Curtis, Christina, Landis, Gary N, Folk, Donna, Wehr, Nancy B, Hoe, Nicholas, Waskar, Morris, ...
Abstract Background Several interventions increase lifespan in model organisms, including reduced insulin/insulin-like growth factor-like signaling (IIS), FOXO transcription factor activation,...
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. (1999)
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia-telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Requena, Jesús R., Chao, Chien-Chung, Levine, Rodney L., Stadtman, Earl R.
Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl...
Antioxidant activity of Ferrozine–iron–amino acid complexes
Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Chevion, Mordechai, Stadtman, Earl R.
Amino acid–Fe(II)–chelator complexes exhibit strong antioxidant activity. Taking advantage of the unique spectral characteristics of the complexes formed when Ferrozine (Fz) is used as the...
Lee, Seung-Rock, Bar-Noy, Shoshana, Kwon, Jaeyul, Levine, Rodney L., Stadtman, Thressa C., Rhee, Sue Goo
Mammalian cytosolic thioredoxin reductase (TrxR) has a redox center, consisting of Cys59/Cys64 adjacent to the flavin ring of FAD and another center consisting of Cys497/selenocysteine (SeCys)498...
Berlett, Barbara S., Levine, Rodney L., Stadtman, Earl R.
The activity of glutamine synthetase (EC 6.3.1.2) from Escherichia coli is regulated by the cyclic adenylylation and deadenylylation of Tyr-397 in each of the enzyme’s 12 identical subunits. The...
Iwai, Kazuhiro, Drake, Steven K., Wehr, Nancy B., Weissman, Allan M., LaVaute, Timothy, Minato, Nagahiro, ...
The ability of iron to catalyze formation of reactive oxygen species significantly contributes to its toxicity in cells and animals. Iron uptake and distribution is regulated tightly in mammalian...
Tien, Ming, Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Stadtman, Earl R.
The ability of peroxynitrite to modify amino acid residues in glutamine synthetase (GS) and BSA is greatly influenced by pH and CO2. At physiological concentrations of CO2 (1.3 mM), the generation of...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Oxidative damage during aging targets mitochondrial aconitase
Yan, Liang-Jun, Levine, Rodney L., Sohal, Rajindar S.
The mechanisms that cause aging are not well understood. The oxidative stress hypothesis proposes that the changes associated with aging are a consequence of random oxidative damage to biomolecules....
Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein
Requena, Jesús R., Groth, Darlene, Legname, Giuseppe, Stadtman, Earl R., Prusiner, Stanley B., Levine, Rodney L.
Metal-catalyzed oxidation may result in structural damage to proteins and has been implicated in aging and disease, including neurological disorders such as Alzheimer's disease and amyotrophic...
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...
In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...
Lacourciere, Gerard M., Levine, Rodney L., Stadtman, Thressa C.
Selenium can be metabolized for protein synthesis by two major pathways in vivo. In a specific pathway it can be inserted into polypeptide chains as the amino acid selenocysteine, as directed by the...
Group B streptococcal phospholipid causes pulmonary hypertension
Curtis, Jerri, Kim, Geumsoo, Wehr, Nancy B., Levine, Rodney L.
Group B Streptococcus is the most common cause of bacterial infection in the newborn. Infection in many cases causes persistent pulmonary hypertension, which impairs gas exchange in the lung. We...
Zhang, Zheng, Dmitrieva, Natalia I., Park, Jong-Hwan, Levine, Rodney L., Burg, Maurice B.
Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in...
Carbonic Anhydrase III Is Not Required in the Mouse for Normal Growth, Development, and Life Span
Kim, Geumsoo, Lee, Tae-Hoon, Wetzel, Petra, Geers, Cornelia, Robinson, Mary Ann, Myers, Timothy G., ...
Carbonic anhydrase III is a cytosolic protein which is particularly abundant in skeletal muscle, adipocytes, and liver. The specific activity of this isozyme is quite low, suggesting that its...
Zhao, Hongtao, Joseph, Joy, Fales, Henry M., Sokoloski, Edward A., Levine, Rodney L., Vasquez-Vivar, Jeannette, ...
Here we report the structural characterization of the product formed from the reaction between hydroethidine (HE) and superoxide (\documentclass[12pt]{minimal} \usepackage{amsmath}...
Requena, Jesús R., Chao, Chien-Chung, Levine, Rodney L., Stadtman, Earl R.
Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl...
Antioxidant activity of Ferrozine–iron–amino acid complexes
Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Chevion, Mordechai, Stadtman, Earl R.
Amino acid–Fe(II)–chelator complexes exhibit strong antioxidant activity. Taking advantage of the unique spectral characteristics of the complexes formed when Ferrozine (Fz) is used as the...
