Roberto Romero

A Regularized Regression Approach for Dissecting Genetic Conflicts that Increase Disease Risk in Pregnancy (2009)

Li, Shaoyu, Lu, Qing, Fu, Wenjiang, Romero, Roberto, Cui, Yuehua

Human diseases developed during pregnancy could be caused by the direct effects of both maternal and fetal genes, and/or by the indirect effects caused by genetic conflicts. Genetic conflicts exist...

A Regularized Regression Approach for Dissecting Genetic Conflicts that Increase Disease Risk in Pregnancy (2009)

Li, Shaoyu, Lu, Qing, Fu, Wenjiang, Romero, Roberto, Cui, Yuehua

Human diseases developed during pregnancy could be caused by the direct effects of both maternal and fetal genes, and/or by the indirect effects caused by genetic conflicts. Genetic conflicts exist...

A Regularized Regression Approach for Dissecting Genetic Conflicts that Increase Disease Risk in Pregnancy (2009)

Li, Shaoyu, Lu, Qing, Fu, Wenjiang, Romero, Roberto, Cui, Yuehua

Human diseases developed during pregnancy could be caused by the direct effects of both maternal and fetal genes, and/or by the indirect effects caused by genetic conflicts. Genetic conflicts exist...

A Regularized Regression Approach for Dissecting Genetic Conflicts that Increase Disease Risk in Pregnancy (2009)

Li, Shaoyu, Lu, Qing, Fu, Wenjiang, Romero, Roberto, Cui, Yuehua

Human diseases developed during pregnancy could be caused by the direct effects of both maternal and fetal genes, and/or by the indirect effects caused by genetic conflicts. Genetic conflicts exist...

Failure of E. colibacteria to induce preterm delivery in the rat (2009)

Hirsch, Emmet, Filipovich, Yana, Romero, Roberto

Abstract Background We sought to develop a model of bacterially induced preterm delivery in rats to parallel similar models in mice. Methods Female Sprague-Dawley rats on day 17 of gestation (normal...

A novel signaling pathway impact analysis (2009)

Tarca, Adi Laurentiu, Draghici, Sorin, Khatri, Purvesh, Hassan, Sonia S., Mittal, Pooja, Kim, Jung-sun, ...

Motivation: Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result of...

Retrieval of trophoblast cells from the cervical canal for prediction of abnormal pregnancy: a pilot study (2009)

Imudia, Anthony N., Suzuki, Yoko, Kilburn, Brian A., Yelian, Frank D., Diamond, Michael P., Romero, Roberto, ...

BACKGROUND Fetal cells are shed from the regressing chorionic villi and it is possible to retrieve extravillous cytotrophoblast cells by transcervical sampling. The abundance of trophoblast cells in...

Visfatin in human pregnancy (2008)

Mazaki-Tovi, Shali, Romero, Roberto, Kusanovic, Juan Pedro, Vaisbuch, Edi, Erez, Offer, Than, Nandor Gabor, ...

Objective: Adipose tissue dysfunction, characterized by dysregulation of adipokines production and/or secretion, has been implicated in the pathophysiology of type-2 diabetes mellitus, a metabolic...

Visfatin in human pregnancy (2008)

Mazaki-Tovi, Shali, Romero, Roberto, Kusanovic, Juan Pedro, Vaisbuch, Edi, Erez, Offer, Than, Nandor Gabor, ...

Objective: Adipose tissue dysfunction, characterized by dysregulation of adipokines production and/or secretion, has been implicated in the pathophysiology of type-2 diabetes mellitus, a metabolic...

Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia (2008)

Parimi, Neeta, Tromp, Gerard, Kuivaniemi, Helena, Nien, Jyh, Gomez, Ricardo, Romero, Roberto, ...

Abstract Background In utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia...

