
Nicole E. Baldwin, Elissa J. Chesler, Stefan Kirov, Michael A. Langston, Jay R. Snoddy, Robert W. Williams, ...
Gene expression microarray data can be used for the assembly of genetic coexpression network graphs. Using mRNA samples obtained from recombinant inbred Mus musculus strains, it is possible to...
Inferring gene transcriptional modulatory relations: a genetical genomics approach (2005)
Li, Hongqiang, Lu, Lu, Manly, Kenneth F., Chesler, Elissa J., Bao, Lei, Wang, Jintao, ...
Bayesian network modeling is a promising approach to define and evaluate gene expression circuits in diverse tissues and cell types under different experimental conditions. The power and practicality...
Inferring Gene Transcriptional Modulatory Relations: A Genetical Genomics Approach (2005)
Li, Hongqiang, Lu, Lu, Manly, Kenneth F., Chesler, Elissa J., Bao, Lei, Wang, Jintao, ...
Bayesian network modeling is a promising approach to define and evaluate gene expression circuits in diverse tissues and cell types under different experimental conditions. The power and practicality...
Li, Hongqiang, Chen, Hao, Bao, Lei, Manly, Kenneth F., Chesler, Elissa J., Lu, Lu, ...
Genetic loci that regulate inherited traits are routinely identified using quantitative trait locus (QTL) mapping methods. However, the genotype-phenotype associations do not provide information on...
Floyd Keels, Treasurer Directors (2004)
Kenneth W. Jackson, Vice Chair, Melissa Johnson Emery, James A. Brown, Hal Campbell, William W. Coleman, ...
FMU Foundation
BMC Genetics BioMed Central Methodology article (2004)
Jeremy L Peirce, Lu Lu, Jing Gu, Lee M Silver, Robert W Williams
A new set of BXD recombinant inbred lines from advanced intercross populations in mice
GenomeMixer: a complex genetic cross simulator (2004)
Williams, Alexander G., Williams, Robert W.
Summary: GenomeMixer is a cross-platform application that simulates meiotic recombination events for large and complex multigenerational genetic crosses among sexually reproducing diploid species and...
Eric Clai, Pavel Tomancak, Robert W Williams, Gerald M Rubin
The electronic version of this article is the complete one and can be found online at
ISSN 1539--2791 Volume 1 . Number 4 . 2003 (2003)
Editors Giorgio Ascoli, Giorgio A. Ascoli, Erik De Schutter, David N. Kennedy, Gene Expression, Glenn D. Rosen, ...
In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS)...
Towards effective and rewarding data sharing [Editorial] (2003)
Gardner, Daniel, Toga, Arthur W., Ascoli, Giorgio A., Beatty, Jackson, Brinkley, James F., Dale, Anders M., ...
reality via a community effort (2002)
Genetic Dissection Of, David W. Threadgill, Kent W. Hunter, Robert W. Williams
ry genetic resources and phenotypic diversity archived in extant inbred strains (Paigen and Eppig 2000). As a result, over 50 strains are currently being screened as part of the Mouse Phenome Project...
Genetic Sources of Individual Differences in the Cerebellum (2002)
David Airey Lu, Lu Lu, Siming Shou, Robert W Williams
Introduction Understanding the causes of individual differences in cerebellar structure and function will require a battery of techniques. These will include modern and classical genetic methods such...
Lu Lu, David C. Airey, Robert W. Williams
Notable differences in hippocampal structure are associated with intriguing differences in development and behavioral capabilities. We explored genetic and environmental factors that modulate...
David C. Airey, Lu Lu, Robert W. Williams
To discover genes influencing cerebellum development, we conducted a complex trait analysis of variation in the size of the adult mouse cerebellum. We analyzed two sets of recombinant inbred BXD...
John K. Belknap, Robert Hitzemann, John C. Crabbe, Tamara J. Phillips, Kari J. Buck, Robert W. Williams, ...
Quantitative genetics and QTL mapping have undergone a revolution in the last decade. Progress in the next decade promises to be at least as rapid, and strategies for fine mapping QTLs and...
Glenn D. Rosen, Glenn D. Rosen, Robert W. Williams, Robert W. Williams
Rosen & Williams, Page 2 Background: The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in...
Williams, Robert W., Meyerowitz, Elliot M., Clark, Steven E.
With the advance of Arabidopsis as a model system for understanding plant genetics, development and biochemistry, a detailed description of the genome is necessary. As such, focused projects are...
Robert W. Williams, Richelle C. Strom, Dan Goldowitz
Common genetic polymorphisms—as opposed to rare mutations—generate almost all heritable differences in the size and structure of the CNS. Surprisingly, these normal variants have not previously...
Genetic and environmental control of variation in retinal ganglion cell number in mice (1996)
Robert W. Williams, Richelle C. Strom, Dennis S. Rice, Dan Goldowitz
How much of the remarkable variation in neuron number within a species is generated by genetic differences, and how much is generated by environmental factors? We address this problem for a single...
Bastiani, Michael, Williams, Robert W.; Chalupa, Leo M.
Between the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population...
Bastiani, Michael, Williams, Robert W.; Chalupa, Leo M.
Between the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population...
Abdeltawab, Nourtan F., Aziz, Ramy K., Kansal, Rita, Rowe, Sarah L., Su, Yin, Gardner, Lidia, ...
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain. We had provided evidence that HLA class...
The USU medical PDA initiative: the PDA as an educational tool.
Moore, Leon, Richardson, Bradley R., Williams, Robert W.
A medical personal digital assistant (PDA) initiative for healthcare students began in 2000 at the Uniformed Services University of the Health Sciences (USU). The University issued PDAs to Graduate...
Mozhui, Khyobeni, Ciobanu, Daniel C., Schikorski, Thomas, Wang, Xusheng, Lu, Lu, Williams, Robert W.
A remarkably diverse set of traits maps to a region on mouse distal chromosome 1 (Chr 1) that corresponds to human Chr 1q21–q23. This region is highly enriched in quantitative trait loci (QTLs)...
McLachlan, Sandra M., Aliesky, Holly A., Pichurin, Pavel N., Chen, Chun-Rong, Williams, Robert W., Rapoport, Basil
Susceptibility genes for TSH receptor (TSHR) antibodies and hyperthyroidism can be probed in recombinant inbred (RI) mice immunized with adenovirus expressing the TSHR A-subunit. The RI set of CXB...
Artificial trans-Acting siRNAs Confer Consistent and Effective Gene Silencing
Aukerman, Milo J., Sakai, Hajime, Tingey, Scott V., Williams, Robert W.
Manipulating gene expression is critical to exploring gene function and a useful tool for altering commercial traits. Techniques such as hairpin-based RNA interference, virus-induced gene silencing,...
Koutnikova, Hana, Laakso, Markku, Lu, Lu, Combe, Roy, Paananen, Jussi, Kuulasmaa, Teemu, ...
Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human...
Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
Templeton, Justin P, Nassr, Mohamed, Vazquez-Chona, Felix, Freeman-Anderson, Natalie E, Orr, William E, Williams, Robert W, ...
Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice
Geisert, Eldon E., Lu, Lu, Freeman-Anderson, Natalie E., Templeton, Justin P., Nassr, Mohamed, Wang, Xusheng, ...
Reiner, David J., Jan, Taha A., Boughter, John D., Li, Cheng-Xiang, Lu, Lu, Williams, Robert W., ...
Quantitative trait loci (QTLs) analysis has been used to examine natural variation of phenotypes in the mouse somatosensory cortex, hippocampus, cerebellum, and amygdala. QTL analysis has also been...