Robin G. Lorenz

Epithelial attachment alters the outcome of Helicobacter pylori infection

Guruge, Janaki L., Falk, Per G., Lorenz, Robin G., Dans, Maria, Wirth, Hans-Peter, Blaser, Martin J., ...

Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common...

A role for IL-1α in inducing pathologic inflammation during bacterial infection

Dube, Peter H., Revell, Paula A., Chaplin, David D., Lorenz, Robin G., Miller, Virginia L.

Infection with pathogenic microbes often results in a significant inflammatory response. A cascade of proinflammatory cytokines including tumor necrosis factor α (TNF-α) and IL-1 initiates this...

Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli

Schilling, Joel D., Lorenz, Robin G., Hultgren, Scott J.

One of the more perplexing aspects of urinary tract infections (UTIs) is their high propensity to recur. It has been proposed that recurrent infections are a result of the reintroduction of bacteria...

CD14- and Toll-Like Receptor-Dependent Activation of Bladder Epithelial Cells by Lipopolysaccharide and Type 1 Piliated Escherichia coli

Schilling, Joel D., Martin, Steven M., Hunstad, David A., Patel, Kunal P., Mulvey, Matthew A., Justice, Sheryl S., ...

The gram-negative bacterium Escherichia coli is the leading cause of urinary tract infection. The interaction between type 1 piliated E. coli and bladder epithelial cells leads to the rapid...

Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli

Schilling, Joel D., Martin, Steven M., Hung, Chia S., Lorenz, Robin G., Hultgren, Scott J.

Innate host defenses at mucosal surfaces are critical in the early stages of many bacterial infections. In addition to cells of the traditional innate immune system, epithelial cells can also produce...

Epithelial attachment alters the outcome of Helicobacter pylori infection

Guruge, Janaki L., Falk, Per G., Lorenz, Robin G., Dans, Maria, Wirth, Hans-Peter, Blaser, Martin J., ...

Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common...

A role for IL-1α in inducing pathologic inflammation during bacterial infection

Dube, Peter H., Revell, Paula A., Chaplin, David D., Lorenz, Robin G., Miller, Virginia L.

Infection with pathogenic microbes often results in a significant inflammatory response. A cascade of proinflammatory cytokines including tumor necrosis factor α (TNF-α) and IL-1 initiates this...

Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli

Schilling, Joel D., Lorenz, Robin G., Hultgren, Scott J.

One of the more perplexing aspects of urinary tract infections (UTIs) is their high propensity to recur. It has been proposed that recurrent infections are a result of the reintroduction of bacteria...

CD14- and Toll-Like Receptor-Dependent Activation of Bladder Epithelial Cells by Lipopolysaccharide and Type 1 Piliated Escherichia coli

Schilling, Joel D., Martin, Steven M., Hunstad, David A., Patel, Kunal P., Mulvey, Matthew A., Justice, Sheryl S., ...

The gram-negative bacterium Escherichia coli is the leading cause of urinary tract infection. The interaction between type 1 piliated E. coli and bladder epithelial cells leads to the rapid...

Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli

Schilling, Joel D., Martin, Steven M., Hung, Chia S., Lorenz, Robin G., Hultgren, Scott J.

Innate host defenses at mucosal surfaces are critical in the early stages of many bacterial infections. In addition to cells of the traditional innate immune system, epithelial cells can also produce...