A System Biology Approach for the Steady-State Analysis of Gene Signaling Networks (2008)

Purvesh Khatri, Sorin Draghici, Adil. Tarca, Sonia S. Hassan, Roberto Romero

Abstract. The existing approaches used to identify the relevant pathways in a given condition do not consider a number of important biological factors such as magnitude of each gene’s expression...

Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia. (2008)

Parimi, Neeta, Tromp, Gerard, Kuivaniemi, Helena, Nien, Jyh Kae, Gomez, Ricardo, Romero, Roberto, ...

BACKGROUND: In utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia (PE)....

Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes (2008)

Wang, Hongyan, Ogawa, Masaki, Wood, Jennifer R., Bartolomei, Marisa S., Sammel, Mary D., Kusanovic, Juan Pedro, ...

Degradation of fibrillar collagens is believed to be involved in the rupture of the fetal membranes during normal parturition and when the membranes rupture prematurely. Matrix metalloproteinase 1...

One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency (2008)

Furness, Denise Lyndal Fleur, Fenech, Michael F., Khong, Teck Yee, Romero, Roberto, Dekker, Gustaaf Albert

Presented at the 28th Annual Meeting of the Society for Maternal–Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.

One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency (2008)

Furness, Denise Lyndal Fleur, Fenech, Michael F., Khong, Teck Yee, Romero, Roberto, Dekker, Gustaaf Albert

Presented at the 28th Annual Meeting of the Society for Maternal–Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.

A systems biology approach for pathway level analysis (2007)

Draghici, Sorin, Khatri, Purvesh, Tarca, Adi Laurentiu, Amin, Kashyap, Done, Arina, Voichita, Calin, ...

A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions taking place on various signaling pathways. A...

OCPAT: an online codon-preserved alignment tool for evolutionary genomic analysis of protein coding sequences (2007)

Liu, Guozhen, Uddin, Monica, Islam, Munirul, Goodman, Morris, Grossman, Lawrence I, Romero, Roberto, ...

Abstract Background Rapidly accumulating genome sequence data from multiple species offer powerful opportunities for the detection of DNA sequence evolution. Phylogenetic tree construction and...

The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes (2007)

Friel, Lara A., Romero, Roberto, Edwin, Sam, Nien, Jyh Kae, Gomez, Ricardo, Chaiworapongsa, Tinnakorn, ...

Objective: S100B is produced by glia of the central and peripheral nervous systems and is considered a marker of neurologic injury in the perinatal period. Indeed, increased neonatal urine S100B...

The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes (2007)

Friel, Lara A., Romero, Roberto, Edwin, Sam, Nien, Jyh Kae, Gomez, Ricardo, Chaiworapongsa, Tinnakorn, ...

Objective: S100B is produced by glia of the central and peripheral nervous systems and is considered a marker of neurologic injury in the perinatal period. Indeed, increased neonatal urine S100B...

Genomics, biogeography, and the diversification of placental mammals (2007)

E. Wildman, Derek, Uddin, Monica, C. Opazo, Juan, Liu, Guozhen, Lefort, Vincent, Guindon, Stephane, ...

Previous molecular analyses of mammalian evolutionary relationships involving a wide range of placental mammalian taxa have been restricted in size from one to two dozen gene loci and have not...

Genomics, biogeography, and the diversification of placental mammals (2007)

E. Wildman, Derek, Uddin, Monica, C. Opazo, Juan, Liu, Guozhen, Lefort, Vincent, Guindon, Stephane, ...

Previous molecular analyses of mammalian evolutionary relationships involving a wide range of placental mammalian taxa have been restricted in size from one to two dozen gene loci and have not...

A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans (2006)

Wang, Hongyan, Parry, Samuel, Macones, George, Sammel, Mary D., Kuivaniemi, Helena, Tromp, Gerard, ...

Prematurity is more prevalent in African Americans than in European Americans. We investigated the contribution of a functional SNP in the promoter of the SERPINH1 gene, enriched among those of...