Lee, Seung-Rock, Bar-Noy, Shoshana, Kwon, Jaeyul, Levine, Rodney L., Stadtman, Thressa C., Rhee, Sue Goo
Mammalian cytosolic thioredoxin reductase (TrxR) has a redox center, consisting of Cys59/Cys64 adjacent to the flavin ring of FAD and another center consisting of Cys497/selenocysteine (SeCys)498...
Berlett, Barbara S., Levine, Rodney L., Stadtman, Earl R.
The activity of glutamine synthetase (EC 6.3.1.2) from Escherichia coli is regulated by the cyclic adenylylation and deadenylylation of Tyr-397 in each of the enzyme’s 12 identical subunits. The...
Iwai, Kazuhiro, Drake, Steven K., Wehr, Nancy B., Weissman, Allan M., LaVaute, Timothy, Minato, Nagahiro, ...
The ability of iron to catalyze formation of reactive oxygen species significantly contributes to its toxicity in cells and animals. Iron uptake and distribution is regulated tightly in mammalian...
Tien, Ming, Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Stadtman, Earl R.
The ability of peroxynitrite to modify amino acid residues in glutamine synthetase (GS) and BSA is greatly influenced by pH and CO2. At physiological concentrations of CO2 (1.3 mM), the generation of...
Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs
Barlow, Carrolee, Dennery, Phyllis A., Shigenaga, Mark K., Smith, Mark A., Morrow, Jason D., Roberts, L. Jackson, ...
Ataxia–telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje...
Oxidative damage during aging targets mitochondrial aconitase
Yan, Liang-Jun, Levine, Rodney L., Sohal, Rajindar S.
The mechanisms that cause aging are not well understood. The oxidative stress hypothesis proposes that the changes associated with aging are a consequence of random oxidative damage to biomolecules....
Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein
Requena, Jesús R., Groth, Darlene, Legname, Giuseppe, Stadtman, Earl R., Prusiner, Stanley B., Levine, Rodney L.
Metal-catalyzed oxidation may result in structural damage to proteins and has been implicated in aging and disease, including neurological disorders such as Alzheimer's disease and amyotrophic...
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...
In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...
Lacourciere, Gerard M., Levine, Rodney L., Stadtman, Thressa C.
Selenium can be metabolized for protein synthesis by two major pathways in vivo. In a specific pathway it can be inserted into polypeptide chains as the amino acid selenocysteine, as directed by the...
Group B streptococcal phospholipid causes pulmonary hypertension
Curtis, Jerri, Kim, Geumsoo, Wehr, Nancy B., Levine, Rodney L.
Group B Streptococcus is the most common cause of bacterial infection in the newborn. Infection in many cases causes persistent pulmonary hypertension, which impairs gas exchange in the lung. We...
Zhang, Zheng, Dmitrieva, Natalia I., Park, Jong-Hwan, Levine, Rodney L., Burg, Maurice B.
Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in...
Carbonic Anhydrase III Is Not Required in the Mouse for Normal Growth, Development, and Life Span
Kim, Geumsoo, Lee, Tae-Hoon, Wetzel, Petra, Geers, Cornelia, Robinson, Mary Ann, Myers, Timothy G., ...
Carbonic anhydrase III is a cytosolic protein which is particularly abundant in skeletal muscle, adipocytes, and liver. The specific activity of this isozyme is quite low, suggesting that its...
Zhao, Hongtao, Joseph, Joy, Fales, Henry M., Sokoloski, Edward A., Levine, Rodney L., Vasquez-Vivar, Jeannette, ...
Here we report the structural characterization of the product formed from the reaction between hydroethidine (HE) and superoxide (\documentclass[12pt]{minimal} \usepackage{amsmath}...
Liu, Xiong, Shu, Shi, Hong, Myoung-Soon S., Levine, Rodney L., Korn, Edward D.
Dictyostelium actin was shown to become phosphorylated on Tyr-53 late in the developmental cycle and when cells in the amoeboid stage are subjected to stress but the phosphorylated actin had not been...
Curtis, Christina, Landis, Gary N, Folk, Donna, Wehr, Nancy B, Hoe, Nicholas, Waskar, Morris, ...
Transcriptional profiling of MnSOD-mediated life-span extension in Drosophila identifies a set of candidate biomarkers of aging, consisting primarily of carbohydrate metabolism and electron transport...
Chen, Weisan, Yewdell, Jonathan W., Levine, Rodney L., Bennink, Jack R.
In studying the subdominant status of two cysteine-containing influenza virus nuclear protein (NP) determinants (NP39–47 and NP218–226) restricted by H-2Kd, we found that the antigenicity of...
Guyot, Nicolas, Butler, Marcus W., McNally, Paul, Weldon, Sinead, Greene, Catherine M., Levine, Rodney L., ...
Elafin is a neutrophil serine protease inhibitor expressed in lung and displaying anti-inflammatory and anti-bacterial properties. Previous studies demonstrated that some innate host defense...