Robert Weissert

NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity (2008)

Greve, Bernhard, Hoffmann, Peter, Vonthein, Reinhard, Kun, Jürgen, Lell, Bertrand, Mycko, Marcin P, ...

Abstract Background Neutrophil cytosolic factor 1, p47 phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an...

Experimentelle neuroimmunogenetische Untersuchungen zur Autoaggression und Therapie der Multiplen Sklerose (2004)

Weissert, Robert

Die Arbeit ‚Experimentelle neuroimmunogenetische Untersuchungen zur Autoaggression und Therapie der Multiplen Sklerose’ untersucht im Ratten- und im humanisierten transgenen Mausmodell die...

Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis (2001)

Kornek, Barbara, Storch, Maria K., Bauer, Jan, Djamshidian, Atbin, Weissert, Robert, Wallstroem, Erik, ...

Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are immune-mediated diseases of the CNS. They are characterized by widespread inflammation, demyelination and a variable degree...

Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity (1999)

De Graaf, Katrien L., Weissert, Robert, Kjellén, Peter, Holmdahl, Rikard, Olsson, Tomas

The impact of the strength and promiscuity of the self peptide–MHC class II interaction on susceptibility to autoimmune disease is uncertain. Here we studied allelic differences in the affinity of...

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

Weissert, Robert, Lobell, Anna, De Graaf, Katrien L., Eltayeb, Sana Yousif, Andersson, Roland, Olsson, Tomas, ...

DNA vaccines that encode encephalitogenic sequences in tandem can protect from subsequent experimental autoimmune encephalomyelitis induced with the corresponding peptide. The mechanism for this...

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

Weissert, Robert, Lobell, Anna, De Graaf, Katrien L., Eltayeb, Sana Yousif, Andersson, Roland, Olsson, Tomas, ...

DNA vaccines that encode encephalitogenic sequences in tandem can protect from subsequent experimental autoimmune encephalomyelitis induced with the corresponding peptide. The mechanism for this...

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis : A Comparative Quantitative Study of Axonal Injury in Active, Inactive, and Remyelinated Lesions

Kornek, Barbara, Storch, Maria K., Weissert, Robert, Wallstroem, Erik, Stefferl, Andreas, Olsson, Tomas, ...

Recent magnetic resonance (MR) studies of multiple sclerosis lesions indicate that axonal injury is a major correlate of permanent clinical deficit. In the present study we systematically quantified...

CD8+ Phagocyte Recruitment in Rat Experimental Autoimmune Encephalomyelitis: Association with Inflammatory Tissue Destruction

Schroeter, Michael, Stoll, Guido, Weissert, Robert, Hartung, Hans-Peter, Lassmann, Hans, Jander, Sebastian

Increasing evidence suggests an important role of CD8+ cells in the pathogenesis of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). In our present study we...

Enhanced Glucocorticoid Receptor Signaling in T Cells Impacts Thymocyte Apoptosis and Adaptive Immune Responses

Brandt, Jens Van Den, Lühder, Fred, McPherson, Kirsty G., De Graaf, Katrien L., Tischner, Denise, Wiehr, Stefan, ...

To study the effect of enhanced glucocorticoid signaling on T cells, we generated transgenic rats overexpressing a mutant glucocorticoid receptor with increased ligand affinity in the thymus. We...

Identification of HLA-DR–bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis

Wahlström, Jan, Dengjel, Jörn, Persson, Bengt, Duyar, Hüseyin, Rammensee, Hans-Georg, Stevanoviδc, Stefan, ...

Sarcoidosis is an inflammatory disease of unknown etiology, most commonly affecting the lungs. Activated CD4+ T cells accumulate in the lungs of individuals with sarcoidosis and are considered to be...

Vaccination with DNA Encoding an Immunodominant Myelin Basic Protein Peptide Targeted to Fc of Immunoglobulin G Suppresses Experimental Autoimmune Encephalomyelitis

Lobell, Anna, Weissert, Robert, Storch, Maria K., Svanholm, Cecilia, De Graaf, Katrien L., Lassmann, Hans, ...

We explore here if vaccination with DNA encoding an autoantigenic peptide can suppress autoimmune disease. For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an...