Antibiotic administration to patients with preterm labor and intact membranes: Is there a beneficial effect in patients with endocervical inflammation? (2006)

Ovalle, Alfredo, Romero, Roberto, Gómez, Ricardo, Martínez, M. Angélica, Nien, Jyh Kae, Ferrand, Pedro, ...

Objective. To determine whether broad-spectrum antibiotic administration to patients with preterm labor and intact membranes is associated with an improvement in neonatal and maternal outcomes,...

Insights into the Physiology of Childbirth Using Transcriptomics (2006)

Roberto Romero, Adi L. Tarca, Gerard Tromp

Romero and colleagues discuss a study in PLoS Medicine that used microarrays to determine labor-associated gene expression profiles in the human uterus.

Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy (2006)

Kindzelskii, Andrei L., Clark, Andrea J., Espinoza, Jimmy, Maeda, Nobuyo, Aratani, Yasuaki, Romero, Roberto

Pregnancy is a unique immunological state. Pregnancy neutrophils differ from those of non-pregnant women as they cannot be fully activated for oxidant production, but yet have higher levels of...

Identification of novel functional sequence variants in the gene for peptidase inhibitor 3 (2006)

Chowdhury, Mahboob A, Kuivaniemi, Helena, Romero, Roberto, Edwin, Samuel, Chaiworapongsa, Tinnakorn, Tromp, Gerard

Abstract Background Peptidase inhibitor 3 (PI3) inhibits neutrophil elastase and proteinase-3, and has a potential role in skin and lung diseases as well as in cancer. Genome-wide expression...

New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate (2006)

Khatri, Purvesh, Desai, Valmik, Tarca, Adi L., Sellamuthu, Sivakumar, Wildman, Derek E., Romero, Roberto, ...

The Onto-Tools suite is composed of an annotation database and eight complementary, web-accessible data mining tools: Onto-Express, Onto-Compare, Onto-Design, Onto-Translate, Onto-Miner,...

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C) (2006)

Abrahams, Vikki M., Schaefer, Todd M., Fahey, John V., Visintin, Irene, Wright, Jacqueline A., Aldo, Paulomi B., ...

BACKGROUND: During pregnancy, the placenta may become exposed to micro-organisms, such as viruses, which may pose a substantial threat to the embryo/fetus well-being. Recent insight into the...

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C) (2006)

Abrahams, Vikki M., Schaefer, Todd M., Fahey, John V., Visintin, Irene, Wright, Jacqueline A., Aldo, Paulomi B., ...

BACKGROUND: During pregnancy, the placenta may become exposed to micro-organisms, such as viruses, which may pose a substantial threat to the embryo/fetus well-being. Recent insight into the...

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C) (2006)

Abrahams, Vikki M., Schaefer, Todd M., Fahey, John V., Visintin, Irene, Wright, Jacqueline A., Aldo, Paulomi B., ...

BACKGROUND: During pregnancy, the placenta may become exposed to micro-organisms, such as viruses, which may pose a substantial threat to the embryo/fetus well-being. Recent insight into the...

The exact solution of the Riemann problem in relativistic MHD with tangential magnetic fields (2005)

Romero, Roberto, Marti, Jose M., Pons, Jose A., Ibanez, Jose M., Miralles, Juan A.

We have extended the procedure to find the exact solution of the Riemann problem in relativistic hydrodynamics to a particular case of relativistic magnetohydrodynamics in which the magnetic field of...

Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM) (2004)

Wang, Hongyan, Parry, Samuel, Macones, George, Sammel, Mary D., Ferrand, Pedro E., Kuivaniemi, Helena, ...

Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. We identified...

Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM) (2004)

Wang, Hongyan, Parry, Samuel, Macones, George, Sammel, Mary D., Ferrand, Pedro E., Kuivaniemi, Helena, ...

Matrix metalloproteinase 8 (MMP8), an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. We identified...

