Rodney Arthur Lea

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma. (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma. (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue (2006)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Previous studies in our laboratory have shown association of nuclear receptor expression and histological breast cancer grade. To further investigate these findings, it was the objective of this...

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Use of the Norfolk Island Genetic Isolate to Identify Genetic Risk Factors for CVD. (2005)

Griffiths, Lyn, Bellis, Claire, Lea, Rodney Arthur, Hughes, Roger Michael, Quinlan, Sharon Anne, Heath, S., ...

Geographical isolation and limited environmental variation make genetic isolates powerful tools for gene mapping. Our research is aimed at identifying the genes that play a role in cardiovascular...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independant case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillian, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine.Background. Migraine is a chronic debilitating disorder affecting approximately...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...