Roberto F. Machado

Erythrocytes are the major intravascular storage sites of nitrite in human blood

Dejam, André, Hunter, Christian J., Pelletier, Mildred M., Hsu, Lewis L., Machado, Roberto F., Shiva, Sruti, ...

Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Recent data suggest that nitrite is a potential intravascular repository for nitric oxide...

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Kato, Gregory J., McGowan, Vicki, Machado, Roberto F., Little, Jane A., Taylor, James, Morris, Claudia R., ...

Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly associated with early mortality and markers of hemolysis, in particular, serum lactate dehydrogenase...

Sildenafil in the treatment of pulmonary hypertension

Barnett, Christopher F, Machado, Roberto F

The therapy of pulmonary hypertension has evolved rapidly in the last 10 years from the use of non-selective vasodilators to drugs that specifically target pulmonary vasodilation, endothelial...

Hemodynamic and Functional Assessment of Patients with Sickle Cell Disease and Pulmonary Hypertension

Anthi, Anastasia, Machado, Roberto F., Jison, Maria L., Taveira-DaSilva, Angelo M., Rubin, Lewis J., Hunter, Lori, ...

Rationale: Although pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) associated with high mortality, there exist few data characterizing hemodynamics and...

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

Villagra, José, Shiva, Sruti, Hunter, Lori A., Machado, Roberto F., Gladwin, Mark T., Kato, Gregory J.

Increased platelet activation is recognized in patients with sickle cell disease (SCD), but its pathogenesis and clinical relevance remain uncertain. Pulmonary arterial hypertension (PAH), an...

Detection of Lung Cancer by Sensor Array Analyses of Exhaled Breath

Machado, Roberto F., Laskowski, Daniel, Deffenderfer, Olivia, Burch, Timothy, Zheng, Shuo, Mazzone, Peter J., ...

Rationale: Electronic noses are successfully used in commercial applications, including detection and analysis of volatile organic compounds in the food industry. Objectives: We hypothesized that the...