E4 Thematic Network: Enhancing engineering Education in Europe - Volume E: Part I: Activity 3: Engineering professional development for Europe; Part II: Activity 4: Enhancing the European dimension (2003)

Montesinos, Patricio, Romero, Roberto, Charlot, Jean-Pierre, Chisleag, Radu, Mulhall, Brian

This Thematic Network aims at developing the European dimension of Higher Engineering Education by enhancing the compatibility of the many diverse routes to the profession of engineer, by...

Nasal bone evaluation in fetuses with Down syndrome during the second and third trimesters of pregnancy (2003)

Lee, Wesley, DeVore, Greggory R., Comstock, Christine H., Kalache, Karim D., McNie, Beverley, Chaiworapongsa, Tinnakorn, ...

Objective: this study examined the use of three-dimensional ultrasonography for evaluating the fetal nasal bone, as a sonographic marker of Down syndrome, during the second and early third trimesters...

Three-dimensional power Doppler ultrasonography during pregnancy (2003)

Lee, Wesley, Kalache, Karim D., Chaiworapongsa, Tinnakorn, Londono, Jorge, Treadwell, Marjorie C., Johnson, Anthony, ...

Objectives: to present the appearance of fetal and placental vascular anatomic structures by three-dimensional power Doppler ultrasonography. Methods: three-dimensional multiplanar imaging, surface...

Prenatal diagnosis of dilated coronary sinus with persistent left superior vena cava in a fetus with trisomy 18 (2003)

Kalache, Karim D., Romero, Roberto, Conoscenti, Giancarlo, Qureshi, Faisal, Jacques, Suzanne M., Chaiworapongsa, Tinnakorn, ...

A case of dilated coronary sinus with persistent left superior vena cava diagnosed at 33 weeks in a fetus with trisomy 18 is reported. The features of this cardiac anomaly on prenatal ultrasonography...

Three-dimensional color power imaging of the fetal hepatic circulation (2003)

Kalache, Karim, Romero, Roberto, Goncalves, Luis F., Chaiworapongsa, Tinnakorn, Espinoza, Jimmy, Schoen, Mary Lou, ...

Objective The purpose of this study was to describe the use of three-dimensional power Doppler ultrasonography to identify vascular congenital anomalies of fetal portosystemic and umbilical venous...

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes (2003)

Keelan, Jeffrey A., Wang, Kaye, Chaiworapongsa, Tinnakorn, Romero, Roberto, Mitchell, Murray D., Sato, Timothy A., ...

The placenta and fetal membranes are the site of expression of macrophage inhibitory cytokine (MIC‐1), a member of the transforming growth factor (TGF)‐β superfamily. We hypothesized that...

Three-dimensional ultrasonographic presentation of micrognathia (2002)

Lee, Wesley, McNie, Beverley, Chaiworapongsa, Tinnakorn, Conoscenti, Giancarlo, Kalache, Karim D., Vettraino, Ivana M., ...

Objective: to present the variable appearance of micrognathia in fetuses by three-dimensional ultrasonography and to describe practical methods for analysis of these volume data. Methods:...

Infection and prematurity and the role of preventive strategies (2002)

Romero, Roberto, Espinoza, Jimmy, Chaiworapongsa, Tinnakorn, Kalache, Karim

This article reviews the role of infection in spontaneous premature parturition, the pathways of ascending intrauterine infection, microbiology, and the frequency of intra-amniotic infection in...

The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM) (2002)

Ferrand, Pedro E., Fujimoto, Toshio, Chennathukuzhi, Vargheese, Parry, Samuel, Macones, George A., Sammel, Mary, ...

Infection is believed to be a leading cause of preterm premature rupture of membranes (PPROM). The bacterial cell wall component, lipopolysaccharide (LPS), is thought to initiate tissue responses...

A polymorphism in the matrix metalloproteinase-9 promoter is associated with increased risk of preterm premature rupture of membranes in African Americans (2002)

Ferrand, Pedro E., Parry, Samuel, Sammel, Mary, Macones, George A., Kuivaniemi, Helena, Romero, Roberto, ...

