Yin Yang 1 is a critical regulator of B-cell development (2007)
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
kappa chain monoallelic demethylation and the establishment of allelic exclusion (1998)
Mostoslavsky, Raul, Singh, Nandita, Kirillov, Andrei, Pelanda, Roberta, Cedar, Howard, Chess, Andrew, ...
Braun, Uschi, Rajewsky, Klaus, Pelanda, Roberta
Ig knock-in mice have been used to study the relative contribution of receptor selection versus clonal selection in the control of autoreactive B cells. The anti-MHC class I 3-83Ig knock-in (3-83Igi)...
κ chain monoallelic demethylation and the establishment of allelic exclusion
Mostoslavsky, Raul, Singh, Nandita, Kirillov, Andrei, Pelanda, Roberta, Cedar, Howard, Chess, Andrew, ...
Allelic exclusion in κ light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional κ light chain on the surface of the B cell leads to an...
Braun, Uschi, Rajewsky, Klaus, Pelanda, Roberta
Ig knock-in mice have been used to study the relative contribution of receptor selection versus clonal selection in the control of autoreactive B cells. The anti-MHC class I 3-83Ig knock-in (3-83Igi)...
κ chain monoallelic demethylation and the establishment of allelic exclusion
Mostoslavsky, Raul, Singh, Nandita, Kirillov, Andrei, Pelanda, Roberta, Cedar, Howard, Chess, Andrew, ...
Allelic exclusion in κ light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional κ light chain on the surface of the B cell leads to an...
Yin Yang 1 is a critical regulator of B-cell development
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
Galler, Gunther R., Mundt, Cornelia, Parker, Mathew, Pelanda, Roberta, Mårtensson, Inga-Lill, Winkler, Thomas H.
Early B cell development is characterized by stepwise, ordered rearrangement of the immunoglobulin (Ig) heavy (HC) and light (LC) chain genes. Only one of the two alleles of these genes is used to...
Novobrantseva, Tatiana I., Martin, Verena M., Pelanda, Roberta, Müller, Werner, Rajewsky, Klaus, Ehlich, Andreas
In mouse mutants incapable of expressing μ chains, VκJκ joints are detected in the CD43+ B cell progenitors. In agreement with these earlier results, we show by a molecular single cell analysis...
Arhgef1 Is Required by T Cells for the Development of Airway Hyperreactivity and Inflammation
Brown, Jeanette P., Taube, Christian, Miyahara, Nobuaki, Koya, Toshiyuki, Pelanda, Roberta, Gelfand, Erwin W., ...
Rationale: Arhgef1 is an intracellular protein, expressed by hematopoietic cells, that regulates signaling by both G protein–coupled receptors and RhoA, and, consequently, is required for...