Fetal membrane rupture is associated with increased expression of matrix metalloproteinase-9 (MMP-9) and matrix degradation. We have determined the functional significance of a variable number tandem...

Prenatal diagnosis of nonrhizomelic chondrodysplasiapunctata (Conradi-HÜnermann syndrome) (1993)

Pryde, Peter G., Bawle, Erawati V., Brandt, Francisco, Romero, Roberto, Treadwell, Marjorie C., Evans, Mark I.

Chondrodysplasia punctata has been classified into two major types including the rare autosomal recessive “rhizomelic type” and a more common but genetically heterogenous nonrhizomelic type...

Physiology: Electromechanical activities of human uteri during extra-corporeal perfusion with ovarian steroids (1993)

Bulletti, Carlo, Prefetto, Rosa Anna, Bazzocchi, Gabriele, Romero, Roberto, Mimmi, Patrizia, Polli, Valeria, ...

A new experimental system was designed to study human uterine activities based on the extra-corporeal perfusion of isolated human uteri. Electromechanical activities in the uterine wall were recorded...

Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils

Kindzelskii, Andrei L., Huang, Ji-Biao, Chaiworapongsa, Tinnakorn, Fahmy, Ryan M., Kim, Yeon Mee, Romero, Roberto, ...

Pregnancy is associated with changes in host susceptibility to infections and inflammatory disease. We hypothesize that metabolic enzyme trafficking affects maternal neutrophil activation....

NORMAL PREGNANCY IS CHARACTERIZED BY SYSTEMIC ACTIVATION OF THE COMPLEMENT SYSTEM

RICHANI, KARINA, SOTO, ELEAZAR, ROMERO, ROBERTO, ESPINOZA, JIMMY, CHAIWORAPONGSA, TINNAKORN, NIEN, JYH KAE, ...

BACKGROUND: The complement system, a major component of innate immunity, has recently been implicated in the mechanisms of fetal loss and placental inflammation in the anti-phospholipid antibody...

Insights into the Physiology of Childbirth Using Transcriptomics

Romero, Roberto, Tarca, Adi L, Tromp, Gerard

Romero and colleagues discuss a study in PLoS Medicine that used microarrays to determine labor-associated gene expression profiles in the human uterus.

Evolution of the mammalian placenta revealed by phylogenetic analysis

Wildman, Derek E., Chen, Caoyi, Erez, Offer, Grossman, Lawrence I., Goodman, Morris, Romero, Roberto

The placenta is essential for the success of therian mammalian reproduction. Intense selective pressure has shaped changes in placental anatomy and function during mammalian cladogenesis. Here we...

New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate

Khatri, Purvesh, Desai, Valmik, Tarca, Adi L., Sellamuthu, Sivakumar, Wildman, Derek E., Romero, Roberto, ...

The Onto-Tools suite is composed of an annotation database and eight complementary, web-accessible data mining tools: Onto-Express, Onto-Compare, Onto-Design, Onto-Translate, Onto-Miner,...

Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils

Kindzelskii, Andrei L., Huang, Ji-Biao, Chaiworapongsa, Tinnakorn, Fahmy, Ryan M., Kim, Yeon Mee, Romero, Roberto, ...

Pregnancy is associated with changes in host susceptibility to infections and inflammatory disease. We hypothesize that metabolic enzyme trafficking affects maternal neutrophil activation....

Evolution of the mammalian placenta revealed by phylogenetic analysis

Wildman, Derek E., Chen, Caoyi, Erez, Offer, Grossman, Lawrence I., Goodman, Morris, Romero, Roberto

The placenta is essential for the success of therian mammalian reproduction. Intense selective pressure has shaped changes in placental anatomy and function during mammalian cladogenesis. Here we...

Insights into the Physiology of Childbirth Using Transcriptomics

Romero, Roberto, Tarca, Adi L, Tromp, Gerard

Romero and colleagues discuss a study in PLoS Medicine that used microarrays to determine labor-associated gene expression profiles in the human uterus.

New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate

Khatri, Purvesh, Desai, Valmik, Tarca, Adi L., Sellamuthu, Sivakumar, Wildman, Derek E., Romero, Roberto, ...

The Onto-Tools suite is composed of an annotation database and eight complementary, web-accessible data mining tools: Onto-Express, Onto-Compare, Onto-Design, Onto-Translate, Onto-Miner,...

A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans

Wang, Hongyan, Parry, Samuel, Macones, George, Sammel, Mary D., Kuivaniemi, Helena, Tromp, Gerard, ...

Prematurity is more prevalent in African Americans than in European Americans. We investigated the contribution of a functional SNP in the promoter of the SERPINH1 gene, enriched among those of...

Genomics, biogeography, and the diversification of placental mammals

Wildman, Derek E., Uddin, Monica, Opazo, Juan C., Liu, Guozhen, Lefort, Vincent, Guindon, Stephane, ...

Previous molecular analyses of mammalian evolutionary relationships involving a wide range of placental mammalian taxa have been restricted in size from one to two dozen gene loci and have not...

A systems biology approach for pathway level analysis

Draghici, Sorin, Khatri, Purvesh, Tarca, Adi Laurentiu, Amin, Kashyap, Done, Arina, Voichita, Calin, ...

A common challenge in the analysis of genomics data is trying to understand the underlying phenomenon in the context of all complex interactions taking place on various signaling pathways. A...

Gene-Centric Genomewide Association Study via Entropy

Cui, Yuehua, Kang, Guolian, Sun, Kelian, Qian, Minping, Romero, Roberto, Fu, Wenjiang

Genes are the functional units in most organisms. Compared to genetic variants located outside genes, genic variants are more likely to affect disease risk. The development of the human HapMap...

Distinct genomic signatures of adaptation in pre- and postnatal environments during human evolution

Uddin, Monica, Goodman, Morris, Erez, Offer, Romero, Roberto, Liu, Guozhen, Islam, Munirul, ...

The human genome evolution project seeks to reveal the genetic underpinnings of key phenotypic features that are distinctive of humans, such as a greatly enlarged cerebral cortex, slow development,...

Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal–fetal immune tolerance

Than, Nandor Gabor, Romero, Roberto, Erez, Offer, Weckle, Amy, Tarca, Adi L., Hotra, John, ...

Galectin-1 is an anti-inflammatory lectin with pleiotropic regulatory functions at the crossroads of innate and adaptive immunity. It is expressed in immune privileged sites and is implicated in...

Mapping Nucleotide Sequences that Encode Complex Binary Disease Traits with HapMap

Cui, Yuehua, Fu, Wenjiang, Sun, Kelian, Romero, Roberto, Wu, Rongling

Detecting the patterns of DNA sequence variants across the human genome is a crucial step for unraveling the genetic basis of complex human diseases. The human HapMap constructed by single nucleotide...

A primate subfamily of galectins expressed at the maternal–fetal interface that promote immune cell death

Than, Nandor Gabor, Romero, Roberto, Goodman, Morris, Weckle, Amy, Xing, Jun, Dong, Zhong, ...

Galectins are proteins that regulate immune responses through the recognition of cell-surface glycans. We present evidence that 16 human galectin genes are expressed at the maternal–fetal interface...

Ancient origin of placental expression in the growth hormone genes of anthropoid primates

Papper, Zack, Jameson, Natalie M., Romero, Roberto, Weckle, Amy L., Mittal, Pooja, Benirschke, Kurt, ...

In anthropoid primates, growth hormone (GH) genes have undergone at least 2 independent locus expansions, one in platyrrhines (New World monkeys) and another in catarrhines (Old World monkeys and...